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dc.creatorAriza Gracia, Miguel A.es_ES
dc.creatorZurita Gabasa, Jesúses_ES
dc.creatorPiñero, David P.es_ES
dc.creatorRodríguez Matas, José F.es_ES
dc.creatorCalvo, Begoñaes_ES
dc.date.accessioned2018-09-06T12:20:17Z
dc.date.available2018-09-06T12:20:17Z
dc.date.issued2015
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/2454/30540
dc.description.abstractThe mechanical response of the cornea subjected to a non-contact air-jet tonometry diagnostic test represents an interplay between its geometry, the corneal material behavior and the loading. The objective is to study this interplay to better understand and interpret the results obtained with a non-contact tonometry test. A patient-specific finite element model of a healthy eye, accounting for the load free configuration, was used. The corneal tissue was modeled as an anisotropic hyperelastic material with two preferential directions. Three different sets of parameters within the human experimental range obtained from inflation tests were considered. The influence of the IOP was studied by considering four pressure levels (10–28 mmHg) whereas the influence of corneal thickness was studied by inducing a uniform variation (300–600 microns). A Computer Fluid Dynamics (CFD) air-jet simulation determined pressure loading exerted on the anterior corneal surface. The maximum apex displacement showed a linear variation with IOP for all materials examined. On the contrary, the maximum apex displacement followed a cubic relation with corneal thickness. In addition, a significant sensitivity of the apical displacement to the corneal stiffness was also obtained. Explanation to this behavior was found in the fact that the cornea experiences bending when subjected to an air-puff loading, causing the anterior surface to work in compression whereas the posterior surface works in tension. Hence, collagen fibers located at the anterior surface do not contribute to load bearing. Non-contact tonometry devices give useful information that could be misleading since the corneal deformation is the result of the interaction between the mechanical properties, IOP, and geometry. Therefore, a noncontact tonometry test is not sufficient to evaluate their individual contribution and a complete in-vivo characterization would require more than one test to independently determine the membrane and bending corneal behavior.en
dc.description.sponsorshipThe research leading these results has received funding from the European Union’s Seven Framework Program managed by REA Research Executive agency under Grant Agreement n° FP7-SME-2013 606634 and the Spanish Ministry of Economy and Competitiveness (DPI2011-27939-C02-01).en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherPublic Library of Scienceen
dc.relation.ispartofPlos One, 10(3): e0121486en
dc.rights© 2015 Ariza-Gracia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCorneaen
dc.subjectNon-contact tonometryen
dc.titleCoupled biomechanical response of the cornea assessed by non-contact tonometry. A simulation studyen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentUniversidad Pública de Navarra. Departamento de Ingeniería Mecánica, Energética y de Materialeses_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Mekanika, Energetika eta Materialen Ingeniaritza Sailaeu
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.1371/journal.pone.0121486
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/606634en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/6PN/DPI2011-27939en
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0121486
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes


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© 2015 Ariza-Gracia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as © 2015 Ariza-Gracia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.