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Human papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samples
dc.creator | Muñoz, Marina | es_ES |
dc.creator | Camargo, Milena | es_ES |
dc.creator | Soto de León, Sara | es_ES |
dc.creator | Sánchez, Ricardo | es_ES |
dc.creator | Parra, Diana | es_ES |
dc.creator | Pineda Peña, Andrea | es_ES |
dc.creator | Sussmann, Otto | es_ES |
dc.creator | Pérez Prados, Antonio | es_ES |
dc.creator | Patarroyo, Manuel Elkin | es_ES |
dc.creator | Patarroyo, Manuel Alfonso | es_ES |
dc.date.accessioned | 2017-02-10T09:41:41Z | |
dc.date.available | 2017-02-10T09:41:41Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1932-6203 (Electronic) | |
dc.identifier.uri | https://hdl.handle.net/2454/23537 | |
dc.description.abstract | Infection, coinfection and type-specific human papillomavirus (HPV) distribution was evaluated in human immunodeficiency virus (HIV)-positive women from paired cervical and urine samples. Paired cervical and urine samples (n = 204) were taken from HIV-positive women for identifying HPV-DNA presence by using polymerase chain reaction (PCR) with three generic primer sets (GP5+/6+, MY09/11 and pU1M/2R). HPV-positive samples were typed for six high-risk HPV (HR-HPV) (HPV-16, -18, -31, -33, -45 and -58) and two low-risk (LR-HPV) (HPV-6/11) types. Agreement between paired sample results and diagnostic performance was evaluated. HPV infection prevalence was 70.6% in cervical and 63.2% in urine samples. HPV-16 was the most prevalent HPV type in both types of sample (66.7% in cervical samples and 62.0% in urine) followed by HPV-31(47.2%) in cervical samples and HPV-58 (35.7%) in urine samples. There was 55.4% coinfection (infection by more than one type of HPV) in cervical samples and 40.2% in urine samples. Abnormal Papanicolau smears were observed in 25.3% of the women, presenting significant association with HPV-DNA being identified in urine samples. There was poor agreement of cervical and urine sample results in generic and type-specific detection of HPV. Urine samples provided the best diagnosis when taking cytological findings as reference. In conclusion including urine samples could be a good strategy for ensuring adherence to screening programs aimed at reducing the impact of cervical cancer, since this sample is easy to obtain and showed good diagnostic performance. | en |
dc.description.sponsorship | This project was funded by the Basque Cooperation Agency Development and by the Spanish Agency for International Development Cooperation (AECID). | en |
dc.format.extent | 7 p. | |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Public Library of Science | en |
dc.relation.ispartof | PLoS ONE 8(2): e56509 | en |
dc.rights | © 2013 Muñoz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/ | |
dc.subject | Human papillomavirus (HPV) | en |
dc.subject | HIV | en |
dc.subject | Urine samples | en |
dc.subject | Cervical samples | en |
dc.title | Human papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samples | en |
dc.type | Artículo / Artikulua | es |
dc.type | info:eu-repo/semantics/article | en |
dc.contributor.department | Estadística e Investigación Operativa | es_ES |
dc.contributor.department | Estatistika eta Ikerketa Operatiboa | eu |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.identifier.doi | 10.1371/journal.pone.0056509 | |
dc.relation.publisherversion | https://dx.doi.org/10.1371/journal.pone.0056509 | |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |