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dc.creatorDelgado González, José Carloses_ES
dc.creatorMansilla Legorburo, Franciscoes_ES
dc.creatorFlorensa Vila, Josées_ES
dc.creatorInsausti Serrano, Ana Maríaes_ES
dc.creatorViñuela, Antonioes_ES
dc.creatorTuñón Álvarez, Teresaes_ES
dc.creatorCruz, Marcoses_ES
dc.creatorMohedano Moriano, Aliciaes_ES
dc.creatorInsausti, Ricardoes_ES
dc.creatorArtacho Pérula, Emilioes_ES
dc.date.accessioned2018-09-06T12:20:21Z
dc.date.available2018-09-06T12:20:21Z
dc.date.issued2015
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/2454/30550
dc.description.abstractThe decrease of volume estimates in different structures of the medial temporal lobe related to memory correlate with the decline of cognitive functions in neurodegenerative diseases. This study presents data on the association between MRI quantitative parameters of medial temporal lobe structures and their quantitative estimate in microscopic examination. Twelve control cases had ex-vivo MRI, and thereafter, the temporal lobe of both hemispheres was sectioned from the pole as far as the level of the splenium of the corpus callosum. Nissl stain was used to establish anatomical boundaries between structures in the medial temporal lobe. The study included morphometrical and stereological estimates of the amygdaloid complex, hippocampus, and temporal horn of the lateral ventricle, as well as different regions of grey and white matter in the temporal lobe. Data showed a close association between morphometric MRI images values and those based on the histological determination of boundaries. Only values in perimeter and circularity of the piamater were different. This correspondence is also revealed by the stereological study, although irregular compartments resulted in a lesser agreement. Neither age (< 65 yr and > 65yr) nor hemisphere had any effect. Our results indicate that ex-vivo MRI is highly associated with quantitative information gathered by histological examination, and these data could be used as structural MRI biomarker in neurodegenerative diseases.en
dc.description.sponsorshipThis study was funded by the Spanish Ministry of Science and Innovation I+D+i Project BFU-2009-14705 (EAP and RI), the Education, Culture and Sports of Castilla-La Mancha Autonomic Government Project PPII-2014-013-A (EAP and RI), and from the Health Research Foundation of Castilla- La Mancha (FISCAM) Project PI-2007-59.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherPublic Library of Scienceen
dc.relation.ispartofPlos One, 10(6):e0130314.en
dc.rights© 2015 Delgado-González et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectEx-vivo MRIen
dc.subjectMedial temporal lobe structuresen
dc.subjectHistological preparationsen
dc.titleQuantitative measurements in the human hippocampus and related areas: correspondence between ex-vivo MRI and histological preparationsen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentUniversidad Pública de Navarra. Departamento de Ciencias de la Saludes_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Osasun Zientziak Sailaeu
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.1371/journal.pone.0130314
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0130314
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes


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© 2015 Delgado-González et al. This is
an open access article distributed under the terms of
the Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
Except where otherwise noted, this item's license is described as © 2015 Delgado-González et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.