• Amyloid structures as biofilm matrix scaffolds 

      Taglialegna, Agustina Upna; Lasa Uzcudun, Íñigo Upna; Valle Turrillas, Jaione Upna (American Society for Microbiology, 2016)   Artículo / Artikulua  OpenAccess
      Recent insights into bacterial biofilm matrix structures have induced a paradigm shift toward the recognition of amyloid fibers as common building block structures that confer stability to the exopolysaccharide matrix. ...
    • Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor 

      Valle Turrillas, Jaione Upna; Latasa Osta, Cristina Upna; Gil Puig, Carmen Upna; Toledo Arana, Alejandro Upna; Solano Goñi, Cristina Upna; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (Public Library of Science, 2012)   Artículo / Artikulua  OpenAccess
      The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ...
    • Base pairing interaction between 5′- and 3′-UTRs controls icaR mRNA translation in Staphylococcus aureus 

      Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Villanueva San Martín, Maite Upna; Bitarte, Nerea Upna; Saramago, Margarida; Domingues, Susana; Arraiano, Cecilia M.; Fechter, Pierre; Romby, Pascale; Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna; Toledo Arana, Alejandro Upna (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      The presence of regulatory sequences in the 39 untranslated region (39-UTR) of eukaryotic mRNAs controlling RNA stability and translation efficiency is widely recognized. In contrast, the relevance of 39-UTRs in bacterial ...
    • Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection 

      Gil Puig, Carmen Upna; Solano Goñi, Cristina Upna; Burgui Erice, Saioa Upna; Latasa Osta, Cristina Upna; García Martínez, Begoña Upna; Toledo Arana, Alejandro Upna; Lasa Uzcudun, Íñigo Upna; Valle Turrillas, Jaione Upna (American Society for Microbiology, 2014)   Artículo / Artikulua  OpenAccess
      The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ...
    • Biofilm switch and immune response determinants at early stages of infection 

      Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; García Martínez, Begoña Upna; Toledo Arana, Alejandro Upna; Lasa Uzcudun, Íñigo Upna (Elsevier (Cell Press), 2013)   Artículo / Artikulua  OpenAccess
      Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a ...
    • Coordinated cyclic-di-GMP repression of salmonella motility through YcgR and cellulose 

      Zorraquino Salvo, Violeta; García Martínez, Begoña Upna; Latasa Osta, Cristina Upna; Echeverz Sarasúa, Maite Upna; Toledo Arana, Alejandro Upna; Valle Turrillas, Jaione Upna; Lasa Uzcudun, Íñigo Upna; Solano Goñi, Cristina Upna (American Society for Microbiology, 2013)   Artículo / Artikulua  OpenAccess
      Cyclic di-GMP (c-di-GMP) is a secondary messenger that controls a variety of cellular processes, including the switch between a biofilm and a planktonic bacterial lifestyle. This nucleotide binds to cellular effectors in ...
    • The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation 

      Toledo Arana, Alejandro Upna; Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; Arrizubieta Balerdi, María Jesús; Cucarella, Carme; Lamata, Marta; Amorena Zabalza, Beatriz Upna; Leiva, José; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2001)   Artículo / Artikulua  OpenAccess
      The enterococcal surface protein, Esp, is a high-molecular-weight surface protein of unknown function whose frequency is significantly increased among infection-derived Enterococcus faecalis isolates. In this work, a ...
    • Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling 

      Valle Turrillas, Jaione Upna; Burgui Erice, Saioa Upna; Langheinrich, Denise; Gil Puig, Carmen Upna; Solano Goñi, Cristina Upna; Toledo Arana, Alejandro Upna; Helbig, Ralf; Lasagni, Andrés; Lasa Uzcudun, Íñigo Upna (2015)   Artículo / Artikulua  OpenAccess
      Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial ...
    • Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella 

      Solano Goñi, Cristina Upna; García Martínez, Begoña Upna; Latasa Osta, Cristina Upna; Toledo Arana, Alejandro Upna; Zorraquino Salvo, Violeta; Valle Turrillas, Jaione Upna; Casals, Joan; Pedroso, Enrique; Lasa Uzcudun, Íñigo Upna (National Academy of Sciences, 2009)   Artículo / Artikulua  OpenAccess
      Bacteria have developed an exclusive signal transduction system involving multiple diguanylate cyclase and phosphodiesterase domain-containing proteins (GGDEF and EAL/HD-GYP, respectively) that modulate the levels of the ...
    • Genome-wide antisense transcription drives mRNA processing in bacteria 

