Encapsulation of fluorinated nanoparticles as potential off/on probe for 19F MRI

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Fecha
2017Autor
Director
Versión
Acceso abierto / Sarbide irekia
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Trabajo Fin de Máster/Master Amaierako Lana
Impacto
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Resumen
The present work deals with the synthesis of fluorine labeled gold
nanoparticles followed by their encapsulation in gelatin nanoparticles. The
choice of gelatin is based on its role as substrate for gelatinases MMP
enzymes (MMP-2/9). Hence, our hypothesis is that when our fluorine labeled
NPs are encapsulated in gelatin the 19F MRI signal would be OFF. The
disassembly of the gelatin NPs trig ...
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The present work deals with the synthesis of fluorine labeled gold
nanoparticles followed by their encapsulation in gelatin nanoparticles. The
choice of gelatin is based on its role as substrate for gelatinases MMP
enzymes (MMP-2/9). Hence, our hypothesis is that when our fluorine labeled
NPs are encapsulated in gelatin the 19F MRI signal would be OFF. The
disassembly of the gelatin NPs triggered by its digestion by MMPs should
lead to the turning ON of the signal. [--]
Materias
Titulación
Máster Universitario en Química Sintética e Industrial por la Universidad de Valladolid; la Universidad del País Vasco/Euskal Herriko Unibertsitatea y la Universidad Pública de Navarra /
Unibertsitate Masterra Kimika Sintetikoan eta Industria Kimikan