Browsing by Author "Arruebo Gordo, Manuel"
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Publication Open Access Gold nanoparticles capped with a novel titanium(iv)-containing polyoxomolybdate cluster: selective and enhanced bactericidal effect against Escherichia coli(Wiley, 2024) Paesa, Mónica; Almazán, Fernando; Yus Argón, Cristina; Sebastián, Víctor; Arruebo Gordo, Manuel; Gandía Pascual, Luis; Reinoso, Santiago; Pellejero, Ismael; Mendoza, Gracia; Ciencias; Zientziak; Institute for Advanced Materials and Mathematics - INAMAT2; Universidad Pública de Navarra / Nafarroako Unibertsitate PublikoaBacterial infections are a public health threat of increasing concern in medical care systems; hence, the search for novel strategies to lower the use of antibiotics and their harmful effects becomes imperative. Herein, the antimicrobial performance of four polyoxometalate (POM)-stabilized gold nanoparticles (Au@POM) against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as Gram-negative and Gram-positive bacteria models, respectively, is studied. The bactericidal studies performed, both in planktonic and sessile forms, evidence the antimicrobial potential of these hybrid nanostructures with selectivity toward Gram-negative species. In particular, the Au@GeMoTi composite with the novel [Ti2(HGeMo7O28)2]10¿ POM capping ligand exhibits outstanding bactericidal efficiency with a minimum inhibitory concentration of just 3.12 µm for the E. coli strain, thus outperforming the other three Au@POM counterparts. GeMoTi represents the fourth example of a water-soluble TiIV-containing polyoxomolybdate, and among them, the first sandwich-type structure having heteroatoms in high-oxidation state. The evaluation of the bactericidal mechanisms of action points to the cell membrane hyperpolarization, disruption, and subsequent nucleotide leakage and the low cytotoxicity exerted on five different cell lines at antimicrobial doses demonstrates the antibiotic-like character. These studies highlight the successful design and development of a new POM-based nanomaterial able to eradicate Gram-negative bacteria without damaging mammalian cells.Publication Open Access Síntesis de recubrimientos anti bacterianos de quitosano-oro sobre catéteres urinarios(2023) Pérez Salvador, Arnau; Arruebo Gordo, Manuel; Yus Argón, Cristina; Escuela Técnica Superior de Ingeniería Industrial, Informática y de Telecomunicación; Industria, Informatika eta Telekomunikazio Ingeniaritzako Goi Mailako Eskola TeknikoaEste trabajo de investigación pretende explorar el potencial de los recubrimientos basados en quitosano con nanopartículas de oro como una solución prometedora y eficaz para conferir propiedades bactericidas a los catéteres urinarios comerciales. El estudio se centrará en la evaluación de su actividad antimicrobiana, su estabilidad y su efectividad en la prevención de infecciones asociadas. Los hallazgos de este estudio podrían contribuir al avance de la nanotecnología en medicina y ofrecer nuevas estrategias para el diseño de dispositivos médicos más seguros y eficientes.