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  • Molecular and insecticidal characterization of a novel cry-related protein from bacillus thuringiensis toxic against Myzus persicae 

    Palma Dovis, Leopoldo; Muñoz Labiano, Delia; Berry, Colin; Murillo Martínez, Jesús; Escudero, Iñigo de; Caballero Murillo, Primitivo (MDPI, 2014)   Artículo / Artikulua
    This study describes the insecticidal activity of a novel Bacillus thuringiensis Cry-related protein with a deduced 799 amino acid sequence (~89 kDa) and ~19% pairwise identity to the 95-kDa-aphidicidal protein (sequence ...
  • Bacillus thuringiensis toxins: an overview of their biocidal activity 

    Palma Dovis, Leopoldo; Muñoz, Delia; Berry, Colin; Murillo Martínez, Jesús; Caballero Murillo, Primitivo (MDPI, 2014)   Artículo / Artikulua
    Bacillus thuringiensis (Bt) is a Gram positive, spore-forming bacterium that synthesizes parasporal crystalline inclusions containing Cry and Cyt proteins, some of which are toxic against a wide range of insect orders, ...
  • The Vip3Ag4 insecticidal protoxin from bacillus thuringiensis adopts a tetrameric configuration that is maintained on proteolysis 

    Palma Dovis, Leopoldo; Scott, David J.; Harris, Gemma; Din, Salah-Ud; Williams, Thomas L.; Roberts, Oliver J.; Young, Mark T.; Caballero Murillo, Primitivo; Berry, Colin (MDPI, 2017)   Artículo / Artikulua
    The Vip3 proteins produced during vegetative growth by strains of the bacterium Bacillus thuringiensis show insecticidal activity against lepidopteran insects with a mechanism of action that may involve pore formation and ...
  • Immunization against small ruminant lentiviruses 

    Reina Arias, Ramsés; Andrés Cara, Damián de; Amorena Zabalza, Beatriz (MDPI, 2013)   Artículo / Artikulua
    Multisystemic disease caused by Small Ruminant Lentiviruses (SRLV) in sheep and goats leads to production losses, to the detriment of animal health and welfare. This, together with the lack of treatments, has triggered ...
  • Effect of feeding regime on composting in bins 

    Storino, Francesco; Menéndez Villanueva, Sergio; Muro Erreguerena, Julio; Aparicio Tejo, Pedro María; Irigoyen Iriarte, Ignacio (Taylor & Francis, 2017)   Artículo / Artikulua
    Composting in bins is one of the most practical home composting methods. There is currently a need for greater information to improve the management of the composting process and to create home composting programs, which ...
  • Gender-mediated differences in vertical transmission of a nucleopolyhedrovirus 

    Virto Garayoa, Cristina; Zárate Chaves, Carlos Andrés; López Ferber, Miguel; Murillo Pérez, Rosa; Caballero Murillo, Primitivo; Williams, Trevor (Public Library of Science, 2013)   Artículo / Artikulua
    With the development of sensitive molecular techniques for detection of low levels of asymptomatic pathogens, it becoming clear that vertical transmission is a common feature of some insect pathogenic viruses, and likely ...
  • An effort to make sense of antisense transcription in bacteria 

    Lasa Uzcudun, Íñigo; Toledo Arana, Alejandro; Gingeras, Thomas R. (Taylor & Francis, 2012)   Artículo / Artikulua
    Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some ...
  • Overlapping transcription and bacterial RNA removal 

    Lasa Uzcudun, Íñigo; Villanueva San Martín, Maite (National Academy of Sciences, 2014)   Artículo / Artikulua
    The precise understanding of the biology of a living cell requires the identification and quantification of the molecular components necessary to sustain life. One such element is RNA. Two independent high-throughput ...
  • Staphylococcal Bap proteins build amyloid scaffold biofilm matrices in response to environmental signals 

    Taglialegna, Agustina; Navarro, Susanna; Ventura, Salvador; Garnett, James A.; Matthews, Steve; Penadés, José R.; Lasa Uzcudun, Íñigo; Valle Turrillas, Jaione (Public Library of Science, 2016)   Artículo / Artikulua
    Major components of the biofilm matrix scaffold are proteins that assemble to create a unified structure that maintain bacteria attached to each other and to surfaces. We provide evidence that a surface protein present in ...
  • Amyloid structures as biofilm matrix scaffolds 

    Taglialegna, Agustina; Lasa Uzcudun, Íñigo; Valle Turrillas, Jaione (American Society for Microbiology, 2016)   Artículo / Artikulua
    Recent insights into bacterial biofilm matrix structures have induced a paradigm shift toward the recognition of amyloid fibers as common building block structures that confer stability to the exopolysaccharide matrix. ...
  • Genome-wide antisense transcription drives mRNA processing in bacteria 

