• Adenosine diphosphate glucose pyrophosphatase: a plastidial phosphodiesterase that prevents starch biosynthesis 

      Rodríguez López, Milagros; Baroja Fernández, Edurne Upna; Zandueta Criado, Aitor; Pozueta Romero, Javier Upna (National Academy of Sciences, 2000)   Artículo / Artikulua  OpenAccess
      A distinct phosphodiesterasic activity (EC 3.1.4) was found in both mono- and dicotyledonous plants that catalyzes the hydrolytic breakdown of ADPglucose (ADPG) to produce equimolar amounts of glucose-1-phosphate and AMP. ...
    • Adenosine diphosphate sugar pyrophosphatase prevents glycogen biosynthesis in Escherichia coli 

      Moreno Bruna, Beatriz; Baroja Fernández, Edurne Upna; Muñoz Pérez, Francisco José; Bastarrica Berasategui, Ainara; Zandueta Criado, Aitor; Rodríguez López, Milagros; Lasa Uzcudun, Íñigo Upna; Akazawa, Takashi; Pozueta Romero, Javier Upna (National Academy of Sciences, 2001)   Artículo / Artikulua  OpenAccess
      An adenosine diphosphate sugar pyrophosphatase (ASPPase, EC 3.6.1.21) has been characterized by using Escherichia coli. This enzyme, whose activities in the cell are inversely correlated with the intracellular glycogen ...
    • Amyloid structures as biofilm matrix scaffolds 

      Taglialegna, Agustina Upna; Lasa Uzcudun, Íñigo Upna; Valle Turrillas, Jaione Upna (American Society for Microbiology, 2016)   Artículo / Artikulua  OpenAccess
      Recent insights into bacterial biofilm matrix structures have induced a paradigm shift toward the recognition of amyloid fibers as common building block structures that confer stability to the exopolysaccharide matrix. ...
    • Analagous population structures for two alphabaculoviruses highlight a functional role for deletion mutants 

      Serrano García, Amaya Upna; Williams, Trevor Upna; Simón de Goñi, Oihane; López Ferber, Miguel; Caballero Murillo, Primitivo Upna; Muñoz, Delia Upna (American Society for Microbiology, 2012)   Artículo / Artikulua  OpenAccess
      A natural Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) isolate from Florida shares a strikingly similar genotypic composition to that of a natural Spodoptera frugiperda MNPV (SfMNPV) isolate from Nicaragua. ...
    • Apoptosis, toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens 

      Martínez, Isidoro; Oliveros, Juan C.; Cuesta, Isabel; Barrera, Jorge de la; Ausina, Vicente; Casals, Cristina; Lorenzo, Alba de; García, Ernesto; García Fojeda, Belén; Garmendia García, Juncal; González Nicolau, Mar; Lacoma, Alicia; Menéndez, Margarita; Moranta, David; Nieto, Amelia; Ortín, Juan; Pérez González, Alicia; Prat, Cristina; Ramos Sevillano, Elisa; Regueiro, Verónica; Rodríguez Frandsen, Ariel; Solís, Dolores; Yuste, José E.; Bengoechea Alonso, José Antonio; Melero, José A. (Frontiers Media, 2017)   Artículo / Artikulua  OpenAccess
      Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by ...
    • B regulates IS256-mediated Staphylococcus aureus biofilm phenotypic variation 

      Valle Turrillas, Jaione Upna; Vergara Irigaray, Marta Upna; Merino, Nekane; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2007)   Artículo / Artikulua  OpenAccess
      Biofilm formation in Staphylococcus aureus is subject to phase variation, and biofilm-negative derivatives emerge sporadically from a biofilm-positive bacterial population. To date, the only known mechanism for generating ...
    • Bacillus thuringiensis toxins: an overview of their biocidal activity 

      Palma Dovis, Leopoldo Upna; Muñoz, Delia Upna; Berry, Colin; Murillo Martínez, Jesús Upna; Caballero Murillo, Primitivo Upna (MDPI, 2014)   Artículo / Artikulua  OpenAccess
      Bacillus thuringiensis (Bt) is a Gram positive, spore-forming bacterium that synthesizes parasporal crystalline inclusions containing Cry and Cyt proteins, some of which are toxic against a wide range of insect orders, ...
    • Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor 

      Valle Turrillas, Jaione Upna; Latasa Osta, Cristina Upna; Gil Puig, Carmen Upna; Toledo Arana, Alejandro Upna; Solano Goñi, Cristina Upna; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (Public Library of Science, 2012)   Artículo / Artikulua  OpenAccess
      The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ...
    • Bap, a Staphylococcus aureus surface protein involved in biofilm formation 

      Cucarella, Carme; Solano Goñi, Cristina Upna; Valle Turrillas, Jaione Upna; Amorena Zabalza, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Penadés, José R. (American Society for Microbiology, 2001)   Artículo / Artikulua  OpenAccess
      Identification of new genes involved in biofilm formation is needed to understand the molecular basis of strain variation and the pathogenic mechanisms implicated in chronic staphylococcal infections. A biofilm-producing ...
    • Base pairing interaction between 5′- and 3′-UTRs controls icaR mRNA translation in Staphylococcus aureus 

      Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Villanueva San Martín, Maite Upna; Bitarte, Nerea Upna; Saramago, Margarida; Domingues, Susana; Arraiano, Cecilia M.; Fechter, Pierre; Romby, Pascale; Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna; Toledo Arana, Alejandro Upna (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      The presence of regulatory sequences in the 39 untranslated region (39-UTR) of eukaryotic mRNAs controlling RNA stability and translation efficiency is widely recognized. In contrast, the relevance of 39-UTRs in bacterial ...
    • Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus 

