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dc.creatorEnguita Germán, Mónicaes_ES
dc.creatorTamayo Rodríguez, Ibaies_ES
dc.creatorGalbete Jiménez, Arkaitzes_ES
dc.creatorLibrero, Juliánes_ES
dc.creatorCambra Contin, Koldoes_ES
dc.creatorIbáñez Beroiz, B.es_ES
dc.description.abstractCardiovascular disease (CVD) is the most common cause of morbidity and mortality among patients with type 2 diabetes (T2D). Physical activity (PA) is one of the few modifiable factors that can reduce this risk. The aim of this study was to estimate to what extent PA can contribute to reducing CVD risk and all-cause mortality in patients with T2D. Information from a population-based cohort including 26,587 patients with T2D from the Navarre Health System who were fol-lowed for five years was gathered from electronic clinical records. Multivariate Cox regression models were fitted to estimate the effect of PA on CVD risk and all-cause mortality, and the approach was complemented using conditional logistic regression models within a matched nested case–con-trol design. A total of 5111 (19.2%) patients died during follow-up, which corresponds to 37.8% of the inactive group, 23.9% of the partially active group and 12.4% of the active group. CVD events occurred in 2362 (8.9%) patients, which corresponds to 11.6%, 10.1% and 7.6% of these groups. Compared with patients in the inactive group, and after matching and adjusting for confounders, the OR of having a CVD event was 0.84 (95% CI: 0.66–1.07) for the partially active group and 0.71 (95% CI: 0.56–0.91) for the active group. A slightly more pronounced gradient was obtained when focused on all-cause mortality, with ORs equal to 0.72 (95% CI: 0.61–0.85) and 0.50 (95% CI: 0.42–0.59), respectively. This study provides further evidence that physically active patients with T2D may have a reduced risk of CVD-related complications and all-cause mortality.en
dc.description.sponsorshipFunding: this research was funded by the Instituto de Salud Carlos III, via grant PI15/02196 and via CONCEPT project (grants PI19/00154, PI19/00306, PI19/00381, PI19/00056 and PI20/00783). It also received funding from the Research Network on Health Services in Chronic Diseases (REDIS-SEC) grant RD16/0001/0014, a Spanish Network supported by Instituto de Salud Carlos III and the European Regional Development Funding (FEDER). All funds are public and had no role in the design of the study, the data integration and analysis or in the writing of the paper.en
dc.format.extent13 p.
dc.relation.ispartofInternational Journal of Environmental Research and Public Health, 18 (23)en
dc.rights© 2021 by the authors. Creative Commons Attribution 4.0 Internationalen
dc.subjectCardiovascular diseaseen
dc.subjectNested case-controlen
dc.subjectPhysical activityen
dc.subjectPopulation-based cohorten
dc.subjectType 2 diabetesen
dc.titleEffect of physical activity on cardiovascular event risk in a population-based cohort of patients with type 2 diabetesen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentEstadística, Informática y Matemáticases_ES
dc.contributor.departmentEstatistika, Informatika eta Matematikaeu
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.type.versionVersión publicada / Argitaratu den bertsioaes

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© 2021 by the authors. Creative Commons Attribution 4.0 International
Except where otherwise noted, this item's license is described as © 2021 by the authors. Creative Commons Attribution 4.0 International

El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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