Now showing items 1-7 of 7

    • Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment 

      Celay Leoz, Ion; Blanco Luquin, Idoia; Lázcoz, Paula Upna; Rotinen Díaz, Mirja Sofia; Castresana, Javier S.; Encío Martínez, Ignacio Upna (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers ...
    • A diphenyldiselenide derivative induces autophagy via JNK in HTB-54 lung cancer cells 

      Díaz, Marta; González, Roncesvalles; Plano, Daniel; Palop, Juan Antonio; Sanmartín, Carmen; Encío Martínez, Ignacio Upna (Wiley, 2017)   Artículo / Artikulua  OpenAccess
      Symmetric aromatic diselenides are potential anticancer agents with strong cytotoxic activity. In this study, the in vitro anticancer activities of a novel series of diarylseleno derivatives from the diphenyldiselenide ...
    • Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma 

      Lázcoz, Paula Upna; Muñoz, Jorge; Nistal, Manuel; Pestaña, Ángel; Encío Martínez, Ignacio Upna; Sáez Castresana, Javier (BioMed Central, 2006)   Artículo / Artikulua  OpenAccess
      Background: Epigenetic alterations and loss of heterozygosity are mechanisms of tumor suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has recently been documented. RASSF1A, on 3p21.3, ...
    • Novel methylselenoesters as antiproliferative agents 

      Díaz Argelich, Nuria; Encío Martínez, Ignacio Upna; Plano, Daniel; Fernandes, Aristi P.; Palop, Juan Antonio; Sanmartín, Carmen (MDPI, 2017)   Artículo / Artikulua  OpenAccess
      Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the biological effects of Se compounds are exerted by their metabolites, with methylselenol (CH3SeH) being one of the key executors. In this ...
    • Novel selenadiazole derivatives as selective antitumor and radical scavenging agents 

      Ruberte, Ana Carolina; Plano, Daniel; Encío Martínez, Ignacio Upna; Aydillo, Carlos; Sharma, Arun K.; Sanmartín, Carmen (Elsevier, 2018)   Artículo / Artikulua
      Twenty-seven novel benzo[c][1,2,5]selenadiazole-5-carboxylic acid (BSCA) derivatives were designed and synthesized. Anti-proliferative activity of these structures was tested in vitro against a panel of five human cancer ...
    • Synthesis and pharmacological screening of several aroyl and heteroaroyl selenylacetic acid derivatives as cytotoxic and antiproliferative agents 

      Sanmartín, Carmen; Plano, Daniel; Domínguez, Enrique; Font, María; Calvo, Alfonso; Prior, Celia; Encío Martínez, Ignacio Upna; Palop, Juan Antonio (MDPI, 2009)   Artículo / Artikulua  OpenAccess
      The synthesis and cytotoxic activity of a series of twenty six aroyl and heteroaroyl selenylacetic acid derivatives of general formula Ar-CO-Se-CH(2)-COOH or Heterar-CO-Se-CH(2)-COOH are reported. The synthesis was carried ...
    • Transcriptional regulation of type 11 17β-hydroxysteroid dehydrogenase expression in prostate cancer cells 

      Rotinen Díaz, Mirja Sofia; Villar Bécares, Joaquín; Celay Leoz, Ion; Serrano Mendioroz, Irantzu; Notario, Vicente; Encío Martínez, Ignacio Upna (Elsevier, 2011)   Artículo / Artikulua  OpenAccess
      Type 11 Hydroxysteroid (17-beta) dehydrogenase (HSD17B11) catalyzes the conversion of 5α-androstan-3α,17β-diol into androsterone suggesting that it may play an important role in androgen metabolism. We previously described ...