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Inhibiting the two‑component system GraXRS with verteporfin to combat Staphylococcus aureus infections
(Nature Research, 2020)
Artículo / Artikulua,
Infections caused by Staphylococcus aureus pose a serious and sometimes fatal health issue. With the
aim of exploring a novel therapeutic approach, we chose GraXRS, a Two-Component System (TCS)
that determines bacterial ...
Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids
(Nature Research, 2020)
info:eu-repo/semantics/article,
The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the ...
Fitness cost evolution of natural plasmids of staphylococcus aureus
(American Society for Microbiology, 2021)
info:eu-repo/semantics/article,
Plasmids have largely contributed to the spread of antimicrobial resistance genes among Staphylococcus strains. Knowledge about the fitness cost that plasmids confer on clinical staphylococcal isolates and the coevolutionary ...
The role of ArlRS and VraSR in regulating ceftaroline hypersusceptibility in methicillin-resistant Staphylococcus aureus
(MDPI, 2021)
info:eu-repo/semantics/article,
Methicillin-resistant Staphylococcus aureus infections are a global health problem. New control strategies, including fifth-generation cephalosporins such as ceftaroline, have been developed, however rare sporadic resistance ...
Polymicrobial infections: do bacteria behave differently depending on their neighbours?
(Taylor & Francis, 2018)
info:eu-repo/semantics/other,
Despite the number of examples that correlate interspecies interactions in polymicrobial infections with variations in pathogenicity and antibiotic susceptibility of individual organisms, antibiotic therapies are selected ...
A systematic evaluation of the two-component systems network reveals that ArlRS is a key regulator of catheter colonization by Staphylococcus aureus
(Frontiers Media, 2018)
info:eu-repo/semantics/article,
Two-component systems (TCS) are modular signal transduction pathways that allow cells to adapt to prevailing environmental conditions by modifying cellular physiology. Staphylococcus aureus has 16 TCSs to adapt to the ...
Systematic reconstruction of the complete two-component sensorial network in staphylococcus aureus
(American Society for Microbiology, 2020)
info:eu-repo/semantics/article,
In bacteria, adaptation to changes in the environment is mainly controlled through two-component signal transduction systems (TCSs). Most bacteria contain dozens of TCSs, each of them responsible for sensing a different ...
The impact of two-component sensorial network in staphylococcal speciation
(Elsevier, 2020)
info:eu-repo/semantics/article,
Bacteria use two-component systems (TCSs) to sense and respond to their environments. Free-living bacteria usually contain dozens of TCSs, each of them responsible for sensing and responding to a different range of signals. ...