Th17-related genes and celiac disease susceptibility
Medrano, Luz María
García Magariños, Manuel
Figueredo, María Ángeles
Fernández Arquero, Miguel
Acceso abierto / Sarbide irekiainfo:eu-repo/semantics/openAccess
Artículo / Artikuluainfo:eu-repo/semantics/article
Versión publicada / Argitaratu den bertsioainfo:eu-repo/semantics/publishedVersion
Th17 cells are known to be involved in several autoimmune or inflammatory diseases. In celiac disease (CD), recent studies suggest an implication of those cells in disease pathogenesis. We aimed at studying the role of genes relevant for the Th17 immune response in CD susceptibility. A total of 101 single nucleotide polymorphisms (SNPs), mainly selected to cover most of the variability present in 16 Th17-related genes (IL23R, RORC, IL6R, IL17A, IL17F, CCR6, IL6, JAK2, TNFSF15, IL23A, IL22, STAT3, TBX21, SOCS3, IL12RB1 and IL17RA), were genotyped in 735 CD patients and 549 ethnically matched healthy controls. Case-control comparisons for each SNP and for the haplotypes resulting from the SNPs studied in each gene were performed using chi-square tests. Gene-gene interactions were also evaluated following different methodological approaches. No significant results emerged after performing the appropriate statistical corrections. Our results seem to discard a relevant role of Th17 cells on CD risk.
Genome wide association, Multiple sclerosis, Crohns disease, Risk, Variants, Th17 cells, IL23R, Gliadin, Interleukin 23, Autoimmunity, Inflammation
Public Library of Science
Plos One, 2012, 7(2): e31244
Versión del editor
This work was supported by a grant from ‘‘Fondo de Investigaciones Sanitarias’’ (CP08/00213).