• Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα 

      Liang, Ning; Damdimopoulos, Anastasius; Goñi Irigoyen, Saioa Upna Orcid; Huang, Zhiqiang; Vedin, Lise-Lotte; Jakobsson, Tomas; Giudici, Marco; Ahmed, Osman; Pedrelli, Matteo; Barilla, Serena; Alzaid, Fawaz; Mendoza, Arturo; Schröder, Tarja; Kuiper, Raoul; Parini, Paolo; Hollenberg, Anthony; Lefebvre, Philippe; Francque, Sven; Van Gaal, Luc; Staels, Bart; Venteclef, Nicolas; Treuter, Eckardt; Fan, Rongrong (Nature Research, 2019)   Artículo / Artikulua  OpenAccess
      Obesity triggers the development of non-alcoholic fatty liver disease (NAFLD), which involves alterations of regulatory transcription networks and epigenomes in hepatocytes. Here we demonstrate that G protein pathway ...
    • Impaired LXRα phosphorylation attenuates progression of fatty liver disease 

      Bécares, Natalia; Gage, Matthew C.; Voisin, Maud; Shrestha, Elina; Martín-Gutiérrez, Lucía; Liang, Ning; Louie, Rikah; Pourcet, Benoît; Pello, Óscar M.; Luong, Tu Vinh; Goñi Irigoyen, Saioa Upna Orcid; Pichardo-Almarza, César; Røberg-Larsen, Hanne; Díaz-Zuccarini, Vanessa; Steffensen, Knut R.; O’Brien, Alastair; Garabedian, Michael J.; Rombouts, Krista; Treuter, Eckardt; Pineda-Torra, Inés (Cell Press, 2019)   Artículo / Artikulua  OpenAccess
      Non-alcoholic fatty liver disease (NAFLD) is a very common indication for liver transplantation. How fat-rich diets promote progression from fatty liver to more damaging inflammatory and fibrotic stages is poorly understood. ...

      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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