The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training
Fecha
2013Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Impacto
|
10.1186/1471-2318-13-131
Resumen
Background: We studied the influence of the ACE I/D and ACTN3 R577X polymorphisms (single or combined) on
lower-extremity function in older women in response to high-speed power training.
Methods: One hundred and thirty-nine healthy older Caucasian women participated in this study (age: 65.5 ± 8.2 years,
body mass: 67.0 ± 10.0 kg and height: 1.57 ± 0.06 m). Walking speed (S10) performance and fun ...
[++]
Background: We studied the influence of the ACE I/D and ACTN3 R577X polymorphisms (single or combined) on
lower-extremity function in older women in response to high-speed power training.
Methods: One hundred and thirty-nine healthy older Caucasian women participated in this study (age: 65.5 ± 8.2 years,
body mass: 67.0 ± 10.0 kg and height: 1.57 ± 0.06 m). Walking speed (S10) performance and functional capacity
assessed by the “get-up and go” (GUG) mobility test were measured at baseline (T1) and after a consecutive 12-week
period of high-speed power training (40-75% of one repetition maximum in arm and leg extensor exercises; 3 sets
4–12 reps, and two power exercises for upper and lower extremity). Genomic DNA was extracted from blood samples,
and genotyping analyses were performed by PCR methods. Genotype distributions between groups were compared
by Chi-Square test and the gains in physical performance were analyzed by two-way, repeated-measures ANOVA.
Results: There were no significant differences between genotype groups in men or women for adjusted baseline
phenotypes (P > 0.05). ACE I/D and ACTN3 polymorphisms showed a significant interaction genotype-training only in
S10 (P = 0.012 and P = 0.044, respectively) and not in the GUG test (P = 0.311 and P = 0.477, respectively). Analyses of
the combined effects between genotypes showed no other significant differences in all phenotypes (P < 0.05) at
baseline. However, in response to high-speed power training, a significant interaction on walking speed (P = 0.048)
was observed between the “power” (ACTN3 RR + RX & ACE DD) versus “non-power” muscularity-oriented genotypes
(ACTN3 XX & ACE II + ID)].
Conclusions: Thus, ACE I/D and ACTN3 R577X polymorphisms are likely candidates in the modulation of
exercise-related gait speed phenotype in older women but not a significant influence in mobility traits. [--]
Materias
Resistance training,
Angiotensin converting-enzyme,
Alpha-Actinin-3,
Women,
Lower mobility
Editor
BioMed Central
Publicado en
BMC Geriatrics 2013 13:131
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila
Versión del editor
Entidades Financiadoras
The study was developed with the aid of a research fellowship, reference
number SFRH/BD/47114/2008, funded by POPH – QREN, shared by the
European Social Fund and the national funds of MCTES. This work was
supported in part by the Spanish Department of Health and Institute Carlos
III of the Government of Spain [Spanish Net on Aging and frailty; (RETICEF)]
and Economy and Competitivity Department of the Government of Spain,
under grants numbered RD12/043/0002, and DEP2011-24105, respectively.
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La licencia del ítem se describe como © 2013 Pereira et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.