Now showing items 1-6 of 6

    • Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids 

      Matilla Cuenca, Leticia Upna Orcid; Gil Puig, Carmen Upna Orcid; Cuesta Ferre, Sergio; Rapún Araiz, Beatriz Upna Orcid; Mira, Alex; Lasa Uzcudun, Íñigo Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Ziemité, Miglé (Nature Research, 2020)   Artículo / Artikulua  OpenAccess
      The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the ...
    • Caracterización del sistema sensorial de dos componentes de Staphylococcus aureus 

      Rapún Araiz, Beatriz Upna Orcid (2020)   Tesis doctoral / Doktoretza tesia  OpenAccess
      En este trabajo de tesis hemos evaluado dos aproximaciones diferentes dedicadas a la búsqueda de fármacos que tengan como diana de acción los TCSs. Por un lado, dentro del proyecto 'Nuevas estrategias para el control de ...
    • The impact of two-component sensorial network in staphylococcal speciation 

      Rapún Araiz, Beatriz Upna Orcid; Haag, Andreas F.; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (Elsevier, 2020)   Artículo / Artikulua  OpenAccess
      Bacteria use two-component systems (TCSs) to sense and respond to their environments. Free-living bacteria usually contain dozens of TCSs, each of them responsible for sensing and responding to a different range of signals. ...
    • Inhibiting the two‑component system GraXRS with verteporfin to combat Staphylococcus aureus infections 

      Prieto Mariscal, Juana María; Rapún Araiz, Beatriz Upna Orcid; Gil Puig, Carmen Upna Orcid; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid; Latasa Osta, Cristina Upna (Nature Research, 2020)   Artículo / Artikulua  OpenAccess
      Infections caused by Staphylococcus aureus pose a serious and sometimes fatal health issue. With the aim of exploring a novel therapeutic approach, we chose GraXRS, a Two-Component System (TCS) that determines bacterial ...
    • Sensory deprivation in Staphylococcus aureus 

      Villanueva San Martín, Maite Upna Orcid; García Martínez, Begoña Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Rapún Araiz, Beatriz Upna Orcid; Ruiz de los Mozos Aliaga, Igor Upna; Solano Goñi, Cristina Upna Orcid; Martí, Miguel; Penadés, José R.; Toledo Arana, Alejandro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (Springer Nature, 2018)   Artículo / Artikulua  OpenAccess
      Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show ...
    • Systematic reconstruction of the complete two-component sensorial network in staphylococcus aureus 

      Rapún Araiz, Beatriz Upna Orcid; Haag, Andreas F.; Gil Puig, Carmen Upna Orcid; Dorado Morales, Pedro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2020)   Artículo / Artikulua  OpenAccess
      In bacteria, adaptation to changes in the environment is mainly controlled through two-component signal transduction systems (TCSs). Most bacteria contain dozens of TCSs, each of them responsible for sensing a different ...