• Aldosterone impairs mitochondrial function in human cardiac fibroblasts via A-kinase anchor protein 12 

      Ibarrola Ulzurrun, Jaime Francisco Upna; Sádaba Sagredo, Rafael; Martínez Martínez, Ernesto; García Peña, Amaia; Gaínza Calleja, Alicia (Springer, 2018)   Artículo / Artikulua  OpenAccess
      Aldosterone (Aldo) contributes to mitochondrial dysfunction and cardiac oxidative stress. Using a proteomic approach, A-kinase anchor protein (AKAP)-12 has been identified as a down-regulated protein by Aldo in human cardiac ...
    • Characterization of the sex-specific pattern of angiogenesis and lymphangiogenesis in aortic stenosis 

      Matilla Cuenca, Lara; Martín Núñez, Ernesto; Garaikoetxea, Mattie; Navarro, Adela; Vico, Julieta Anabela; Arrieta Paniagua, Vanessa; García Peña, Amaia; Fernández Celis, Amaya; Gaínza Calleja, Alicia; Álvarez, Virginia; Sádaba Sagredo, Rafael; López Andrés, Natalia; Jover, Eva (Frontiers Media, 2022)   Artículo / Artikulua  OpenAccess
      Objective: We aim to analyze sex-related differences in angiogenesis and lymphangiogenesis in aortic valves (AVs) and valve interstitial cells (VICs) from aortic stenosis (AS) patients. Approach and Results: Totally 230 ...
    • Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis 

      Jover, Eva; Matilla Cuenca, Lara; Martín Núñez, Ernesto; Garaikoetxea Zubillaga, Mattie; Navarro, Adela; Fernández Celis, Amaya; Gaínza Calleja, Alicia; Arrieta Paniagua, Vanessa; García Peña, Amaia; Álvarez, Virginia; Sádaba Sagredo, Rafael; Jaisser, Frederic; López Andrés, Natalia (BMC, 2022)   Artículo / Artikulua  OpenAccess
      Background: Accumulating evidence suggest the existence of sex-related differences in the pathogenesis of aortic stenosis (AS) with inflammation, oxidative stress, fibrosis and calcification being over-represented in men. ...
    • Soluble ST2 as a new oxidative stress and inflammation marker in metabolic syndrome 

      Roy, Ignacio; Jover, Eva; Matilla Cuenca, Lara; Álvarez, Virginia; Fernández Celis, Amaya; Beunza, Maite; Escribano, Elena; Gaínza Calleja, Alicia; Sádaba Sagredo, Rafael; López Andrés, Natalia (MDPI, 2023)   Artículo / Artikulua  OpenAccess
      Background: Metabolic syndrome (MS) is a complex and prevalent disorder. Oxidative stress and inflammation might contribute to the progression of MS. Soluble ST2 (sST2) is an attractive and druggable molecule that sits at ...
    • Targeting fatty acid-binding protein 4 improves pathologic features of aortic stenosis 

      Garaikoetxea, Mattie; Martín Núñez, Ernesto; Navarro, Adela; Matilla Cuenca, Lara; Fernández Celis, Amaya; Arrieta Paniagua, Vanessa; García Peña, Amaia; Gaínza Calleja, Alicia; Álvarez, Virginia; Sádaba Sagredo, Rafael; Jover, Eva; López Andrés, Natalia (MDPI, 2022)   Artículo / Artikulua  OpenAccess
      Aortic stenosis (AS) is a fibrocalcific disease of the aortic valves (AVs). Sex-differences in AS pathophysiology have recently been described. High levels of fatty acid-binding protein 4 (FAPB4) in atherosclerotic plaques ...

      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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