• Resveratrol therapeutics combines both antimicrobial and immunomodulatory properties against respiratory infection by nontypeable Haemophilus influenzae 

      Euba, Begoña; López López, Nahikari; Rodríguez Arce, Irene; Fernández Calvet, Ariadna; Barberán, Montserrat; Caturla, Nuria; Martí, Sara; Díez Martínez, Roberto; Garmendia, Junkal (Springer Nature, 2017)   Artículo / Artikulua  OpenAccess
      The respiratory pathogen nontypeable Haemophilus influenzae (NTHi) is an important cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) that requires efficient treatments. A previous screening ...
    • RinA controls phage-mediated packaging and transfer of virulence genes in gram-positive bacteria 

      Ferrer, María Desamparados; Quiles Puchalt, Nuria; Harwich, Michael D.; Tormo Más, María Ángeles; Campoy Sánchez, Susana; Barbé, Jordi; Lasa Uzcudun, Íñigo Upna; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Oxford University Press, 2011)   Artículo / Artikulua  OpenAccess
      Phage-mediated transfer of microbial genetic elements plays a crucial role in bacterial life style and evolution. In this study, we identify the RinA family of phage-encoded proteins as activators required for transcription ...
    • Role of bacterial surface structures on the interaction of Klebsiella pneumoniae with phagocytes 

      March, Catalina; Cano, Victoria; Moranta, David; Llobet, Enrique; Pérez Gutiérrez, Camino; Tomás, Juan M.; Suárez, Teresa; Garmendia, Junkal; Bengoechea Alonso, José Antonio (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      Phagocytosis is a key process of the immune system. The human pathogen Klebsiella pneumoniae is a well known example of a pathogen highly resistant to phagocytosis. A wealth of evidence demonstrates that the capsule ...
    • Role of biofilm-associated protein bap in the pathogenesis of bovine Staphylococcus aureus 

      Cucarella, Carme; Tormo Más, María Ángeles; Ubeda, Carles; Trotonda, María Pilar; Monzon, Marta; Peris, Cristòfol; Amorena Zabalza, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Penadés, José R. (American Society for Microbiology, 2004)   Artículo / Artikulua  OpenAccess
      Staphylococcus aureus is a common cause of intramammary infections, which frequently become chronic, associated with the ability of the bacteria to produce biofilm. Here, we report a relationship between the ability to ...
    • Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer 

      Maiques, Elisa; Ubeda, Carles; Tormo Más, María Ángeles; Ferrer, María Desamparados; Lasa Uzcudun, Íñigo Upna; Novick, Richard P.; Penadés, José R. (American Society for Microbiology, 2007)   Artículo / Artikulua  OpenAccess
      SaPIbov2 is a member of the SaPI family of staphylococcal pathogenicity islands and is very closely related to SaPIbov1. Typically, certain temperate phages can induce excision and replication of one or more of these islands ...
    • Role of the Omp25/Omp31 family in outer membrane properties and virulence of Brucella ovis 

      Caro-Hernandez, Paola; Fernandez-Lago, Luis; Miguel, María Jesús de; Martin-Martin, Ana I.; Cloeckaert, Axel; Grilló Dolset, María Jesús; Vizcaíno, Nieves (American Society for Microbiology, 2007)   Artículo / Artikulua  OpenAccess
      The genes coding for the five outer membrane proteins (OMPs) of the Omp25/Omp31 family expected to be located in the outer membrane (OM) of rough virulent Brucella ovis PA were inactivated to evaluate their role in virulence ...
    • Routes of transmission and consequences of small ruminant lentiviruses (SRLVs) infection and eradication schemes 

      Peterhans, Ernst; Greenland, Tim; Badiola, Juan José; Harkiss, Gordon; Bertoni, Giuseppe; Amorena Zabalza, Beatriz Upna; Eliaszewicz, Muriel; Juste, Ramón; Krassnig, Renate; Lafont, Jean Pierre (EDP Sciences, 2004)   Artículo / Artikulua  OpenAccess
      Small ruminant lentiviruses (SRLV = maedi-visna in sheep and caprine arthritis encephalitis in goats) are distributed throughout most countries of the world, particularly Europe. Laboratories from 16 European countries ...
    • Salmonella biofilm development depends on the phosphorylation status of RcsB 

