Now showing items 1-20 of 160

    • Overexpression of thioredoxin m in tobacco chloroplasts inhibits the protein kinase STN7 and alters photosynthetic performance 

      Ancín Rípodas, María Upna; Fernández San Millán, Alicia Upna; Larraya Reta, Luis María Upna; Morales Iribas, Fermín; Veramendi Charola, Jon Upna; Aranjuelo Michelena, Iker; Farrán Blanch, Inmaculada Upna (Oxford University Press, 2019)   Artículo / Artikulua  OpenAccess
      The activity of the protein kinase STN7, involved in phosphorylation of the light-harvesting complex II (LHCII) proteins, has been reported as being co-operatively regulated by the redox state of the plastoquinone pool ...
    • Noncontiguous operon is a genetic organization for coordinating bacterial gene expression 

      Sáenz Lahoya, S.; Bitarte, Nerea Upna; Garcia, B.; Burgui Erice, Saioa Upna; Vergara Irigaray, Marta Upna; Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; Toledo Arana, Alejandro Upna; Lasa Uzcudun, Íñigo Upna (National Academy of Sciences, 2019)   Artículo / Artikulua  OpenAccess
      Bacterial genes are typically grouped into operons defined as clusters of adjacent genes encoding for proteins that fill related roles and are transcribed into a single polycistronic mRNA molecule. This simple organization ...
    • Expression analysis of lung miRNAs responding to ovine VM virus infection by RNA-seq 

      Bilbao Arribas, Martin; Abendaño, Naiara; Varela Martínez, Endika; Reina Arias, Ramsés Upna; Andrés Cara, Damián de Upna; Jugo, Begoña M. (BioMed Central, 2019)   Artículo / Artikulua  OpenAccess
      Background: MicroRNAs (miRNAs) are short endogenous, single-stranded, noncoding small RNA molecules of approximately 22 nucleotides in length. They regulate gene expression posttranscriptionally by silencing mRNA expression, ...
    • A cAMP/CRP-controlled mechanism for the incorporation of extracellular ADP-glucose in Escherichia coli involving NupC and NupG nucleoside transporters 

      Almagro Zabalza, Goizeder Upna; Viale, Alejandro M. Upna; Montero Macarro, Manuel Upna; Muñoz Pérez, Francisco José Upna; Baroja Fernández, Edurne Upna; Mori, Hirotada; Pozueta Romero, Javier Upna (Nature Research, 2018)   Artículo / Artikulua  OpenAccess
      ADP-glucose is the precursor of glycogen biosynthesis in bacteria, and a compound abundant in the starchy plant organs ingested by many mammals. Here we show that the enteric species Escherichia coli is capable of scavenging ...
    • Plastidial phosphoglucose isomerase is an important determinant of seed yield through its involvement in gibberellin-mediated reproductive development and storage reserve biosynthesis in arabidopsis 

      Bahaji, Abdellatif Upna; Almagro Zabalza, Goizeder Upna; Ezquer, Ignacio; Gámez Arcas, Samuel Upna; Sánchez López, Ángela María; Muñoz Pérez, Francisco José Upna; Barrio, Ramón José; Sampedro, M. Carmen; Diego, Nuria de; Spíchal, Lukás; Dolezal, Karel; Tarkowská, Danuse; Caporali, Elisabetta; Mendes, Marta Adelina; Baroja Fernández, Edurne Upna; Pozueta Romero, Javier Upna (American Society of Plant Biologists, 2018)   Artículo / Artikulua  OpenAccess
      The plastid-localized phosphoglucose isomerase isoform PGI1 is an important determinant of growth in Arabidopsis thaliana, likely due to its involvement in the biosynthesis of plastidial isoprenoid-derived hormones. Here, ...
    • Sensory deprivation in Staphylococcus aureus 

      Villanueva San Martín, Maite Upna; García Martínez, Begoña Upna; Valle Turrillas, Jaione Upna; Rapún Araiz, Beatriz Upna; Ruiz de los Mozos Aliaga, Igor Upna; Solano Goñi, Cristina Upna; Martí, Miguel; Penadés, José R.; Toledo Arana, Alejandro Upna; Lasa Uzcudun, Íñigo Upna (Springer Nature, 2018)   Artículo / Artikulua  OpenAccess
      Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show ...
    • Identification of lptA, lpxE, and lpxO, three genes involved in the remodeling of Brucella cell envelope 

