Dpto. Química Aplicada - Kimika Aplikatua Saila
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Browsing Dpto. Química Aplicada - Kimika Aplikatua Saila by Author "Ancín Azpilicueta, Carmen"
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Publication Open Access Rosa canina extracts have antiproliferative and antioxidant effects on caco-2 human colon cancer(Public Library of Science, 2016) Jiménez Alonso, Sandra; Gascón, Sonia; Luquin, Asunción; Laguna, Mariano; Ancín Azpilicueta, Carmen; Rodríguez Yoldi, María Jesús; Química Aplicada; Kimika AplikatuaThe in vitro antiproliferative and antioxidant effects of different fractions of Rosa canina hips on human colon cancer cell lines (Caco-2) was studied. The compounds tested were total extract (fraction 1), vitamin C (fraction 2), neutral polyphenols (fraction 3) and acidic polyphenols (fraction 4). All the extracts showed high cytotoxicity after 72 h, both low and high concentrations. The flow cytometric analysis revealed that all the fractions produce disturbances in the cell cycle resulting in a concomitant cell death by an apoptotic pathway. Changes in the redox status of Caco-2 cells in response to Rosa canina hips were determined. Cells were exposed to hydrogen peroxide in presence of plant fractions and the production of Reactive Oxygen Species (ROS) was significantly decreased. Therefore, our data demonstrate that rosehip extracts are a powerful antioxidant that produces an antiproliferative effect in Caco-2 cells. Therefore, these results predict a promising future for Rosa canina as a therapeutic agent. Thus, this natural plant could be an effective component of functional foods addressed towards colorectal carcinoma.Publication Open Access Therapeutic applications of rose hips from different rosa species(MDPI, 2017) Mármol, Inés; Sánchez de Diego, Cristina; Jiménez Moreno, Nerea; Ancín Azpilicueta, Carmen; Rodríguez Yoldi, María Jesús; Química Aplicada; Kimika AplikatuaRosa species, rose hips, are widespread wild plants that have been traditionally used as medicinal compounds for the treatment of a wide variety of diseases. The therapeutic potential of these plants is based on its antioxidant effects caused by or associated with its phytochemical composition, which includes ascorbic acid, phenolic compounds and healthy fatty acids among others. Over the last few years, medicinal interest in rose hips has increased as a consequence of recent research that has studied its potential application as a treatment for several diseases including skin disorders, hepatotoxicity, renal disturbances, diarrhoea, inflammatory disorders, arthritis, diabetes, hyperlipidaemia, obesity and cancer. In this review, the role of different species of Rosa in the prevention of treatment of various disorders related to oxidative stress, is examined, focusing on new therapeutic approaches from a molecular point of view.