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dc.creatorMuñoz, Marinaes_ES
dc.creatorCamargo, Milenaes_ES
dc.creatorSoto de León, Saraes_ES
dc.creatorSánchez, Ricardoes_ES
dc.creatorParra, Dianaes_ES
dc.creatorPineda Peña, Andreaes_ES
dc.creatorSussmann, Ottoes_ES
dc.creatorPérez Prados, Antonioes_ES
dc.creatorPatarroyo, Manuel Elkines_ES
dc.creatorPatarroyo, Manuel Alfonsoes_ES
dc.date.accessioned2017-02-10T09:41:41Z
dc.date.available2017-02-10T09:41:41Z
dc.date.issued2013
dc.identifier.issn1932-6203 (Electronic)
dc.identifier.urihttps://hdl.handle.net/2454/23537
dc.description.abstractInfection, coinfection and type-specific human papillomavirus (HPV) distribution was evaluated in human immunodeficiency virus (HIV)-positive women from paired cervical and urine samples. Paired cervical and urine samples (n = 204) were taken from HIV-positive women for identifying HPV-DNA presence by using polymerase chain reaction (PCR) with three generic primer sets (GP5+/6+, MY09/11 and pU1M/2R). HPV-positive samples were typed for six high-risk HPV (HR-HPV) (HPV-16, -18, -31, -33, -45 and -58) and two low-risk (LR-HPV) (HPV-6/11) types. Agreement between paired sample results and diagnostic performance was evaluated. HPV infection prevalence was 70.6% in cervical and 63.2% in urine samples. HPV-16 was the most prevalent HPV type in both types of sample (66.7% in cervical samples and 62.0% in urine) followed by HPV-31(47.2%) in cervical samples and HPV-58 (35.7%) in urine samples. There was 55.4% coinfection (infection by more than one type of HPV) in cervical samples and 40.2% in urine samples. Abnormal Papanicolau smears were observed in 25.3% of the women, presenting significant association with HPV-DNA being identified in urine samples. There was poor agreement of cervical and urine sample results in generic and type-specific detection of HPV. Urine samples provided the best diagnosis when taking cytological findings as reference. In conclusion including urine samples could be a good strategy for ensuring adherence to screening programs aimed at reducing the impact of cervical cancer, since this sample is easy to obtain and showed good diagnostic performance.en
dc.description.sponsorshipThis project was funded by the Basque Cooperation Agency Development and by the Spanish Agency for International Development Cooperation (AECID).en
dc.format.extent7 p.
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherPublic Library of Scienceen
dc.relation.ispartofPLoS ONE 8(2): e56509en
dc.rights© 2013 Muñoz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectHuman papillomavirus (HPV)en
dc.subjectHIVen
dc.subjectUrine samplesen
dc.subjectCervical samplesen
dc.titleHuman papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samplesen
dc.typeArtículo / Artikuluaes
dc.typeinfo:eu-repo/semantics/articleen
dc.contributor.departmentUniversidad Pública de Navarra. Departamento de Estadística e Investigación Operativaes_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Estatistika eta Ikerketa Operatiboa Sailaeu
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.identifier.doi10.1371/journal.pone.0056509
dc.relation.publisherversionhttps://dx.doi.org/10.1371/journal.pone.0056509
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen


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© 2013 Muñoz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as © 2013 Muñoz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.