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dc.creatorDaba, A.es_ES
dc.creatorEl Demellawy, M.es_ES
dc.creatorEl Eshasy, H.es_ES
dc.date.accessioned2018-02-14T09:31:28Z
dc.date.available2018-02-14T09:31:28Z
dc.date.issued2006
dc.identifier.isbn84-9769-107-5
dc.identifier.urihttps://hdl.handle.net/2454/27209
dc.descriptionComunicación presentada al VI Meeting on Genetics and Cellular Biology of Basidiomycetes (GCBB-VI), organizado por y celebrado en la Universidad Pública de Navarra el 3-6 de junio de 2005.es_ES
dc.description.abstractIt has been known for many years that some compounds produced by edible mushrooms encompass anticancer activities. Most of production methods were based on cultivation of mushroom in solid medium. In the present study Pleurotus ostreatus mycelia were grown in submerged culture. The cultivation of fungal cells in submerged culture resulted in higher growth rate with better control of production process. The bioactive polysaccharides (both intracellular and extracellular) were extracted from culture by solvent repeated precipitation. The polysaccharide structure was determined by examining NMR, IR spectra and the primary structure of the polysaccharide was mainly glucan. The 13C NMR spectral pattern indicated the polysaccharides are highly branched with mainly 1→3 and 1→6 linkage. The results of in vitro anti cancer studies demonstrate that this type of polysaccharides possesses anticancer activity against human oesophageal cancer cell line. Moreover, in the course of in vitro studies, mushroom polysaccharides showed anti-tumour activity and also considered to be biological response modifier because of their mechanism of action through stimulation of the immune system. The polysaccharide activity is especially beneficial in clinics when used as an adjuvant with chemotherapy to decrease its side effect. This work describes production process of anti cancer compound( s) by mushrooms and suitable for pharmaceutical industries.en
dc.format.extent13 p.
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoaes
dc.relation.ispartofAntonio G. Pisabarro and Lucía Ramírez (eds.): VI Meeting on Genetics and Cellular Biology of Basidiomycetes (GCBB-VI). Pamplona: Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa, 2006.es
dc.rights© Autores; Universidad Pública de Navarra. Esta publicación no puede ser reproducida, almacenada o transmitida total o parcialmente, sea cual fuere el medio y el procedimiento, incluidas las fotocopias, sin permiso previo concedido por escrito por los titulares del copyright.es_ES
dc.subjectPleorotus ostreatusen
dc.subjectAnticancer activityen
dc.subjectSubmerged cultureen
dc.subjectExtracellular polysaccharides (EPS)en
dc.titleAnticancer activity of polysaccharides produced by Pleurotus ostreatus in submerged cultureen
dc.typeinfo:eu-repo/semantics/conferenceObjecten
dc.typeContribución a congreso / Biltzarrerako ekarpenaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes


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