      Conde Álvarez, Raquel; Palacios Chaves, Leyre; Gil Ramírez, Yolanda Upna; Salvador Bescós, Miriam; Bárcena Varela, Marina; Aragón Aranda, Beatriz; Martínez Gómez, Estrella; Zúñiga Ripa, Amaia; Miguel López, María Jesús de; Bartholomew, Toby Leigh; Hanniffy, Sean; Grilló Dolset, María Jesús; Vences Guzmán, Miguel Ángel; Bengoechea Alonso, José Antonio; Arce Gorvel, Vilma; Gorvel, Jean-Pierre; Moriyón Uría, Ignacio; Iriarte, Maite (Frontiers Media, 2018)   Artículo / Artikulua  OpenAccess
      The brucellae are facultative intracellular bacteria that cause a worldwide extended zoonosis. One of the pathogenicity mechanisms of these bacteria is their ability to avoid rapid recognition by innate immunity because ...
    • The regulon of the RNA chaperone CspA and its auto-regulation in Staphylococcus aureus 

      Caballero Sánchez, Carlos Upna; Menéndez Gil, Pilar; Catalán Moreno, Arancha; Vergara Irigaray, Marta Upna; García Martínez, Begoña Upna; Segura, Víctor; Irurzun Domínguez, Naiara; Villanueva San Martín, Maite Upna; Ruiz de los Mozos Aliaga, Igor Upna; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna; Toledo Arana, Alejandro Upna (Oxford University Press, 2018)   Artículo / Artikulua  OpenAccess
      RNA-binding proteins (RBPs) are essential to finetune gene expression. RBPs containing the coldshock domain are RNA chaperones that have been extensively studied. However, the RNA targets and specific functions for ...
    • Molecular signature of aluminum hydroxide adjuvant in ovine PBMCs by integrated mRNA and microRNA transcriptome sequencing 

      Varela Martínez, Endika; Abendaño, Naiara; Asín, Javier; Sistiaga Poveda, Maialen; Pérez, Marta María; Reina Arias, Ramsés Upna; Andrés Cara, Damián de Upna; Luján, Lluís; Jugo, Begoña M. (Frontiers Media, 2018)   Artículo / Artikulua  OpenAccess
      There have been few in vivo studies on the effect of aluminum hydroxide adjuvant and its influence on the immune response to vaccination. In this study, lambs received a parallel subcutaneous treatment with either commercial ...
    • Proteomics analysis reveals non-controlled activation of photosynthesis and protein synthesis in a rice npp1 mutant under high temperature and elevated CO2 conditions 

      Inomata, Takuya; Baslam, Marouane Upna; Masui, Takahiro; Koshu, Tsutomu; Takamatsu, Takeshi; Kaneko, Kentaro; Pozueta Romero, Javier Upna; Mitsui, Toshiaki (MDPI, 2018)   Artículo / Artikulua  OpenAccess
      Rice nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) catalyzes the hydrolytic breakdown of the pyrophosphate and phosphodiester bonds of a number of nucleotides including ADP-glucose and ATP. Under high temperature ...
    • Antagonistic pleiotropy in the bifunctional surface protein fadl (OmpP1) during adaptation of Haemophilus influenzae to chronic lung infection associated with chronic obstructive pulmonary disease 

      Moleres Apilluelo, Javier Upna; Fernández Calvet, Ariadna Upna; Ehrlich, Rachel L.; Martí, Sara; Pérez Regidor, Lucía; Euba, Begoña; Rodríguez Arce, Irene Upna; Balashov, Sergey; Cuevas, Ester; Liñares, Josefina; Ardanuy, Carmen; Martín Santamaría, Sonsoles; Ehrlich, Garth D.; Mell, Joshua Chang; Garmendia, Junkal (American Society for Microbiology, 2018)   Artículo / Artikulua  OpenAccess
      Tracking bacterial evolution during chronic infection provides insights into how host selection pressures shape bacterial genomes. The human-restricted opportunistic pathogen nontypeable Haemophilus influenzae (NTHi) infects ...
    • Effect of feeding regime on composting in bins 

      Storino, Francesco Upna; Menéndez Villanueva, Sergio Upna; Muro Erreguerena, Julio Upna; Aparicio Tejo, Pedro María Upna; Irigoyen Iriarte, Ignacio Upna (Taylor & Francis, 2017)   Artículo / Artikulua  OpenAccess
      Composting in bins is one of the most practical home composting methods. There is currently a need for greater information to improve the management of the composting process and to create home composting programs, which ...
    • Lentinula edodes β-glucan enriched diet induces pro- and anti-inflammatory macrophages in rabbit 

      Crespo, Helena Upna; Guillén, Hugo; Pablo Maiso, Lorena de; Gómez Arrebola, Carmen Upna; Rodríguez, Gregorio; Glaría Ezquer, Idoia Upna; Andrés Cara, Damián de Upna; Reina Arias, Ramsés Upna (Taylor & Francis, 2017)   Artículo / Artikulua  OpenAccess
      β-glucans exhibited in cell walls of several pathogens as bacteria or fungi are sensed by pathogen recognition receptors such as scavenger receptors present in antigen presenting cells, i.e., macrophages. β-glucans obtained ...
    • Inactivation of the Thymidylate synthase thyA in non-typeable Haemophilus influenzae modulates antibiotic resistance and has a strong impact on its interplay with the host airways 

