Listar por autor "Montuenga, Luis M."

DSTYK inhibition increases the sensitivity of lung cancer cells to T cell-mediated cytotoxicity

Valencia, Karmele; Echepare, Mirari; Teijeira, Álvaro; Pasquier, Andrea; Bértolo, Cristina; Sáinz, Cristina; Tamayo Uria, Ibon; Picabea, Beñat; Bosco, Graziella; Thomas, Roman; Agorreta Arrazubi, Jackeline; López-Picazo, José María; Frigola, Joan; Amat, Ramón; Calvo, Alfonso; Felip, Enriqueta; Melero, Ignacio; Montuenga, Luis M. (Rockefeller University Press, 2022) Artículo / Artikulua

Lung cancer remains the leading cause of cancer-related death worldwide. We identify DSTYK, a dual serine/threonine and tyrosine non-receptor protein kinase, as a novel actionable target altered in non-small cell lung ...

Two cell line models to study multiorganic metastasis and immunotherapy in lung squamous cell carcinoma

Valencia, Karmele; Sainz, Cristina; Bertolo, Cristina; Biurrun, Gabriel de; Agorreta Arrazubi, Jackeline; Azpilikueta, Arantza; Larrayoz, Marta; Bosco, Graziella; Zandueta, Carolina; Redrado, Miriam; Redin, Esther; Expósito, Francisco; Serrano, Diego; Echepare, Mirari; Ajona, Daniel; Melero, Ignacio; Pío, Rubén; Thomas, Roman; Calvo, Alfonso; Montuenga, Luis M. (The Company of Biologists, 2022) Artículo / Artikulua

There is a paucity of adequate mouse models and cell lines available to study lung squamous cell carcinoma (LUSC). We have generated and characterized two models of phenotypically different transplantable LUSC cell lines, ...

Whole exome sequencing characterization of individuals presenting extreme phenotypes of high and low risk of developing tobacco-induced lung adenocarcinoma

Patiño García, Ana; Guruceaga, Elizabeth; Segura, Víctor; Sánchez Bayona, Rodrigo; Andueza, María Pilar; Tamayo Uria, Ibon; Serrano, Guillermo; Fusco, Juan Pablo; Pajares Villandiego, María Josefa

; Gúrpide, Alfonso; Ocón, Marimar; Sanmamed, Miguel F.; Rodríguez Ruiz, María; Melero, Ignacio; Lozano, María Dolores; Andrea, Carlos de; Pita, Guillermo; González Neira, Anna; González, Alvaro; Zulueta, Javier J.; Montuenga, Luis M.; Pío, Rubén; Pérez Gracia, José Luis (AME Publishing, 2021) Artículo / Artikulua

Background: tobacco is the main risk factor for developing lung cancer. Yet, some heavy smokers do not develop lung cancer at advanced ages while others develop it at young ages. Here, we assess for the first time the ...