Now showing items 56-75 of 159

    • Expression of the biofilm-associated protein interferes with host protein receptors of Staphylococcus aureus and alters the infective process 

      Cucarella, Carme; Tormo Más, María Ángeles; Knecht, Erwin; Amorena Zabalza, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Foster, Timothy J.; Penadés, José R. (American Society for Microbiology, 2002)   Artículo / Artikulua  OpenAccess
      The adherence of Staphylococcus aureus to soluble proteins and extracellular-matrix components of the host is one of the key steps in the pathogenesis of staphylococcal infections. S. aureus presents a family of adhesins ...
    • Extensive rearing hinders Maedi-Visna Virus (MVV) infection in sheep 

      Leginagoikoa, Iratxe; Juste, Ramón; Barandika, Jesse; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna; Luján, Lluís; Badiola, Juan José; Berriatua, Eduardo (EDP Sciences, 2006)   Artículo / Artikulua  OpenAccess
      Maedi-Visna Virus (MVV) seroprevalence and its relationship with housing and mode of rearing of replacement ewe-lambs was investigated in 38 non-randomly selected sheep-flocks in Spain. They included extensive lamb-producing ...
    • The extradomain a of fibronectin enhances the efficacy of lipopolysaccharide defective Salmonella bacterins as vaccines in mice 

      San Román Aberasturi, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Lasarte, Juan José; Grilló Dolset, María Jesús; Garrido, Victoria Upna; Muñoz Álvaro, Pilar María; Arribillaga, Laura; García Martínez, Begoña Upna; Andrés, Ximena de; Zabaleta, Virginia Upna; Mansilla, Cristina; Farrán Blanch, Inmaculada Upna (BioMed Central, 2012)   Artículo / Artikulua  OpenAccess
      The Extradomain A from fibronectin (EDA) has an immunomodulatory role as fusion protein with viral and tumor antigens, but its effect when administered with bacteria has not been assessed. Here, we investigated the adjuvant ...
    • The fusion of Toxoplasma gondii SAG1 vaccine candidate to Leishmania infantum heat shock protein 83-kDa improves expression levels in tobacco chloroplasts 

      Albarracin, R; Laguía Becher, M; Farrán Blanch, Inmaculada Upna; Sander, Valeria; Corigliano, M; Yácono, María del L.; Pariani, S; Sánchez, E; Veramendi Charola, Jon Upna; Clemente, Marina (Wiley, 2015)   Artículo / Artikulua  OpenAccess
      Chloroplast transformation technology has emerged as an alternative platform offering many advantages over nuclear transformation. SAG1 is the main surface antigen of the intracellular parasite Toxoplasma gondii and a ...
    • Gender-mediated differences in vertical transmission of a nucleopolyhedrovirus 

      Virto Garayoa, Cristina Upna; Zárate Chaves, Carlos Andrés; López Ferber, Miguel; Murillo Pérez, Rosa Upna; Caballero Murillo, Primitivo Upna; Williams, Trevor Upna (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      With the development of sensitive molecular techniques for detection of low levels of asymptomatic pathogens, it becoming clear that vertical transmission is a common feature of some insect pathogenic viruses, and likely ...
    • Genetic and isotope ratio mass spectrometric evidence for the occurrence of starch degradation and cycling in illuminated Arabidopsis leaves 

      Baslam, Marouane; Baroja Fernández, Edurne Upna; Ricarte Bermejo, Adriana; Sánchez López, Ángela María; Aranjuelo Michelena, Iker; Bahaji, Abdellatif; Muñoz Pérez, Francisco José; Almagro Zabalza, Goizeder Upna; Pujol, Pablo; Galarza, Regina; Teixidor, Pilar; Pozueta Romero, Javier Upna (Public Library of Science, 2017)   Artículo / Artikulua  OpenAccess
      Although there is a great wealth of data supporting the occurrence of simultaneous synthesis and breakdown of storage carbohydrate in many organisms, previous 13CO2 pulse-chase based studies indicated that starch degradation ...
    • Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella 

      Solano Goñi, Cristina Upna; García Martínez, Begoña Upna; Latasa Osta, Cristina Upna; Toledo Arana, Alejandro Upna; Zorraquino Salvo, Violeta; Valle Turrillas, Jaione Upna; Casals, Joan; Pedroso, Enrique; Lasa Uzcudun, Íñigo Upna (National Academy of Sciences, 2009)   Artículo / Artikulua  OpenAccess
      Bacteria have developed an exclusive signal transduction system involving multiple diguanylate cyclase and phosphodiesterase domain-containing proteins (GGDEF and EAL/HD-GYP, respectively) that modulate the levels of the ...
    • Genome expression profiling-based identification and administration efficacy of host-directed antimicrobial drugs against respiratory infection by nontypeable Haemophilus influenzae 

