Listar por tema "Staphylococcus aureus"
Mostrando ítems 21-40 de 51
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Genetic reductionist approach for studing the two-component signaling system in Staphylococcus aureus
Staphylococcus aureus es una bacteria ubicua capaz de colonizar una gran variedad de ambientes. En el hombre, S. aureus coloniza las fosas nasales, piel de las axilas, ingles, garganta o incluso el tracto intestinal. Se ... -
Genetic tools derived from Staphylococcus aureus for biotechnological applications in Gram-positive bacteria
Staphylococcus aureus is a versatile human pathogen that has emerged as one of the most successful infectious agents of recent times, able to cause a range of diseases including skin and soft tissue infections, endocarditis, ... -
The impact of two-component sensorial network in staphylococcal speciation
Bacteria use two-component systems (TCSs) to sense and respond to their environments. Free-living bacteria usually contain dozens of TCSs, each of them responsible for sensing and responding to a different range of signals. ... -
Inactivación de cepas de Staphylococcus aureus procedentes de infecciones asociadas a prótesis articulares, mediante la herramienta CRISPR/Cas9
Staphylococcus aureus es el agente causal más frecuente de infecciones asociadas a prótesis articulares. Cuando este se establece en la superficie de la prótesis formando biofilm, la matriz autosecretada favorece su ... -
Inhibiting the two‑component system GraXRS with verteporfin to combat Staphylococcus aureus infections
Infections caused by Staphylococcus aureus pose a serious and sometimes fatal health issue. With the aim of exploring a novel therapeutic approach, we chose GraXRS, a Two-Component System (TCS) that determines bacterial ... -
Killing niche competitors by remote-control bacteriophage induction
A surprising example of interspecies competition is the production by certain bacteria of hydrogen peroxide at concentrations that are lethal for others. A case in point is the displacement of Staphylococcus aureus by ... -
lnsights into bacterial functional amyloids using the staphyiococcal Bap protein asan amyloid model
(2022) Tesis doctoral / Doktoretza tesiaLos arniloides funcionales son componentes clave de la matriz del biofilrn de muchas bacterias. Estas estructuras proporcionan resistencia a las proteasas y a condiciones adversas de desnaturalización, y refuerzan y dan ... -
Near-infrared fluorescence imaging as an alternative to bioluminescent bacteria to monitor biomaterial-associated infections
Biomaterial-associated infection is one of the most common complications related with the implantation of any biomedical device. Several in vivo imaging platforms have emerged as powerful diagnostic tools to longitudinally ... -
Noncontiguous operon atlas in Staphylococcus aureus
(2023) Tesis doctoral / Doktoretza tesiaIn previous work from the group, we described the existence of a new transcriptional architecture that we call a noncontiguous operon (NcO). NcOs consist of groups of genes that are transcribed on the same RNA molecule, ... -
Novel strategies for treating biofilm and MRSA associated infections
En esta tesis hemos trabajado en dos estrategias, un cribado fenotípico y otro frente a una diana específica, que podrían ayudar a ampliar las alternativas terapéuticas frente a S. aureus. En el primer capítulo, nos hemos ... -
Operones no-contiguos: una nueva estrategia para coordinar la expresión de genes en bacterias
En esta tesis demostramos la existencia de un nivel superior de organización en la estructura del operón que denominamos operón no-contiguo y que consiste en un operón que contiene un gen o genes que se transcriben en la ... -
Papel de los sistemas de dos componentes de Staphylococcus aureus en la susceptibilidad a complestatina y corbomicina y en la regulación génica en ausencia de fosforilación
(2022) Tesis doctoral / Doktoretza tesiaStaphylococcus aureus es una bacteria versátil que se puede encontrar estableciendo una relación comensal en la piel de, aproximadamente, el 30% de la población sin causar ningún problema. Sin embargo, cuando ésta atraviesa ... -
Polymicrobial infections: do bacteria behave differently depending on their neighbours?
Despite the number of examples that correlate interspecies interactions in polymicrobial infections with variations in pathogenicity and antibiotic susceptibility of individual organisms, antibiotic therapies are selected ... -
Protein A-mediated multicellular behavior in Staphylococcus aureus
The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S. aureus cells ... -
Puesta a punto de un método de análisis de virulencia de Staphylococcus aureus en Caenorhabditis elegans
La forma clásica para analizar la virulencia de los microorganismos patógenos humanos ha sido el empleo de modelos animales mamíferos. Desde hace algún tiempo, se han desarrollado modelos alternativos no mamíferos, como ... -
Regulation of heterogenous lexA expression in staphylococcus aureus by an antisense RNA originating from transcriptional read-through upon natural mispairings in the sbrB intrinsic terminator
Bacterial genomes are pervasively transcribed, generating a wide variety of antisense RNAs (asRNAs). Many of them originate from transcriptional read-through events (TREs) during the transcription termination process. ... -
The regulon of the RNA chaperone CspA and its auto-regulation in Staphylococcus aureus
RNA-binding proteins (RBPs) are essential to finetune gene expression. RBPs containing the coldshock domain are RNA chaperones that have been extensively studied. However, the RNA targets and specific functions for ... -
Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections
Staphylococcus aureus can establish chronic infections on implanted medical devices due to its capacity to form biofilms. Analysis of the factors that assemble cells into a biofilm has revealed the occurrence of strains ... -
RinA controls phage-mediated packaging and transfer of virulence genes in gram-positive bacteria
Phage-mediated transfer of microbial genetic elements plays a crucial role in bacterial life style and evolution. In this study, we identify the RinA family of phage-encoded proteins as activators required for transcription ... -
The role of ArlRS and VraSR in regulating ceftaroline hypersusceptibility in methicillin-resistant Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus infections are a global health problem. New control strategies, including fifth-generation cephalosporins such as ceftaroline, have been developed, however rare sporadic resistance ...