      Rodríguez Arce, Irene Upna; Martí, Sara; Euba, Begoña; Fernández Calvet, Ariadna Upna; Moleres Apilluelo, Javier Upna; López López, Nahikari Upna; Barberán, Montserrat; Ramos Vivas, José; Tubau, Fe; Losa, Carmen; Ardanuy, Carmen; Leiva, José; Yuste, José E.; Garmendia García, Juncal (Frontiers Media, 2017)   Artículo / Artikulua  OpenAccess
      Antibacterial treatment with cotrimoxazol (TxS), a combination of trimethoprim and sulfamethoxazole, generates resistance by, among others, acquisition of thymidine auxotrophy associated with mutations in the thymidylate ...
    • Apoptosis, toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens 

      Martínez, Isidoro; Oliveros, Juan C.; Cuesta, Isabel; Barrera, Jorge de la; Ausina, Vicente; Casals, Cristina; Lorenzo, Alba de; García, Ernesto; García Fojeda, Belén; Garmendia García, Juncal; González Nicolau, Mar; Lacoma, Alicia; Menéndez, Margarita; Moranta, David; Nieto, Amelia; Ortín, Juan; Pérez González, Alicia; Prat, Cristina; Ramos Sevillano, Elisa; Regueiro, Verónica; Rodríguez Frandsen, Ariel; Solís, Dolores; Yuste, José E.; Bengoechea Alonso, José Antonio; Melero, José A. (Frontiers Media, 2017)   Artículo / Artikulua  OpenAccess
      Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by ...
    • Resveratrol therapeutics combines both antimicrobial and immunomodulatory properties against respiratory infection by nontypeable Haemophilus influenzae 

      Euba, Begoña; López López, Nahikari Upna; Rodríguez Arce, Irene Upna; Fernández Calvet, Ariadna Upna; Barberán, Montserrat; Caturla, Nuria; Martí, Sara; Díez Martínez, Roberto; Garmendia, Junkal (Springer Nature, 2017)   Artículo / Artikulua  OpenAccess
      The respiratory pathogen nontypeable Haemophilus influenzae (NTHi) is an important cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) that requires efficient treatments. A previous screening ...
    • Characterization of ovine A3Z1 restriction properties against small ruminant lentiviruses (SRLVs) 

      Pablo Maiso, Lorena de; Glaría Ezquer, Idoia Upna; Crespo, Helena Upna; Nistal Villán, Estanislao; Andrésdóttir, Valgerdur; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Reina Arias, Ramsés Upna (MDPI, 2017)   Artículo / Artikulua  OpenAccess
      Intrinsic factors of the innate immune system include the apolipoprotein B editing enzyme catalytic polypeptide-like 3 (APOBEC3) protein family. APOBEC3 inhibits replication of different virus families by cytosine ...
    • The Vip3Ag4 insecticidal protoxin from bacillus thuringiensis adopts a tetrameric configuration that is maintained on proteolysis 

      Palma Dovis, Leopoldo Upna; Scott, David J.; Harris, Gemma; Din, Salah-Ud; Williams, Thomas L.; Roberts, Oliver J.; Young, Mark T.; Caballero Murillo, Primitivo Upna; Berry, Colin (MDPI, 2017)   Artículo / Artikulua  OpenAccess
      The Vip3 proteins produced during vegetative growth by strains of the bacterium Bacillus thuringiensis show insecticidal activity against lepidopteran insects with a mechanism of action that may involve pore formation and ...
    • Lack of the PGA exopolysaccharide in Salmonella as an adaptive trait for survival in the host 

      Echeverz Sarasúa, Maite Upna; García Martínez, Begoña Upna; Sabalza Baztán, Amaia Upna; Valle Turrillas, Jaione Upna; Gabaldón Estevan, Juan Antonio; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna (Public Library of Science, 2017)   Artículo / Artikulua  OpenAccess
      Many bacteria build biofilm matrices using a conserved exopolysaccharide named PGA or PNAG (poly-β-1,6-N-acetyl-D-glucosamine). Interestingly, while E. coli and other members of the family Enterobacteriaceae encode the ...
    • Chrysodeixis chalcites nucleopolyhedrovirus (ChchNPV): natural occurrence and efficacy as a biological insecticide on young banana plants in greenhouse and open-field conditions on the Canary Islands 

      Fuentes Barrera, Ernesto Gabriel; Hernández Suárez, Estrella; Simón de Goñi, Oihane Upna; Williams, Trevor Upna; Caballero Murillo, Primitivo Upna (Public Library of Science, 2017)   Artículo / Artikulua  OpenAccess
      Chrysodeixis chalcites, an important pest of banana crops on the Canary Islands, is usually controlled by chemical insecticides. The present study aimed to evaluate the efficacy of the most prevalent isolate of the ...