      Euba, Begoña; Moleres Apilluelo, Javier; Segura, Víctor; Viadas Martínez, Cristina Upna; Morey Sancho, Pau; Moranta, David; Leiva, José; Torres, Juan de; Bengoechea Alonso, José Antonio; Garmendia García, Juncal (American Society for Microbiology, 2015)   Artículo / Artikulua  OpenAccess
      Therapies that are safe, effective, and not vulnerable to developing resistance are highly desirable to counteract bacterial infections. Host-directed therapeutics is an antimicrobial approach alternative to conventional ...
    • Genome-wide antisense transcription drives mRNA processing in bacteria 

      Lasa Uzcudun, Íñigo Upna; Toledo Arana, Alejandro Upna; Dobin, Alexander; Villanueva San Martín, Maite Upna; Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R.; Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; Gingeras, Thomas R. (National Academy of Sciences, 2011)   Artículo / Artikulua  OpenAccess
      RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5′ and 3′ untranslated regions, and alternative ...
    • Genome-wide screening of genes whose enhanced expression affects glycogen accumulation in Escherichia coli 

      Eydallin, Gustavo Upna; Montero Macarro, Manuel Upna; Almagro Zabalza, Goizeder Upna; Sesma Pascual, María Teresa Upna; Viale, Alejandro M. Upna; Muñoz Pérez, Francisco José; Rahimpour, Mehdi; Baroja Fernández, Edurne Upna; Pozueta Romero, Javier Upna (Oxford University Press, 2010)   Artículo / Artikulua  OpenAccess
      Using a systematic and comprehensive gene expression library (the ASKA library), we have carried out a genome-wide screening of the genes whose increased plasmid-directed expression affected glycogen metabolism in Escherichia ...
    • Genomic sequences of five Helicoverpa armigera nucleopolyhedrovirus genotypes from Spain that differ in their insecticidal properties 

      Arrizubieta Celaya, Maite; Simón de Goñi, Oihane; Williams, Trevor Upna; Caballero Murillo, Primitivo Upna (American Society for Microbiology, 2015)   Artículo / Artikulua  OpenAccess
      Helicoverpa armigera nucleopolyhedrovirus (HearNPV) has proved effective as the basis for various biological insecticides. Complete genome sequences of five Spanish HearNPV genotypes differed principally in the homologous ...
    • Glycogen phosphorylase, the product of the glgP Gene, catalyzes glycogen breakdown by removing glucose units from the nonreducing ends in Escherichia coli 

      Alonso-Casajus, Nora; Dauvillee, David; Viale, Alejandro M. Upna; Muñoz Pérez, Francisco José; Baroja Fernández, Edurne Upna; Morán Zorzano, María Teresa; Eydallin, Gustavo Upna; Ball, Steven; Pozueta Romero, Javier Upna (American Society for Microbiology, 2006)   Artículo / Artikulua  OpenAccess
      To understand the biological function of bacterial glycogen phosphorylase (GlgP), we have produced and characterized Escherichia coli cells with null or altered glgP expression. glgP deletion mutants (ΔglgP) totally lacked ...
    • High-density seedling expression system for the production of bioactive human cardiotrophin-1, a potential therapeutic cytokine, in transgenic tobacco chloroplasts 

      Farrán Blanch, Inmaculada Upna; Río-Manterola, Francisco; Íñiguez, María; Gárate, Sonia; Prieto, Jesús; Mingo Castel, Ángel (Wiley, 2008)   Artículo / Artikulua  OpenAccess
      Histidine‐tagged human cardiotrophin‐1 (hCT‐1), a recently discovered cytokine with excellent therapeutic potential, was expressed in tobacco chloroplasts under the transcriptional and translational control of two different ...
    • HPLC-MS/MS analyses show that the near-starchless aps1 and pgm leaves accumulate wild type levels of ADPglucose: further evidence for the occurrence of important ADPglucose biosynthetic pathway(s) alternative to the pPGI-pPGM-AGP pathway 