      Maiques, Elisa; Ubeda, Carles; Campoy Sánchez, Susana; Salvador, Noelia; Lasa Uzcudun, Íñigo Upna; Novick, Richard P.; Barbé, Jordi; Penadés, José R. (American Society for Microbiology, 2006)   Artículo / Artikulua  OpenAccess
      Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer ...
    • Biofilm dispersion and quorum sensing 

      Solano Goñi, Cristina Upna; Echeverz Sarasúa, Maite Upna; Lasa Uzcudun, Íñigo Upna (Elsevier, 2014)   Artículo / Artikulua  OpenAccess
      Biofilm development and quorum sensing are closely interconnected processes. Biofilm formation is a cooperative group behaviour that involves bacterial populations living embedded in a self produced extracellular matrix. ...
    • Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection 

      Gil Puig, Carmen Upna; Solano Goñi, Cristina Upna; Burgui Erice, Saioa Upna; Latasa Osta, Cristina Upna; García Martínez, Begoña Upna; Toledo Arana, Alejandro Upna; Lasa Uzcudun, Íñigo Upna; Valle Turrillas, Jaione Upna (American Society for Microbiology, 2014)   Artículo / Artikulua  OpenAccess
      The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ...
    • Biofilm switch and immune response determinants at early stages of infection 

      Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; García Martínez, Begoña Upna; Toledo Arana, Alejandro Upna; Lasa Uzcudun, Íñigo Upna (Elsevier (Cell Press), 2013)   Artículo / Artikulua  OpenAccess
      Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a ...
    • Both free indole-3-acetic acid and photosynthetic performance are important players in the response of Medicago truncatula to urea and ammonium nutrition under axenic conditions 

      Esteban Terradillos, Raquel; Royo Castillejo, Beatriz; Urarte Rodríguez, Estíbaliz; Zamarreño, Ángel M.; García Mina, José M.; Morán Juez, José Fernando Upna (Frontiers Media, 2016)   Artículo / Artikulua  OpenAccess
      We aimed to identify the early stress response and plant performance of Medicago truncatula growing in axenic medium with ammonium or urea as the sole source of nitrogen, with respect to nitrate-based nutrition. Biomass ...
    • Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern 

      Palacios Chaves, Leyre; Conde Álvarez, Raquel; Gil Ramírez, Yolanda Upna; Zúñiga Ripa, Amaia; Barquero-Calvo, Elías; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Arce Gorvel, Vilma; Gorvel, Jean-Pierre; Moreno, Edgardo; Miguel, María Jesús de; Grilló Dolset, María Jesús; Moriyón Uría, Ignacio; Iriarte, Maite (Public Library of Science, 2011)   Artículo / Artikulua  OpenAccess
      The brucellae are alpha-Proteobacteria facultative intracellular parasites that cause an important zoonosis. These bacteria escape early detection by innate immunity, an ability associated to the absence of marked ...
    • Brucellosis vaccines: assessment of brucella melitensis lipopolysaccharide rough mutants defective in core and O-polysaccharide synthesis and export 

      González, David; Grilló Dolset, María Jesús; Miguel, María Jesús de; Ali, Tara; Arce Gorvel, Vilma; Delrue, Rose May; Conde Álvarez, Raquel; Muñoz Álvaro, Pilar María; López Goñi, Ignacio; Iriarte, Maite; Marín, Clara M.; Weintraub, Andrej; Widmalm, Goeran; Zygmunt, Michel; Letesson, Jean-Jacques; Gorvel, Jean-Pierre; Blasco, José María Upna; Moriyón Uría, Ignacio (Public Library of Science, 2008)   Artículo / Artikulua  OpenAccess
      Background: The brucellae are facultative intracellular bacteria that cause brucellosis, one of the major neglected zoonoses. In endemic areas, vaccination is the only effective way to control this disease. Brucella ...
    • BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence 

      Manterola, Lorea; Guzman-Verri, Caterina; Chaves Olarte, Esteban; Barquero-Calvo, Elías; Miguel, María Jesús de; Moriyon, Ignacio; Grilló Dolset, María Jesús; López Goñi, Ignacio; Moreno, Edgardo (American Society for Microbiology, 2007)   Artículo / Artikulua  OpenAccess
      The Brucella abortus two-component regulatory system BvrR/BvrS controls the expression of outer membrane proteins (Omp) Omp3a (Omp25) and Omp3b (Omp22). Disruption of bvrS or bvrR generates avirulent mutants with altered ...
    • Calcium inhibits bap-dependent multicellular behavior in Staphylococcus aureus 

      Arrizubieta, M. J.; Toledo Arana, Alejandro Upna; Amorena Zabalza, Beatriz Upna; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2004)   Artículo / Artikulua  OpenAccess
      Bap (biofilm-associated protein) is a 254-kDa staphylococcal surface protein implicated in formation of biofilms by staphylococci isolated from chronic mastitis infections. The presence of potential EF-hand motifs in the ...
    • Characterization of nontypable haemophilus influenzae isolates recovered from adult patients with underlying chronic lung disease reveals genotypic and phenotypic traits associated with persistent infection 

      Garmendia, Junkal; Viadas Martínez, Cristina Upna; Calatayud, Laura; Mell, Joshua Chang; Martí Lliteras, Pau; Euba, Begoña; Llobet, Enrique; Gil Puig, Carmen Upna; Bengoechea Alonso, José Antonio; Redfield, Rosemary J.; Liñares, Josefina (Public Library of Science, 2014)   Artículo / Artikulua  OpenAccess
      Nontypable Haemophilus influenzae (NTHi) has emerged as an important opportunistic pathogen causing infection in adults suffering obstructive lung diseases. Existing evidence associates chronic infection by NTHi to the ...