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PD1 signal transduction pathways in T cells
(Impact Journals, 2017)
Artículo / Artikulua,
The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating ...
PDL1 signals through conserved sequence motifs to overcome interferon-mediated cytotoxicity
(Elsevier, 2017)
Artículo / Artikulua,
PDL1 blockade produces remarkable clinical responses, thought to occur by T cell reactivation
through prevention of PDL1-PD1 T cell inhibitory interactions. Here, we find that PDL1 cell-intrinsic
signaling protects cancer ...