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Lentinula edodes β-glucan enriched diet induces pro- and anti-inflammatory macrophages in rabbit
dc.creator | Crespo, Helena | es_ES |
dc.creator | Guillén, Hugo | es_ES |
dc.creator | Pablo Maiso, Lorena de | es_ES |
dc.creator | Gómez Arrebola, Carmen | es_ES |
dc.creator | Rodríguez, Gregorio | es_ES |
dc.creator | Glaría Ezquer, Idoia | es_ES |
dc.creator | Andrés Cara, Damián de | es_ES |
dc.creator | Reina Arias, Ramsés | es_ES |
dc.date.accessioned | 2018-09-04T06:43:45Z | |
dc.date.available | 2018-09-04T06:43:45Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1654-6628 (Print) | |
dc.identifier.issn | 1654-661X (Electronic) | |
dc.identifier.uri | https://hdl.handle.net/2454/30426 | |
dc.description.abstract | β-glucans exhibited in cell walls of several pathogens as bacteria or fungi are sensed by pathogen recognition receptors such as scavenger receptors present in antigen presenting cells, i.e., macrophages. β-glucans obtained from Shiitake mushrooms were chemically characterized. A β-glucan supplemented diet was assayed for 30 days in rabbits aiming to characterize the immune response elicited in blood-derived macrophages. M1 and M2 profiles of macrophage differentiation were confirmed in rabbits by in vitro stimulation with IFN-γ and IL-4 and marker quantification of each differentiation pathway. Blood derived macrophages from rabbits administered in vivo with the β-glucan supplemented diet showed higher IL-4, IFN-γ and RAGE together with lower IL-10 relative expression, indicative of an ongoing immune response. Differences in IL-1β, IL-13 and IL-4 expression were also found in rabbit sera by ELISA suggesting further stimulation of the adaptive response. Recent challenges in the rabbit industry include the search of diet supplements able to elicit an immune stimulation with particular interest in facing pathogens such as viruses or bacteria. β–glucans from fungi may contribute to maintain an immune steady state favouring protection and thus reducing antibiotic treatment. | en |
dc.description.sponsorship | This work was funded by MAGRAMA, IDi 2014 (REF.: 20140020001815), CDTI (Ref.: IDI 20140852) and ADER (Ref.: 2013-l-lDD-00074). Ramsés Reina was supported by Spanish Ministry of Science and Innovation ‘Ramón y Cajal’ contract. | en |
dc.format.extent | 8 p. | |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Taylor & Francis | en |
dc.relation.ispartof | Food & Nutrition Research, 2017 Vol. 61, 1412791 | en |
dc.rights | © 2017 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Fungal β-glucan | en |
dc.subject | Macrophages | en |
dc.subject | Polarization | en |
dc.subject | Rabbit | en |
dc.subject | Diet | en |
dc.title | Lentinula edodes β-glucan enriched diet induces pro- and anti-inflammatory macrophages in rabbit | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | Artículo / Artikulua | es |
dc.contributor.department | IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.identifier.doi | 10.1080/16546628.2017.1412791 | |
dc.relation.publisherversion | https://doi.org/10.1080/16546628.2017.1412791 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |