• Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor 

      Valle Turrillas, Jaione Upna; Latasa Osta, Cristina Upna; Gil Puig, Carmen Upna; Toledo Arana, Alejandro Upna; Solano Goñi, Cristina Upna; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (Public Library of Science, 2012)   Artículo / Artikulua  OpenAccess
      The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ...
    • Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection 

      Gil Puig, Carmen Upna; Solano Goñi, Cristina Upna; Burgui Erice, Saioa Upna; Latasa Osta, Cristina Upna; García Martínez, Begoña Upna; Toledo Arana, Alejandro Upna; Lasa Uzcudun, Íñigo Upna; Valle Turrillas, Jaione Upna (American Society for Microbiology, 2014)   Artículo / Artikulua  OpenAccess
      The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ...
    • Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate 

      Pérez, Astrid; Canle, D.; Latasa Osta, Cristina Upna; Poza, M.; Beceiro, A.; Tomás, María del Mar; Fernandez, A.; Mallo, S.; Perez, S.; Molina, F.; Villanueva, R.; Lasa Uzcudun, Íñigo Upna; Bou, Germán (American Society for Microbiology, 2007)   Artículo / Artikulua  OpenAccess
      Enterobacter cloacae is an emerging clinical pathogen that may be responsible for nosocomial infections. Management of these infections is often difficult, owing to the high frequency of strains that are resistant to ...
    • Coordinated cyclic-di-GMP repression of salmonella motility through YcgR and cellulose 

      Zorraquino Salvo, Violeta; García Martínez, Begoña Upna; Latasa Osta, Cristina Upna; Echeverz Sarasúa, Maite Upna; Toledo Arana, Alejandro Upna; Valle Turrillas, Jaione Upna; Lasa Uzcudun, Íñigo Upna; Solano Goñi, Cristina Upna (American Society for Microbiology, 2013)   Artículo / Artikulua  OpenAccess
      Cyclic di-GMP (c-di-GMP) is a secondary messenger that controls a variety of cellular processes, including the switch between a biofilm and a planktonic bacterial lifestyle. This nucleotide binds to cellular effectors in ...
    • Effect of transcriptional activators SoxS, RobA, and RamA on expression of multidrug efflux pump AcrAB-TolC in enterobacter cloacae 

      Pérez, Astrid; Poza, Margarita; Aranda, Jesús; Latasa Osta, Cristina Upna; Medrano, Francisco Javier; Tomás, María; Romero, Antonio; Lasa Uzcudun, Íñigo Upna; Bou, Germán (American Society for Microbiology, 2012)   Artículo / Artikulua  OpenAccess
      Control of membrane permeability is a key step in regulating the intracellular concentration of antibiotics. Efflux pumps confer innate resistance to a wide range of toxic compounds such as antibiotics, dyes, detergents, ...
    • Evaluation of a Salmonella strain lacking the secondary messenger c-di-GMP and RpoS as a live oral vaccine 

      Latasa Osta, Cristina Upna; Echeverz Sarasúa, Maite Upna; García Ona, Enrique Upna; Burgui Erice, Saioa Upna; Casares, Noelia; Hervás Stubbs, Sandra Upna; Lasarte, Juan José; Lasa Uzcudun, Íñigo Upna; Solano Goñi, Cristina Upna; García Martínez, Begoña Upna; Gil Puig, Carmen Upna (Public Library of Science, 2016)   Artículo / Artikulua  OpenAccess
      Salmonellosis is one of the most important bacterial zoonotic diseases transmitted through the consumption of contaminated food, with chicken and pig related products being key reservoirs of infection. Although numerous ...
    • Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella 

      Solano Goñi, Cristina Upna; García Martínez, Begoña Upna; Latasa Osta, Cristina Upna; Toledo Arana, Alejandro Upna; Zorraquino Salvo, Violeta; Valle Turrillas, Jaione Upna; Casals, Joan; Pedroso, Enrique; Lasa Uzcudun, Íñigo Upna (National Academy of Sciences, 2009)   Artículo / Artikulua  OpenAccess
      Bacteria have developed an exclusive signal transduction system involving multiple diguanylate cyclase and phosphodiesterase domain-containing proteins (GGDEF and EAL/HD-GYP, respectively) that modulate the levels of the ...
    • Overexpression of the recA gene decreases oral but not intraperitoneal fitness of Salmonella enterica 

      Medina-Ruiz, Laura; Campoy Sánchez, Susana; Latasa Osta, Cristina Upna; Cardenas, Paula; Alonso, Juan Carlos; Barbe, Jordi (American Society for Microbiology, 2010)   Artículo / Artikulua  OpenAccess
      Transcription of the Salmonella enterica recA gene is negatively controlled by the LexA protein, the repressor of the SOS response. The introduction of a mutation (recAo6869) in the LexA binding site, in the promoter region ...
    • Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections 

      Vergara Irigaray, Marta Upna; Valle Turrillas, Jaione Upna; Merino, Nekane; Latasa Osta, Cristina Upna; García Martínez, Begoña Upna; Ruiz de los Mozos Aliaga, Igor; Solano Goñi, Cristina Upna; Toledo Arana, Alejandro Upna; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2009)   Artículo / Artikulua  OpenAccess
      Staphylococcus aureus can establish chronic infections on implanted medical devices due to its capacity to form biofilms. Analysis of the factors that assemble cells into a biofilm has revealed the occurrence of strains ...
    • Salmonella biofilm development depends on the phosphorylation status of RcsB 

      Latasa Osta, Cristina Upna; García Martínez, Begoña Upna; Echeverz Sarasúa, Maite Upna; Toledo Arana, Alejandro Upna; Valle Turrillas, Jaione Upna; Campoy Sánchez, Susana; García del Portillo, Francisco; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2012)   Artículo / Artikulua  OpenAccess
      The Rcs phosphorelay pathway is a complex signaling pathway involved in the regulation of many cell surface structures in enteric bacteria. In response to environmental stimuli, the sensor histidine kinase (RcsC) ...