Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep
Fecha
2010Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Impacto
|
10.1051/vetres/2010030
Resumen
There are few reports on the pathogenesis of scrapie (Sc) and Visna/maedi virus (VMV)
coinfections. The aim of this work was to study in vivo as well as post mortem both diseases in 91 sheep.
Diagnosis of Sc and VMV infections allowed the distribution of animals into five groups according to the
presence (+) or absence ( ) of infection by Sc and VMV: Sc /VMV , Sc /VMV+, Sc+/VMV and Sc+/
VMV+. ...
[++]
There are few reports on the pathogenesis of scrapie (Sc) and Visna/maedi virus (VMV)
coinfections. The aim of this work was to study in vivo as well as post mortem both diseases in 91 sheep.
Diagnosis of Sc and VMV infections allowed the distribution of animals into five groups according to the
presence (+) or absence ( ) of infection by Sc and VMV: Sc /VMV , Sc /VMV+, Sc+/VMV and Sc+/
VMV+. The latter was divided into two subgroups, with and without VMV-induced lymphoid follicle
hyperplasia (LFH), respectively. In both the lung and mammary gland, PrPSc deposits were found in the
germinal center of hyperplasic lymphoid follicles in the subgroup of Sc+/VMV+ having VMV-induced LFH.
This detection was always associated with (and likely preceded by) PrPSc observation in the corresponding
lymph nodes. No PrPSc was found in other VMV-associated lesions. Animals suffering from scrapie had a
statistically significantly lower mean age than the scrapie free animals at the time of death, with no apparent
VMV influence. ARQ/ARQ genotype was the most abundant among the 91 ewes and the most frequent in
scrapie-affected sheep. VMV infection does not seem to influence the scrapie risk group distribution among
animals from the five groups established in this work. Altogether, these data indicate that certain VMVinduced
lesions can favor PrPSc deposits in Sc non-target organs such as the lung and the mammary gland,
making this coinfection an interesting field that warrants further research for a better comprehension of the
pathogenesis of both diseases. [--]
Materias
Visna/maedi,
Scrapie,
Sheep,
Coinfection
Editor
EDP Sciences
Publicado en
Veterinary Research, (2010) 41:58
Departamento
Universidad Pública de Navarra/Nafarroako Unibertsitate Publikoa. IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua
Versión del editor
Entidades Financiadoras
This work has been funded by a grant of Ministerio de Ciencia e Innovación (ref. AGL2007-66874-C04 GAN). E. Salazar was a PhD student funded by grant B073/2006 from Gobierno de Aragón.
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