• Amyloid structures as biofilm matrix scaffolds 

      Taglialegna, Agustina; Lasa Uzcudun, Íñigo; Valle Turrillas, Jaione (American Society for Microbiology, 2016)   Artículo / Artikulua
      Recent insights into bacterial biofilm matrix structures have induced a paradigm shift toward the recognition of amyloid fibers as common building block structures that confer stability to the exopolysaccharide matrix. ...
    • Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor 

      Valle Turrillas, Jaione; Latasa Osta, Cristina; Gil Puig, Carmen; Toledo Arana, Alejandro; Solano Goñi, Cristina; Penadés, José R.; Lasa Uzcudun, Íñigo (Public Library of Science, 2012)   Artículo / Artikulua
      The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ...
    • Base pairing interaction between 5′- and 3′-UTRs controls icaR mRNA translation in Staphylococcus aureus 

      Ruiz de los Mozos Aliaga, Igor; Vergara Irigaray, Marta; Segura, Víctor; Villanueva San Martín, Maite; Bitarte, Nerea; Saramago, Margarida; Domingues, Susana; Arraiano, Cecilia M.; Fechter, Pierre; Romby, Pascale; Valle Turrillas, Jaione; Solano Goñi, Cristina; Lasa Uzcudun, Íñigo; Toledo Arana, Alejandro (Public Library of Science, 2013)   Artículo / Artikulua
      The presence of regulatory sequences in the 39 untranslated region (39-UTR) of eukaryotic mRNAs controlling RNA stability and translation efficiency is widely recognized. In contrast, the relevance of 39-UTRs in bacterial ...
    • Biofilm dispersion and quorum sensing 

      Solano Goñi, Cristina; Echeverz Sarasúa, Maite; Lasa Uzcudun, Íñigo (Elsevier, 2014)   Artículo / Artikulua
      Biofilm development and quorum sensing are closely interconnected processes. Biofilm formation is a cooperative group behaviour that involves bacterial populations living embedded in a self produced extracellular matrix. ...
    • Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection 

      Gil Puig, Carmen; Solano Goñi, Cristina; Burgui Erice, Saioa; Latasa Osta, Cristina; García Martínez, Begoña; Toledo Arana, Alejandro; Lasa Uzcudun, Íñigo; Valle Turrillas, Jaione (American Society for Microbiology, 2014)   Artículo / Artikulua
      The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ...
    • Biofilm switch and immune response determinants at early stages of infection 

      Valle Turrillas, Jaione; Solano Goñi, Cristina; García Martínez, Begoña; Toledo Arana, Alejandro; Lasa Uzcudun, Íñigo (Elsevier (Cell Press), 2013)   Artículo / Artikulua
      Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a ...
    • Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern 

      Palacios Chaves, Leyre; Conde Álvarez, Raquel; Gil Ramírez, Yolanda; Zúñiga Ripa, Amaia; Barquero Calvo, Elías; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Arce Gorvel, Vilma; Gorvel, Jean-Pierre; Moreno, Edgardo; Miguel, María Jesús de; Grilló Dolset, María Jesús; Moriyón Uría, Ignacio; Iriarte, Maite (Public Library of Science, 2011)   Artículo / Artikulua
      The brucellae are alpha-Proteobacteria facultative intracellular parasites that cause an important zoonosis. These bacteria escape early detection by innate immunity, an ability associated to the absence of marked ...
    • Brucellosis vaccines: assessment of brucella melitensis lipopolysaccharide rough mutants defective in core and O-polysaccharide synthesis and export 

      González, David; Grilló Dolset, María Jesús; Miguel, María Jesús de; Ali, Tara; Arce Gorvel, Vilma; Delrue, Rose May; Conde Álvarez, Raquel; Muñoz Álvaro, Pilar María; López Goñi, Ignacio; Iriarte, Maite; Marín, Clara M.; Weintraub, Andrej; Widmalm, Goeran; Zygmunt, Michel; Letesson, Jean-Jacques; Gorvel, Jean-Pierre; Blasco, José María; Moriyón Uría, Ignacio (Public Library of Science, 2008)   Artículo / Artikulua
      Background: The brucellae are facultative intracellular bacteria that cause brucellosis, one of the major neglected zoonoses. In endemic areas, vaccination is the only effective way to control this disease. Brucella ...
    • Coordinated cyclic-di-GMP repression of salmonella motility through YcgR and cellulose 

      Zorraquino Salvo, Violeta; García Martínez, Begoña; Latasa Osta, Cristina; Echeverz Sarasúa, Maite; Toledo Arana, Alejandro; Valle Turrillas, Jaione; Lasa Uzcudun, Íñigo; Solano Goñi, Cristina (American Society for Microbiology, 2013)   Artículo / Artikulua
      Cyclic di-GMP (c-di-GMP) is a secondary messenger that controls a variety of cellular processes, including the switch between a biofilm and a planktonic bacterial lifestyle. This nucleotide binds to cellular effectors in ...
    • Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine 

      Mancilla, Marcos; Grilló Dolset, María Jesús; Miguel López, María Jesús de; López Goñi, Ignacio; San Román Aberasturi, Beatriz; Zabalza Baranguá, Ana; Moriyón Uría, Ignacio (BioMed Central, 2013)   Artículo / Artikulua
      Brucella melitensis Rev 1 is the best vaccine available for the prophylaxis of small ruminant brucellosis and, indirectly, for reducing human brucellosis. However, Rev 1 shows anomalously high rates of spontaneous dissociation ...
    • Depletion of the heaviest stable N isotope is associated with NH4+/NH3 toxicity in NH4+-fed plants 

