The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis
Fecha
2016Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Impacto
|
10.1186/s12885-016-2733-z
Resumen
Background: Insulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation,
differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancerrelated
outcomes and survival, although its effects on IGF´s are not well understood. This meta-analysis aimed
to determine the effects of exercise in modulating IGF´s system in ...
[++]
Background: Insulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation,
differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancerrelated
outcomes and survival, although its effects on IGF´s are not well understood. This meta-analysis aimed
to determine the effects of exercise in modulating IGF´s system in breast cancer survivors.
Methods: Databases of PuMed, EMBASE, Cochrane Central Register of Controlled Trials, EMBASE, ClinicalTrials.
gov, SPORTDiscus, LILACS and Scopus were systematically searched up to November 2014. Effect estimates were
calculated through a random-effects model of meta-analysis according to the DerSimonian and Laird method.
Heterogeneity was evaluated with the I2 test. Risk of bias and methodological quality were evaluated using the
PEDro score.
Results: Five randomized controlled trials (n = 235) were included. Most women were post-menopausal. Highquality
and low risk of bias were found (mean PEDro score = 6.2 ± 1). Exercise resulted in significant improvements
on IGF-I, IGF-II, IGFBP-I, IGFBP-3, Insulin and Insulin resistance (P < 0.05). Non-significant differences were found for
Glucose. Aerobic exercise improved IGF-I, IGFBP-3 and Insulin. No evidence of publication bias was detected by
Egger´s test (p = 0.12).
Conclusions: Exercise improved IGF´s in breast cancer survivors. These findings provide novel insight regarding the
molecular effects of exercise on tumoral microenvironment, apoptosis and survival in breast cancer survivors. [--]
Materias
Breast cancer,
Exercise,
Insulin-like growth factor,
Binding proteins,
Tumor microenvironment
Editor
BioMed Central
Publicado en
BMC Cancer (2016) 16:682
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila
Versión del editor
Entidades Financiadoras
The authors would like to acknowledge Universidad Santo Tomás, Bogotá
for the financial support to the GICAEDS Group (Project: Práctica del
autoexamen de seno y los conocimientos, factores de riesgo y estilos de
vida relacionados al cáncer de mama en mujeres jóvenes de la USTA
FODEIN, Number: 4110060001-008).
Aparece en las colecciones
Los documentos de Academica-e están protegidos por derechos de autor con todos los derechos reservados, a no ser que se indique lo contrario.
La licencia del ítem se describe como © 2016 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0
International License, which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.