Mostrar el registro sencillo del ítem

dc.creatorCrespo, Helenaes_ES
dc.creatorGuillén, Hugoes_ES
dc.creatorPablo Maiso, Lorena dees_ES
dc.creatorGómez Arrebola, Carmenes_ES
dc.creatorRodríguez, Gregorioes_ES
dc.creatorGlaría Ezquer, Idoiaes_ES
dc.creatorAndrés Cara, Damián dees_ES
dc.creatorReina Arias, Ramséses_ES
dc.date.accessioned2018-09-04T06:43:45Z
dc.date.available2018-09-04T06:43:45Z
dc.date.issued2017
dc.identifier.issn1654-6628 (Print)
dc.identifier.issn1654-661X (Electronic)
dc.identifier.urihttps://hdl.handle.net/2454/30426
dc.description.abstractβ-glucans exhibited in cell walls of several pathogens as bacteria or fungi are sensed by pathogen recognition receptors such as scavenger receptors present in antigen presenting cells, i.e., macrophages. β-glucans obtained from Shiitake mushrooms were chemically characterized. A β-glucan supplemented diet was assayed for 30 days in rabbits aiming to characterize the immune response elicited in blood-derived macrophages. M1 and M2 profiles of macrophage differentiation were confirmed in rabbits by in vitro stimulation with IFN-γ and IL-4 and marker quantification of each differentiation pathway. Blood derived macrophages from rabbits administered in vivo with the β-glucan supplemented diet showed higher IL-4, IFN-γ and RAGE together with lower IL-10 relative expression, indicative of an ongoing immune response. Differences in IL-1β, IL-13 and IL-4 expression were also found in rabbit sera by ELISA suggesting further stimulation of the adaptive response. Recent challenges in the rabbit industry include the search of diet supplements able to elicit an immune stimulation with particular interest in facing pathogens such as viruses or bacteria. β–glucans from fungi may contribute to maintain an immune steady state favouring protection and thus reducing antibiotic treatment.en
dc.description.sponsorshipThis work was funded by MAGRAMA, IDi 2014 (REF.: 20140020001815), CDTI (Ref.: IDI 20140852) and ADER (Ref.: 2013-l-lDD-00074). Ramsés Reina was supported by Spanish Ministry of Science and Innovation ‘Ramón y Cajal’ contract.en
dc.format.extent8 p.
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherTaylor & Francisen
dc.relation.ispartofFood & Nutrition Research, 2017 Vol. 61, 1412791en
dc.rights© 2017 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectFungal β-glucanen
dc.subjectMacrophagesen
dc.subjectPolarizationen
dc.subjectRabbiten
dc.subjectDieten
dc.titleLentinula edodes β-glucan enriched diet induces pro- and anti-inflammatory macrophages in rabbiten
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentUniversidad Pública de Navarra. Instituto de Agrobiotecnologíaes_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Agrobioteknologiako Institutuaeu
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.1080/16546628.2017.1412791
dc.relation.publisherversionhttps://doi.org/10.1080/16546628.2017.1412791
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

© 2017 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
La licencia del ítem se describe como © 2017 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.