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dc.creatorZubiate Orzanco, Pabloes_ES
dc.creatorUrrutia Azcona, Aitores_ES
dc.creatorRuiz Zamarreño, Carloses_ES
dc.creatorEgea Urra, Josunees_ES
dc.creatorFernández Irigoyen, Joaquínes_ES
dc.creatorGiannetti, Ambraes_ES
dc.creatorBaldini, Francescoes_ES
dc.creatorDíaz Lucas, Silviaes_ES
dc.creatorMatías Maestro, Ignacioes_ES
dc.creatorArregui San Martín, Francisco Javieres_ES
dc.creatorSantamaría, Enriquees_ES
dc.creatorChiavaioli, Francescoes_ES
dc.creatorDel Villar, Ignacioes_ES
dc.description.abstractD-dimer is a useful diagnostic biomarker for deep vein thrombosis or pulmonary embolism, collectively referred to as venous thromboembolism (VTE). The ability to detect in real-time the amount of D-dimer with a fast and reliable method is a key step to anticipate the appearance of these diseases. Here, the results of a highly specific and sensitive biosensor for the detection of D-dimer based on lossy mode resonance in fiber optics are presented. The unique features of specialty fibers in light management integrated with microfluidics allow detecting D-dimer in human serum with a detection limit of 100 ng/mL, a value 5-fold below the clinical cutoff value. Comparison of the results achieved with mass-spectrometry-based proteomics, which allows for the identification of beta- and gamma-chains of fibrinogen, demonstrates the ability of our platform to specifically (>90%) recognize D-dimer. Therefore, this technology potentially represents a paradigm shift in the development of a simple, high-specificity and label-free biosensing platform, which can be applied to speed up diagnostic healthcare processes of venous thromboembolism toward an early diagnostic and personalized treatment system.en
dc.description.sponsorshipThis work is funded by grants from the Spanish Agencia Estatal de Investigación (AEI) and European Regional Development Fund (FEDER) (TEC2016-78047-R) and the Department of Economic Development from Government of Navarra (REF. PC023-24-25 , PC081-082 , and PI031). The Proteomics Unit of Navarrabiomed is a member of Proteored, PRB3-ISCIII, and is supported by grant PT17/0019/009, of the PE I+D+I 2013–2016 funded by ISCIII and FEDER. This work is partly funded by the European Commission, Directorate-General Communications Networks, Content and Technology (DG CONNECT) under the ERA-NET Cofund scheme - Horizon 2020 'Horizon 2020 – the Framework Programme for Research and Innovation ( 2014–2020 )' for the project OPTIMO and by National Research Council of Italy (CNR) within the Short Term Mobility program (STM 2017 ).en
dc.format.extent10 p.
dc.relation.ispartofBiosensors and Bioelectronics: X 2 2019 100026en
dc.rights© 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.en
dc.subjectOptical biosensoren
dc.subjectLossy mode resonanceen
dc.subjectVenous thromboembolismen
dc.subjectNanocoated fiberen
dc.titleFiber-based early diagnosis of venous thromboembolic disease by label-free D-dimer detectionen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentUniversidad Pública de Navarra. Departamento de Ingeniería Eléctrica, Electrónica y de Comunicaciónes_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Ingeniaritza Elektriko, Elektroniko eta Telekomunikazio Sailaeu
dc.contributor.departmentUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa. ISC - Institute of Smart Citieses_ES
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernuaes

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© 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.
Except where otherwise noted, this item's license is described as © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.