Listar Colecciones de Investigación y Producción Científica - Ikerketa eta ekoizpen zientifikoko Bildumak por autor UPNA "Acha Santamaría, Blanca"
Mostrando ítems 1-6 de 6
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Association of blood-based DNA methylation markers with late-onset alzheimer disease: a potential diagnostic approach
Background and Objectives: There is an urgent need to identify novel noninvasive biomarkers for Alzheimer disease (AD) diagnosis. Recent advances in blood-based measurements of phosphorylated tau (pTau) species are promising ... -
Gender-dependent deregulation of linear and circular RNA variants of homer1 in the entorhinal cortex of Alzheimer’s disease
The HOMER1 gene is involved in synaptic plasticity, learning and memory. Recent studies show that circular RNA derived from HOMER1 (circHOMER1) expression is altered in some Alzheimer’s disease (AD) brain regions. In ... -
Identificación de biomarcadores epigenéticos de metilación del DNA en la sangre periférica de pacientes con enfermedad de Alzheimer
(2024) Tesis doctoral / Doktoretza tesiaEn esta tesis doctoral, se investiga el papel de la metilación del DNA como un potencial biomarcador diagnóstico de la EA, dada la novedad que los mecanismos epigenéticos han supuesto en la búsqueda de biomarcadores en la ... -
Is the phenotype designation by PSP-MDS criteria stable throughout the disease course and consistent with tau distribution?
Introduction: the MDS-PSP criteria have shown high sensitivity for the PSP diagnosis, but do not discriminate the phenotype diversity. Our purpose was to search for anatomopathological differences among PSP phenotypes ... -
Liquid biopsy in alzheimer's disease patients reveals epigenetic changes in the PRLHR gene
In recent years, new DNA methylation variants have been reported in genes biologically relevant to Alzheimer’s disease (AD) in human brain tissue. However, this AD-specific epigenetic information remains brain-locked and ... -
NXN gene epigenetic changes in an adult neurogenesis model of Alzheimer's disease
In view of the proven link between adult hippocampal neurogenesis (AHN) and learning and memory impairment, we generated a straightforward adult neurogenesis in vitro model to recapitulate DNA methylation marks in the ...