      Latasa Osta, Cristina Upna; García Martínez, Begoña Upna; Echeverz Sarasúa, Maite Upna; Toledo Arana, Alejandro Upna; Valle Turrillas, Jaione Upna; Campoy Sánchez, Susana; García del Portillo, Francisco; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2012)   Artículo / Artikulua  OpenAccess
      The Rcs phosphorelay pathway is a complex signaling pathway involved in the regulation of many cell surface structures in enteric bacteria. In response to environmental stimuli, the sensor histidine kinase (RcsC) ...
    • SarA is an essential positive regulator of Staphylococcus epidermidis biofilm development 

      Tormo Más, María Ángeles; Martí, Miguel; Valle Turrillas, Jaione Upna; Manna, Adhar C.; Cheung, Ambrose L.; Lasa Uzcudun, Íñigo Upna; Penadés, José R. (American Society for Microbiology, 2005)   Artículo / Artikulua  OpenAccess
      Staphylococcus epidermidis biofilm formation is associated with the production of the polysaccharide intercellular adhesin (PIA)--poly-N-acetylglucosamine polysaccharide (PNAG) by the products of the icaADBC operon. ...
    • SarA positively controls Bap-dependent biofilm formation in Staphylococcus aureus 

      Trotonda, María Pilar; Manna, Adhar C.; Cheung, Ambrose L.; Lasa Uzcudun, Íñigo Upna; Penadés, José R. (American Society for Microbiology, 2005)   Artículo / Artikulua  OpenAccess
      The biofilm-associated protein Bap is a staphylococcal surface protein involved in biofilm formation. We investigated the influence of the global regulatory locus sarA on bap expression and Bap-dependent biofilm formation ...
    • Sensitivity of the ISO 6579:2002/Amd 1:2007 standard method for detection of Salmonella spp. on mesenteric lymph nodes from slaughter pigs 

      Mainar Jaime, Raúl Carlos; Andrés, S.; Vico, J. P.; San Román Aberasturi, Beatriz Upna; Garrido, Victoria Upna; Grilló Dolset, María Jesús (American Society for Microbiology, 2012)   Artículo / Artikulua  OpenAccess
      The ISO 6579:2002/Amd 1:2007 (ISO) standard has been the bacteriological standard method used in the European Union for the detection of Salmonella spp. in pig mesenteric lymph nodes (MLN), but there are no published ...
    • Sensory deprivation in Staphylococcus aureus 

      Villanueva San Martín, Maite Upna; García Martínez, Begoña Upna; Valle Turrillas, Jaione Upna; Rapún Araiz, Beatriz; Ruiz de los Mozos Aliaga, Igor Upna; Solano Goñi, Cristina Upna; Martí, Miguel; Penadés, José R.; Toledo Arana, Alejandro Upna; Lasa Uzcudun, Íñigo Upna (Springer Nature, 2018)   Artículo / Artikulua  OpenAccess
      Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show ...
    • Sequence diversity of rulA among natural isolates of Pseudomonas syringae and effect on function of rulAB-mediated UV radiation tolerance 

      Sundin, George W.; Jacobs, Janette L.; Murillo Martínez, Jesús Upna (American Society for Microbiology, 2000)   Artículo / Artikulua  OpenAccess
      The rulAB locus confers tolerance to UV radiation and is borne on plasmids of the pPT23A family in Pseudomonas syringae. We sequenced 14 rulA alleles from P. syringae strains representing seven pathovars and found sequence ...
    • Sf29 Gene of Spodoptera frugiperda multiple nucleopolyhedrovirus is a viral factor that determines the number of virions in occlusion bodies 

