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The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis
dc.creator | Meneses Echávez, José Francisco | es_ES |
dc.creator | González Jiménez, Emilio | es_ES |
dc.creator | Schmidt Río-Valle, Jacqueline | es_ES |
dc.creator | Correa Bautista, Jorge Enrique | es_ES |
dc.creator | Izquierdo Redín, Mikel | es_ES |
dc.creator | Ramírez Vélez, Robinson | es_ES |
dc.date.accessioned | 2018-08-31T08:07:58Z | |
dc.date.available | 2018-08-31T08:07:58Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1471-2407 | |
dc.identifier.uri | https://hdl.handle.net/2454/30351 | |
dc.description.abstract | Background: Insulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancerrelated outcomes and survival, although its effects on IGF´s are not well understood. This meta-analysis aimed to determine the effects of exercise in modulating IGF´s system in breast cancer survivors. Methods: Databases of PuMed, EMBASE, Cochrane Central Register of Controlled Trials, EMBASE, ClinicalTrials. gov, SPORTDiscus, LILACS and Scopus were systematically searched up to November 2014. Effect estimates were calculated through a random-effects model of meta-analysis according to the DerSimonian and Laird method. Heterogeneity was evaluated with the I2 test. Risk of bias and methodological quality were evaluated using the PEDro score. Results: Five randomized controlled trials (n = 235) were included. Most women were post-menopausal. Highquality and low risk of bias were found (mean PEDro score = 6.2 ± 1). Exercise resulted in significant improvements on IGF-I, IGF-II, IGFBP-I, IGFBP-3, Insulin and Insulin resistance (P < 0.05). Non-significant differences were found for Glucose. Aerobic exercise improved IGF-I, IGFBP-3 and Insulin. No evidence of publication bias was detected by Egger´s test (p = 0.12). Conclusions: Exercise improved IGF´s in breast cancer survivors. These findings provide novel insight regarding the molecular effects of exercise on tumoral microenvironment, apoptosis and survival in breast cancer survivors. | en |
dc.description.sponsorship | The authors would like to acknowledge Universidad Santo Tomás, Bogotá for the financial support to the GICAEDS Group (Project: Práctica del autoexamen de seno y los conocimientos, factores de riesgo y estilos de vida relacionados al cáncer de mama en mujeres jóvenes de la USTA FODEIN, Number: 4110060001-008). | en |
dc.format.extent | 10 p. | |
dc.format.mimetype | application/pdf | en |
dc.format.mimetype | application/zip | en |
dc.language.iso | eng | en |
dc.publisher | BioMed Central | en |
dc.relation.ispartof | BMC Cancer (2016) 16:682 | en |
dc.rights | © 2016 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Breast cancer | en |
dc.subject | Exercise | en |
dc.subject | Insulin-like growth factor | en |
dc.subject | Binding proteins | en |
dc.subject | Tumor microenvironment | en |
dc.title | The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | Artículo / Artikulua | es |
dc.contributor.department | Ciencias de la Salud | es_ES |
dc.contributor.department | Osasun Zientziak | eu |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.identifier.doi | 10.1186/s12885-016-2733-z | |
dc.relation.publisherversion | https://doi.org/10.1186/s12885-016-2733-z | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
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the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.