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    Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling

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    MBS-JOURNAL-S-15-00130.pdf (3.847Mb)
    Date
    2015
    Author
    Valle Turrillas, Jaione Upna
    Burgui Erice, Saioa Upna
    Langheinrich, Denise 
    Gil Puig, Carmen Upna
    Solano Goñi, Cristina Upna
    Toledo Arana, Alejandro Upna
    Helbig, Ralf 
    Lasagni, Andrés 
    Lasa Uzcudun, Íñigo Upna
    Version
    Acceso abierto / Sarbide irekia
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    Artículo / Artikulua
    Version
    Versión enviada / Bidali den bertsioa
    Project Identifier
    ES/6PN/AGL2011-23954 
    ES/6PN/BIO2011-30503 
    Impact
     
     
     
     
     
     
     
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    Abstract
    Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial attachment and biofilm development. However, fabrication of 27 functional biomaterials at large scale with periodic network-topology is still problematic. In this 28 study, we u ... [++]
    Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial attachment and biofilm development. However, fabrication of 27 functional biomaterials at large scale with periodic network-topology is still problematic. In this 28 study, we use direct laser interference (DLIP), an easily scalable process, to modify polystyrene 29 surface (PS) topography at sub-micrometer scale. The resulting structure surfaces were 30 interrogated for their capacity to prevent adhesion and biofilm formation of the major human 31 pathogen Staphylococcus aureus. The results revealed that three-dimensional micrometer 32 periodic structures on PS have a profound impact on bacterial adhesion capacity. Thus, line- 33 and pillar-like topographical patterns enhanced S. aureus adhesion, whereas complex lamella 34 microtopography reduced S. aureus adhesion both in static and continuous flow culture 35 conditions. Interestingly, lamella-like textured surfaces retained the capacity to inhibit S. aureus 36 adhesion both when the surface is coated with human serum proteins in vitro and when the 37 material is implanted subcutaneously in a foreign-body associated infection model. Our results 38 establish that the DLIP technology can be used to functionalize polymeric surfaces for the 39 inhibition of bacterial adhesion to surfaces. [--]
    Subject
    Bacterial adhesion, Biofilms, Staphylococcus aureus, Direct laser interference
     
    Description
    La versión final de este artículo fue publicada en Macromolecular Bioscience, 15: 1060–1069. DOI:10.1002/mabi.201500107
    Departament
    IdAB - Instituto de Agrobiotecnología / Agrobioteknologiako Institutua
    URI
    https://hdl.handle.net/2454/22611
    Sponsorship
    J. Valle was supported by Spanish Ministry of Science and Innovation “Ramón y Cajal” 369 contract. This research was supported by grants AGL2011-23954 and BIO2011-30503-C02-02 370 from the Spanish Ministry of Economy and Competitivity and IIQ14066.RI1 from Innovation 371 Department of the Government of Navarra.
    Appears in Collections
    • Artículos de revista - Aldizkari artikuluak [2160]
    • Artículos de revista IdAB - IdAB Aldizkari artikuluak [159]
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