      Simón de Goñi, Oihane; Williams, Trevor Upna; Asensio, Aarón C.; Ros Terés, Sarhay; Gaya Cacho, Andrea; Caballero Murillo, Primitivo Upna; Possee, Robert D. (American Society for Microbiology, 2008)   Artículo / Artikulua  OpenAccess
      The genome of Spodoptera frugiperda multiple nucleopolyhedrovirus (NPV) was inserted into a bacmid (Sfbac) and used to produce a mutant lacking open reading frame 29 (Sf29null). Sf29null bacmid DNA was able to generate ...
    • The sf32 unique gene of spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV) is a non-essential gene that could be involved in nucleocapsid organization in occlusion-derived virions 

      Beperet Arive, Inés Upna; Barrera Cubillos, Gloria Patricia; Simón de Goñi, Oihane; Williams, Trevor Upna; López Ferber, Miguel; Gasmi, Laila; Herrero, Salvador; Caballero Murillo, Primitivo Upna (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      A recombinant virus lacking the sf32 gene (Sf32null), unique to the Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV), was generated by homologous recombination from a bacmid comprising the complete viral genome ...
    • Simultaneous infections by different Salmonella strains in mesenteric lymph nodes of finishing pigs 

      Garrido, Victoria Upna; Sánchez Alarcón, Samanta Rita; San Román Aberasturi, Beatriz Upna; Zabalza Baranguá, Ana Upna; Díaz Tendero, Yasmín; Frutos, Cristina de; Mainar Jaime, Raúl Carlos; Grilló Dolset, María Jesús (BioMed Central, 2014)   Artículo / Artikulua  OpenAccess
      Background: Salmonellosis is a major worldwide zoonosis, and Salmonella-infected finishing pigs are considered one of the major sources of human infections in developed countries. Baseline studies on salmonellosis ...
    • Small ruminant lentiviruses: genetic variability, tropism and diagnosis 

      Ramírez, Hugo Upna; Reina Arias, Ramsés Upna; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna; Martínez, Humberto A. (MDPI, 2013)   Artículo / Artikulua  OpenAccess
      Small ruminant lentiviruses (SRLV) cause a multisystemic chronic disease affecting animal production and welfare. SRLV infections are spread across the world with the exception of Iceland. Success in controlling SRLV spread ...
    • Small ruminant macrophage polarization may play a pivotal role on lentiviral infection 

      Crespo, Helena Upna; Bertolotti, Luigi; Juganaru, Magda; Glaría Ezquer, Idoia Upna; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Rosati, Sergio; Reina Arias, Ramsés Upna (BioMed Central, 2013)   Artículo / Artikulua  OpenAccess
      Small ruminant lentiviruses (SRLV) infect the monocyte/macrophage lineage inducing a long-lasting infection affecting body condition, production and welfare of sheep and goats all over the world. Macrophages play a pivotal ...
    • Spatial distribution and risk factors of brucellosis in Iberian wild ungulates 

      Muñoz Álvaro, Pilar María; Boadella, Mariana; Arnal, Maricruz; Miguel, María Jesús de; Revilla, Miguel; Martínez, David; Vicente, Joaquín; Acevedo, Pelayo; Oleaga, Álvaro; Ruiz Fons, Francisco; Marín, Clara M.; Prieto, José M.; Fuente, José de la; Barral, Marta; Barberán, Montserrat; Fernández de Luco, Daniel; Blasco, José María Upna; Gortázar, Christian (BioMed Central, 2010)   Artículo / Artikulua  OpenAccess
      Background: The role of wildlife as a brucellosis reservoir for humans and domestic livestock remains to be properly established. The aim of this work was to determine the aetiology, apparent prevalence, spatial distribution ...
    • Stability of a Spodoptera frugiperda nucleopolyhedrovirus deletion recombinant during serial passage in insects 

      Simón de Goñi, Oihane; Williams, Trevor Upna; Possee, Robert D.; López Ferber, Miguel; Caballero Murillo, Primitivo Upna (American Society for Microbiology, 2009)   Artículo / Artikulua  OpenAccess
      The stabilities of the Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV) complete genome bacmid (Sfbac) and a deletion recombinant (Sf29null) in which the Sf29 gene was replaced by a kanamycin resistance ...