Listar por tema "Biofilms"
Mostrando ítems 1-16 de 16
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Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids
Matilla Cuenca, Leticia
; Gil Puig, Carmen ; Cuesta Ferre, Sergio; Rapún Araiz, Beatriz ; Mira, Alex; Lasa Uzcudun, Íñigo ; Valle Turrillas, Jaione ; Ziemité, Miglé (Nature Research, 2020)
Artículo / Artikulua 
The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the ... -
Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection
Gil Puig, Carmen ; Solano Goñi, Cristina ; Burgui Erice, Saioa ; Latasa Osta, Cristina ; García Martínez, Begoña ; Toledo Arana, Alejandro ; Lasa Uzcudun, Íñigo ; Valle Turrillas, Jaione (American Society for Microbiology, 2014)
Artículo / Artikulua
The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ... -
Biofilm switch and immune response determinants at early stages of infection
Valle Turrillas, Jaione ; Solano Goñi, Cristina ; García Martínez, Begoña ; Toledo Arana, Alejandro ; Lasa Uzcudun, Íñigo (Elsevier (Cell Press), 2013)
Artículo / Artikulua
Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a ... -
The biofilm-associated surface protein Esp of Enterococcus faecalis forms amyloid-like fibers
Taglialegna, Agustina; Matilla Cuenca, Leticia ; Dorado Morales, Pedro ; Navarro, Susanna; Ventura, Salvador; Garnett, James A.; Lasa Uzcudun, Íñigo ; Valle Turrillas, Jaione (Nature ResearchNanyang Technological University (Singapur), 2020)
Artículo / Artikulua
Functional amyloids are considered as common building block structures of the biofilm matrix in different bacteria. In previous work, we have shown that the staphylococcal surface protein Bap, a member of the Biofilm-Associated ... -
Coordinated cyclic-di-GMP repression of salmonella motility through YcgR and cellulose
Zorraquino Salvo, Violeta; García Martínez, Begoña ; Latasa Osta, Cristina ; Echeverz Sarasúa, Maite ; Toledo Arana, Alejandro ; Valle Turrillas, Jaione ; Lasa Uzcudun, Íñigo ; Solano Goñi, Cristina (American Society for Microbiology, 2013)
Artículo / Artikulua
Cyclic di-GMP (c-di-GMP) is a secondary messenger that controls a variety of cellular processes, including the switch between a biofilm and a planktonic bacterial lifestyle. This nucleotide binds to cellular effectors in ... -
Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling
Valle Turrillas, Jaione ; Burgui Erice, Saioa ; Langheinrich, Denise; Gil Puig, Carmen ; Solano Goñi, Cristina ; Toledo Arana, Alejandro ; Helbig, Ralf; Lasagni, Andrés; Lasa Uzcudun, Íñigo (2015)
Artículo / Artikulua
Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial ... -
Expression of the biofilm-associated protein interferes with host protein receptors of Staphylococcus aureus and alters the infective process
Cucarella, Carme; Tormo Más, María Ángeles; Knecht, Erwin; Amorena Zabalza, Beatriz; Lasa Uzcudun, Íñigo ; Foster, Timothy J.; Penadés, José R. (American Society for Microbiology, 2002)
Artículo / Artikulua
The adherence of Staphylococcus aureus to soluble proteins and extracellular-matrix components of the host is one of the key steps in the pathogenesis of staphylococcal infections. S. aureus presents a family of adhesins ... -
Genetic tools derived from Staphylococcus aureus for biotechnological applications in Gram-positive bacteria
Dorado Morales, Pedro (2021)
Tesis doctoral / Doktoretza tesia
Staphylococcus aureus is a versatile human pathogen that has emerged as one of the most successful infectious agents of recent times, able to cause a range of diseases including skin and soft tissue infections, endocarditis, ... -
Global assessment of small RNAs reveals a non-coding transcript involved in biofilm formation and attachment in Acinetobacter baumannii ATCC 17978
Álvarez Fraga, Laura; Rumbo Feal, Soraya; Pérez, Astrid; Gómez, Manuel J.; Valle Turrillas, Jaione (Public Library of Science, 2017)
Artículo / Artikulua
Many strains of Acinetobacter baumannii have been described as being able to form biofilm. Small non-coding RNAs (sRNAs) control gene expression in many regulatory circuits in bacteria. The aim of the present work was to ... -
Inactivación de cepas de Staphylococcus aureus procedentes de infecciones asociadas a prótesis articulares, mediante la herramienta CRISPR/Cas9
(2020) Trabajo Fin de Máster/Master Amaierako Lana
Staphylococcus aureus es el agente causal más frecuente de infecciones asociadas a prótesis articulares. Cuando este se establece en la superficie de la prótesis formando biofilm, la matriz autosecretada favorece su ... -
lnsights into bacterial functional amyloids using the staphyiococcal Bap protein asan amyloid model
Matilla Cuenca, Leticia (2022)
Tesis doctoral / Doktoretza tesia
Los arniloides funcionales son componentes clave de la matriz del biofilrn de muchas bacterias. Estas estructuras proporcionan resistencia a las proteasas y a condiciones adversas de desnaturalización, y refuerzan y dan ... -
Novel strategies for treating biofilm and MRSA associated infections
(2021) Tesis doctoral / Doktoretza tesia
En esta tesis hemos trabajado en dos estrategias, un cribado fenotípico y otro frente a una diana específica, que podrían ayudar a ampliar las alternativas terapéuticas frente a S. aureus. En el primer capítulo, nos hemos ... -
Producción recombinante de dominios amiloides para su caracterización biofísica y análisis de su efecto sobre el plegamiento de amiloides humanos
(2022) Trabajo Fin de Grado/Gradu Amaierako LanaEstudios recientes han introducido un cambio de paradigma en el reconocimiento de los amiloides bacterianos como elementos funcionales y estructurales del biofilm. El biofilm formado por la microbiota del tracto intestinal ... -
Protein A-mediated multicellular behavior in Staphylococcus aureus
Merino, Nekane; Toledo Arana, Alejandro ; Vergara Irigaray, Marta ; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Calvo, Enrique; Lopez, Juan Antonio; Foster, Timothy J.; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2008)
Artículo / Artikulua
The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S. aureus cells ... -
Role of biofilm-associated protein bap in the pathogenesis of bovine Staphylococcus aureus
Cucarella, Carme; Tormo Más, María Ángeles; Ubeda, Carles; Trotonda, María Pilar; Monzon, Marta; Peris, Cristòfol; Amorena Zabalza, Beatriz; Lasa Uzcudun, Íñigo ; Penadés, José R. (American Society for Microbiology, 2004)
Artículo / Artikulua
Staphylococcus aureus is a common cause of intramammary infections, which frequently become chronic, associated with the ability of the bacteria to produce biofilm. Here, we report a relationship between the ability to ... -
Towards the identification of the common features of bacterial biofilm development
Lasa Uzcudun, Íñigo (Sociedad Española de Microbiología, 2006)
Artículo / Artikulua
Los microorganismos pueden vivir y proliferar como células individuales que nadan libremente en el medio o crecer en comunidades multicelulares muy bien organizadas dentro de una matriz que ellas mismas han sintetizado y ...