    Lasa Uzcudun, Íñigo; Toledo Arana, Alejandro; Dobin, Alexander; Villanueva San Martín, Maite; Ruiz de los Mozos Aliaga, Igor; Vergara Irigaray, Marta; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R.; Valle Turrillas, Jaione; Solano Goñi, Cristina; Gingeras, Thomas R. (National Academy of Sciences, 2011)   Artículo / Artikulua
    RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5′ and 3′ untranslated regions, and alternative ...
  • Salmonella biofilm development depends on the phosphorylation status of RcsB 

    Latasa Osta, Cristina; García Martínez, Begoña; Echeverz Sarasúa, Maite; Toledo Arana, Alejandro; Valle Turrillas, Jaione; Campoy Sánchez, Susana; García del Portillo, Francisco; Solano Goñi, Cristina; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2012)   Artículo / Artikulua
    The Rcs phosphorelay pathway is a complex signaling pathway involved in the regulation of many cell surface structures in enteric bacteria. In response to environmental stimuli, the sensor histidine kinase (RcsC) ...
  • Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor 

    Valle Turrillas, Jaione; Latasa Osta, Cristina; Gil Puig, Carmen; Toledo Arana, Alejandro; Solano Goñi, Cristina; Penadés, José R.; Lasa Uzcudun, Íñigo (Public Library of Science, 2012)   Artículo / Artikulua
    The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ...
  • Coordinated cyclic-di-GMP repression of salmonella motility through YcgR and cellulose 

    Zorraquino Salvo, Violeta; García Martínez, Begoña; Latasa Osta, Cristina; Echeverz Sarasúa, Maite; Toledo Arana, Alejandro; Valle Turrillas, Jaione; Lasa Uzcudun, Íñigo; Solano Goñi, Cristina (American Society for Microbiology, 2013)   Artículo / Artikulua
    Cyclic di-GMP (c-di-GMP) is a secondary messenger that controls a variety of cellular processes, including the switch between a biofilm and a planktonic bacterial lifestyle. This nucleotide binds to cellular effectors in ...
  • Biofilm switch and immune response determinants at early stages of infection 

    Valle Turrillas, Jaione; Solano Goñi, Cristina; García Martínez, Begoña; Toledo Arana, Alejandro; Lasa Uzcudun, Íñigo (Elsevier (Cell Press), 2013)   Artículo / Artikulua
    Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a ...
  • Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection 

    Gil Puig, Carmen; Solano Goñi, Cristina; Burgui Erice, Saioa; Latasa Osta, Cristina; García Martínez, Begoña; Toledo Arana, Alejandro; Lasa Uzcudun, Íñigo; Valle Turrillas, Jaione (American Society for Microbiology, 2014)   Artículo / Artikulua
    The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ...
  • Biofilm dispersion and quorum sensing 

    Solano Goñi, Cristina; Echeverz Sarasúa, Maite; Lasa Uzcudun, Íñigo (Elsevier, 2014)   Artículo / Artikulua
    Biofilm development and quorum sensing are closely interconnected processes. Biofilm formation is a cooperative group behaviour that involves bacterial populations living embedded in a self produced extracellular matrix. ...
  • Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling 

    Valle Turrillas, Jaione; Burgui Erice, Saioa; Langheinrich, Denise; Gil Puig, Carmen; Solano Goñi, Cristina; Toledo Arana, Alejandro; Helbig, Ralf; Lasagni, Andrés; Lasa Uzcudun, Íñigo (2015)   Artículo / Artikulua
    Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial ...
  • Evaluation of a Salmonella strain lacking the secondary messenger c-di-GMP and RpoS as a live oral vaccine 

    Latasa Osta, Cristina; Echeverz Sarasúa, Maite; García Ona, Enrique; Burgui Erice, Saioa; Casares, Noelia; Hervás Stubbs, Sandra; Lasarte, Juan José; Lasa Uzcudun, Íñigo; Solano Goñi, Cristina; García Martínez, Begoña; Gil Puig, Carmen (Public Library of Science, 2016)   Artículo / Artikulua
    Salmonellosis is one of the most important bacterial zoonotic diseases transmitted through the consumption of contaminated food, with chicken and pig related products being key reservoirs of infection. Although numerous ...
  • Mechanisms of ammonium toxicity and the quest for tolerance 

    Esteban Terradillos, Raquel; Ariz, Idoia; Cruz, Cristina; Morán Juez, José Fernando (Elsevier, 2016)   Artículo / Artikulua
    Ammonium sensitivity of plants is a worldwide problem, constraining crop production. Prolonged application of ammonium as the sole nitrogen source may result in physiological and morphological disorders that lead to decreased ...

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