      Lasa Uzcudun, Íñigo Upna; Toledo Arana, Alejandro Upna; Dobin, Alexander; Villanueva San Martín, Maite Upna; Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R.; Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; Gingeras, Thomas R. (National Academy of Sciences, 2011)   Artículo / Artikulua  OpenAccess
      RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5′ and 3′ untranslated regions, and alternative ...
    • Lack of the PGA exopolysaccharide in Salmonella as an adaptive trait for survival in the host 

      Echeverz Sarasúa, Maite Upna; García Martínez, Begoña Upna; Sabalza Baztán, Amaia; Valle Turrillas, Jaione Upna; Gabaldón Estevan, Juan Antonio; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna (Public Library of Science, 2017)   Artículo / Artikulua  OpenAccess
      Many bacteria build biofilm matrices using a conserved exopolysaccharide named PGA or PNAG (poly-β-1,6-N-acetyl-D-glucosamine). Interestingly, while E. coli and other members of the family Enterobacteriaceae encode the ...
    • Relative contribution of P5 and hap surface proteins to nontypable haemophilus influenzae interplay with the host upper and lower airways 

      Euba, Begoña; Moleres Apilluelo, Javier; Viadas Martínez, Cristina Upna; Ruiz de los Mozos Aliaga, Igor Upna; Valle Turrillas, Jaione Upna; Bengoechea Alonso, José Antonio; Garmendia, Junkal (Public Library of Science, 2015)   Artículo / Artikulua  OpenAccess
      Nontypable Haemophilus influenzae (NTHi) is a major cause of opportunistic respiratory tract disease, and initiates infection by colonizing the nasopharynx. Bacterial surface proteins play determining roles in the ...
    • Salmonella biofilm development depends on the phosphorylation status of RcsB 

      Latasa Osta, Cristina Upna; García Martínez, Begoña Upna; Echeverz Sarasúa, Maite Upna; Toledo Arana, Alejandro Upna; Valle Turrillas, Jaione Upna; Campoy Sánchez, Susana; García del Portillo, Francisco; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2012)   Artículo / Artikulua  OpenAccess
      The Rcs phosphorelay pathway is a complex signaling pathway involved in the regulation of many cell surface structures in enteric bacteria. In response to environmental stimuli, the sensor histidine kinase (RcsC) ...
    • Sensory deprivation in Staphylococcus aureus 

      Villanueva San Martín, Maite Upna; García Martínez, Begoña Upna; Valle Turrillas, Jaione Upna; Rapún Araiz, Beatriz; Ruiz de los Mozos Aliaga, Igor Upna; Solano Goñi, Cristina Upna; Martí, Miguel; Penadés, José R.; Toledo Arana, Alejandro Upna; Lasa Uzcudun, Íñigo Upna (Springer Nature, 2018)   Artículo / Artikulua  OpenAccess
      Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show ...
    • Staphylococcal Bap proteins build amyloid scaffold biofilm matrices in response to environmental signals 

      Taglialegna, Agustina Upna; Navarro, Susanna; Ventura, Salvador; Garnett, James A.; Matthews, Steve; Penadés, José R.; Lasa Uzcudun, Íñigo Upna; Valle Turrillas, Jaione Upna (Public Library of Science, 2016)   Artículo / Artikulua  OpenAccess
      Major components of the biofilm matrix scaffold are proteins that assemble to create a unified structure that maintain bacteria attached to each other and to surfaces. We provide evidence that a surface protein present in ...
    • Study of the molecular mechanisms underlying Bap-mediated cell-cell interactions in Staphylococcus aureus 

      Taglialegna, Agustina Upna (2016)   Tesis doctoral / Doktoretza tesia  OpenAccess
      La mayoría de los microorganismos son capaces de vivir en comunidades sésiles, siendo esta forma de crecimiento bastante más frecuente que la forma de vida planctónica. En estas comunidades microbianas, conocidas como ...