      Bahaji, Abdellatif; Baroja Fernández, Edurne Upna; Sánchez López, Ángela María; Muñoz Pérez, Francisco José; Li, Jun; Almagro Zabalza, Goizeder Upna; Montero Macarro, Manuel Upna; Pujol, Pablo; Galarza, Regina; Kaneko, Kentaro; Oikawa, Kazusato; Wada, Kaede; Mitsui, Toshiaki; Pozueta Romero, Javier Upna (Public Library of Science, 2014)   Artículo / Artikulua  OpenAccess
      In leaves, it is widely assumed that starch is the end-product of a metabolic pathway exclusively taking place in the chloroplast that (a) involves plastidic phosphoglucomutase (pPGM), ADPglucose (ADPG) pyrophosphorylase ...
    • Human papillomavirus L1 protein expressed in tobacco chloroplasts self-assembles into virus-like particles that are highly immunogenic 

      Fernández San Millán, Alicia Upna; Martín Ortigosa, Susana; Hervás Stubbs, Sandra Upna; Corral-Martínez, Patricia; Seguí-Simarro, José M.; Gaétan, Julien; Coursaget, Pierre; Veramendi Charola, Jon Upna (Wiley, 2008)   Artículo / Artikulua  OpenAccess
      Cervical cancer is the second most prevalent cancer in women worldwide. It is linked to infection with human papillomavirus (HPV). As the virus cannot be propagated in culture, vaccines based on virus‐like particles have ...
    • Iberian red deer: paraphyletic nature at mtDNA but nuclear markers support its genetic identity 

      Carranza, Juan; Salinas, María; Andrés Cara, Damián de Upna; Pérez González, Javier (Wiley, 2016)   Artículo / Artikulua  OpenAccess
      Red deer populations in the Iberian glacial refugium were the main source for postglacial recolonization and subspecific radiation in north-western Europe. However, the phylogenetic history of Iberian red deer (Cervus ...
    • Identification of lptA, lpxE, and lpxO, three genes involved in the remodeling of Brucella cell envelope 

      Conde Álvarez, Raquel; Palacios Chaves, Leyre; Gil Ramírez, Yolanda Upna; Salvador Bescós, Miriam; Bárcena Varela, Marina; Aragón Aranda, Beatriz; Martínez Gómez, Estrella; Zúñiga Ripa, Amaia; Miguel López, María Jesús de; Bartholomew, Toby Leigh; Hanniffy, Sean; Grilló Dolset, María Jesús; Vences Guzmán, Miguel Ángel; Bengoechea Alonso, José Antonio; Arce Gorvel, Vilma; Gorvel, Jean-Pierre; Moriyón Uría, Ignacio; Iriarte, Maite (Frontiers Media, 2018)   Artículo / Artikulua  OpenAccess
      The brucellae are facultative intracellular bacteria that cause a worldwide extended zoonosis. One of the pathogenicity mechanisms of these bacteria is their ability to avoid rapid recognition by innate immunity because ...
    • Identification of the ovine mannose receptor and its possible role in Visna/Maedi virus infection 

      Crespo, Helena Upna; Reina Arias, Ramsés Upna; Glaría Ezquer, Idoia Upna; Ramírez, Hugo Upna; Andrés, Ximena de; Jauregui, Paula; Luján, Lluís; Martínez Pomares, Luisa; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna (BioMed Central, 2011)   Artículo / Artikulua  OpenAccess
      This study aims to characterize the mannose receptor (MR) gene in sheep and its role in ovine visna/maedi virus (VMV) infection. The deduced amino acid sequence of ovine MR was compatible with a transmembrane protein having ...
    • Iflavirus increases its infectivity and physical stability in association with baculovirus 

      Jakubowska, Agata K.; Murillo Pérez, Rosa Upna; Carballo Palos, Arkaitz; Williams, Trevor Upna; Lent, Jan W. M. van; Caballero Murillo, Primitivo Upna; Herrero, Salvador (PeerJ, 2016)   Artículo / Artikulua  OpenAccess
      Virus transmission and the prevalence of infection depend on multiple factors, including the interaction with other viral pathogens infecting the same host. In this study, active replication of an iflavirus, Spodoptera ...
    • Immunization against small ruminant lentiviruses 

      Reina Arias, Ramsés Upna; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna (MDPI, 2013)   Artículo / Artikulua  OpenAccess
      Multisystemic disease caused by Small Ruminant Lentiviruses (SRLV) in sheep and goats leads to production losses, to the detriment of animal health and welfare. This, together with the lack of treatments, has triggered ...