      Ariz, Idoia; Cruz, Cristina; Morán Juez, José Fernando; González Moro, María B.; García Olaverri, Carmen; González Murua, Carmen; Martins Loucao, María A.; Aparicio Tejo, Pedro María (BioMed Central, 2011)   Artículo / Artikulua
      Background: In plants, nitrate (NO3-) nutrition gives rise to a natural N isotopic signature (δ15N), which correlates with the δ15N of the N source. However, little is known about the relationship between the δ15N of the ...
    • Draft genome sequences of two bacillus thuringiensis strains and characterization of a putative 41.9-kDa insecticidal toxin 

      Palma Dovis, Leopoldo; Muñoz, Delia; Berry, Colin; Murillo Martínez, Jesús; Caballero Murillo, Primitivo (MDPI, 2014)   Artículo / Artikulua
      In this work, we report the genome sequencing of two Bacillus thuringiensis strains using Illumina next-generation sequencing technology (NGS). Strain Hu4-2, toxic to many lepidopteran pest species and to some mosquitoes, ...
    • Effect of feeding regime on composting in bins 

      Storino, Francesco; Menéndez Villanueva, Sergio; Muro Erreguerena, Julio; Aparicio Tejo, Pedro María; Irigoyen Iriarte, Ignacio (Taylor & Francis, 2017)   Artículo / Artikulua
      Composting in bins is one of the most practical home composting methods. There is currently a need for greater information to improve the management of the composting process and to create home composting programs, which ...
    • An effort to make sense of antisense transcription in bacteria 

      Lasa Uzcudun, Íñigo; Toledo Arana, Alejandro; Gingeras, Thomas R. (Taylor & Francis, 2012)   Artículo / Artikulua
      Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some ...
    • Evaluation of a Salmonella strain lacking the secondary messenger c-di-GMP and RpoS as a live oral vaccine 

      Latasa Osta, Cristina; Echeverz Sarasúa, Maite; García Ona, Enrique; Burgui Erice, Saioa; Casares, Noelia; Hervás Stubbs, Sandra; Lasarte, Juan José; Lasa Uzcudun, Íñigo; Solano Goñi, Cristina; García Martínez, Begoña; Gil Puig, Carmen (Public Library of Science, 2016)   Artículo / Artikulua
      Salmonellosis is one of the most important bacterial zoonotic diseases transmitted through the consumption of contaminated food, with chicken and pig related products being key reservoirs of infection. Although numerous ...
    • Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling 

      Valle Turrillas, Jaione; Burgui Erice, Saioa; Langheinrich, Denise; Gil Puig, Carmen; Solano Goñi, Cristina; Toledo Arana, Alejandro; Helbig, Ralf; Lasagni, Andrés; Lasa Uzcudun, Íñigo (2015)   Artículo / Artikulua
      Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial ...
    • The extradomain a of fibronectin enhances the efficacy of lipopolysaccharide defective Salmonella bacterins as vaccines in mice 

      San Román Aberasturi, Beatriz; Lasa Uzcudun, Íñigo; Andrés Cara, Damián de; Amorena Zabalza, Beatriz; Lasarte, Juan José; Grilló Dolset, María Jesús; Garrido, Victoria; Muñoz Álvaro, Pilar María; Arribillaga, Laura; García Martínez, Begoña; Andrés, Ximena de; Zabaleta, Virginia; Mansilla, Cristina; Farrán Blanch, Inmaculada (BioMed Central, 2012)   Artículo / Artikulua
      The Extradomain A from fibronectin (EDA) has an immunomodulatory role as fusion protein with viral and tumor antigens, but its effect when administered with bacteria has not been assessed. Here, we investigated the adjuvant ...
    • Gender-mediated differences in vertical transmission of a nucleopolyhedrovirus 

      Virto Garayoa, Cristina; Zárate Chaves, Carlos Andrés; López Ferber, Miguel; Murillo Pérez, Rosa; Caballero Murillo, Primitivo; Williams, Trevor (Public Library of Science, 2013)   Artículo / Artikulua
      With the development of sensitive molecular techniques for detection of low levels of asymptomatic pathogens, it becoming clear that vertical transmission is a common feature of some insect pathogenic viruses, and likely ...
    • Genome-wide antisense transcription drives mRNA processing in bacteria 

      Lasa Uzcudun, Íñigo; Toledo Arana, Alejandro; Dobin, Alexander; Villanueva San Martín, Maite; Ruiz de los Mozos Aliaga, Igor; Vergara Irigaray, Marta; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R.; Valle Turrillas, Jaione; Solano Goñi, Cristina; Gingeras, Thomas R. (National Academy of Sciences, 2011)   Artículo / Artikulua
      RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5′ and 3′ untranslated regions, and alternative ...
    • Genome-wide screening of genes whose enhanced expression affects glycogen accumulation in Escherichia coli 

      Eydallin, Gustavo; Montero Macarro, Manuel; Almagro Zabalza, Goizeder; Sesma Pascual, María Teresa; Viale, Alejandro M.; Muñoz, Francisco José; Rahimpour, Mehdi; Baroja Fernández, Edurne; Pozueta Romero, Javier (Oxford University Press, 2010)   Artículo / Artikulua
      Using a systematic and comprehensive gene expression library (the ASKA library), we have carried out a genome-wide screening of the genes whose increased plasmid-directed expression affected glycogen metabolism in Escherichia ...