Now showing items 1-13 of 13

    • Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment 

      Celay Leoz, Ion Upna; Blanco Luquin, Idoia; Lázcoz, Paula Upna; Rotinen Díaz, Mirja Sofia Upna; Castresana, Javier S.; Encío Martínez, Ignacio Upna (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers ...
    • A diphenyldiselenide derivative induces autophagy via JNK in HTB-54 lung cancer cells 

      Díaz, Marta; González, Roncesvalles; Plano, Daniel; Palop, Juan Antonio; Sanmartín, Carmen; Encío Martínez, Ignacio Upna (Wiley, 2017)   Artículo / Artikulua  OpenAccess
      Symmetric aromatic diselenides are potential anticancer agents with strong cytotoxic activity. In this study, the in vitro anticancer activities of a novel series of diarylseleno derivatives from the diphenyldiselenide ...
    • Efecto de los probióticos Bifidobacterium y Lactobacilus gasseri sobre las acciones de la quercetina en cultivos celulares de cáncer de colon 

      Alfaro Larraya, María Upna (2014)   Tesis doctoral / Doktoretza tesia  OpenAccess
      La alimentación y la nutrición, junto con la actividad física, se encuentran entre los factores más determinantes para el desarrollo de enfermedades como el cáncer colorrectal,92 que en un 90% de los casos está asociado ...
    • A fermented food product containing lactic acid bacteria protects ZDF rats from the development of type 2 diabetes 

      Cabello Olmo, Miriam; Oneca, María; Torre Hernández, Paloma; Sainz, Neira; Moreno Aliaga, María J.; Guruceaga, Elizabeth; Díaz, Jesús Vicente; Encío Martínez, Ignacio Upna; Barajas Vélez, Miguel Ángel Upna; Araña Ciordia, Miriam Upna (MDPI, 2019)   Artículo / Artikulua  OpenAccess
      Type 2 diabetes (T2D) is a complex metabolic disease, which involves a maintained hyperglycemia due to the development of an insulin resistance process. Among multiple risk factors, host intestinal microbiota has received ...
    • Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma 

      Lázcoz, Paula Upna; Muñoz, Jorge; Nistal, Manuel; Pestaña, Ángel; Encío Martínez, Ignacio Upna; Sáez Castresana, Javier (BioMed Central, 2006)   Artículo / Artikulua  OpenAccess
      Background: Epigenetic alterations and loss of heterozygosity are mechanisms of tumor suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has recently been documented. RASSF1A, on 3p21.3, ...
    • Influence of storage temperature and packaging on bacteria and yeast viability in a plant-based fermented food 

      Cabello Olmo, Miriam; Oneca, María; Torre Hernández, Paloma; Díaz, Jesús Vicente; Encío Martínez, Ignacio Upna; Barajas Vélez, Miguel Ángel Upna; Araña Ciordia, Miriam Upna (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Optimization of food storage has become a central issue for food science and biotechnology, especially in the field of functional foods. The aim of this work was to investigate the influence of different storage strategies ...
    • Morphological and biochemical characterization of a cell death process induced by E3, a new synthetic diarylsulfonilurea analogue 

      Alonso Roldán, Marta Upna; Miglaccio, M.; Encío Martínez, Ignacio Upna; Asumendi, A.; Martínez Merino, Víctor Upna; Hilario, E.; García, M. (Hindawi, 2001)   Otro / Bestelakoa  OpenAccess
      With a view to finding new compounds with improved antitumoral activity and reduced secondary effects, our group, using theoretical structure-activity studies, has designed several analogues and derivatives of ...
    • Novel methylselenoesters as antiproliferative agents 

      Díaz Argelich, Nuria; Encío Martínez, Ignacio Upna; Plano, Daniel; Fernandes, Aristi P.; Palop, Juan Antonio; Sanmartín, Carmen (MDPI, 2017)   Artículo / Artikulua  OpenAccess
      Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the biological effects of Se compounds are exerted by their metabolites, with methylselenol (CH3SeH) being one of the key executors. In this ...
    • Novel N,N′-disubstituted acylselenoureas as potential antioxidant and cytotoxic agents 

      Ruberte, Ana Carolina; Ramos Inza, Sandra; Aydillo, Carlos; Talavera, Irene; Encío Martínez, Ignacio Upna; Plano, Daniel; Sanmartín, Carmen (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Selenium compounds are pivotal in medicinal chemistry for their antitumoral and antioxidant properties. Forty seven acylselenoureas have been designed and synthesized following a fragment-based approach. Different scaffolds, ...
    • Novel selenadiazole derivatives as selective antitumor and radical scavenging agents 

      Ruberte, Ana Carolina; Plano, Daniel; Encío Martínez, Ignacio Upna; Aydillo, Carlos; Sharma, Arun K.; Sanmartín, Carmen (Elsevier, 2018)   Artículo / Artikulua  OpenAccess
      Twenty-seven novel benzo[c][1,2,5]selenadiazole-5-carboxylic acid (BSCA) derivatives were designed and synthesized. Anti-proliferative activity of these structures was tested in vitro against a panel of five human cancer ...
    • Organoseleno cytostatic derivatives: autophagic cell death with AMPK and JNK activation 

      Garnica, Pablo; Encío Martínez, Ignacio Upna; Plano, Daniel; Palop, Juan Antonio; Sanmartín, Carmen (Elsevier Masson SAS, 2019)   Artículo / Artikulua
      Selenocyanates and diselenides are potential antitumor agents. Here we report two series of selenium derivatives related to selenocyanates and diselenides containing carboxylic, amide and imide moieties. These compounds ...
    • Synthesis and pharmacological screening of several aroyl and heteroaroyl selenylacetic acid derivatives as cytotoxic and antiproliferative agents 

      Sanmartín, Carmen; Plano, Daniel; Domínguez, Enrique; Font, María; Calvo, Alfonso; Prior, Celia; Encío Martínez, Ignacio Upna; Palop, Juan Antonio (MDPI, 2009)   Artículo / Artikulua  OpenAccess
      The synthesis and cytotoxic activity of a series of twenty six aroyl and heteroaroyl selenylacetic acid derivatives of general formula Ar-CO-Se-CH(2)-COOH or Heterar-CO-Se-CH(2)-COOH are reported. The synthesis was carried ...
    • Transcriptional regulation of type 11 17β-hydroxysteroid dehydrogenase expression in prostate cancer cells 

      Rotinen Díaz, Mirja Sofia Upna; Villar Bécares, Joaquín Upna; Celay Leoz, Ion Upna; Serrano Mendioroz, Irantzu Upna; Notario, Vicente; Encío Martínez, Ignacio Upna (Elsevier, 2011)   Artículo / Artikulua  OpenAccess
      Type 11 Hydroxysteroid (17-beta) dehydrogenase (HSD17B11) catalyzes the conversion of 5α-androstan-3α,17β-diol into androsterone suggesting that it may play an important role in androgen metabolism. We previously described ...