Person:
Jiménez Moreno, Nerea

Profile Picture

Email Address

person.page.identifierURI

https://academica-e.unavarra.es/handle/2454/49322

Birth Date

Research Projects

Organizational Units

Job Title

Last Name

Jiménez Moreno

First Name

Nerea

person.page.departamento

Ciencias

person.page.instituteName

InaMat2. Instituto de Investigación en Materiales Avanzados y Matemáticas

ORCID

0000-0002-8065-5220

person.page.upna

7765

Name

Filters

20201
Reset filters

Settings

Author: Cerrada, Elena × Subject: ROS ×

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    PublicationOpen Access
    A combination of Rosa canina extracts and gold complex favors apoptosis of Caco-2 cells by increasing oxidative stress and mitochondrial dysfunction
    (MDPI, 2020) Mármol, Inés; Jiménez Moreno, Nerea; Ancín Azpilicueta, Carmen; Osada, Jesús; Cerrada, Elena; Rodríguez Yoldi, María Jesús; Zientziak; Institute for Advanced Materials and Mathematics - INAMAT2; Ciencias
    Given the alarming increase in colorectal cancer (CRC) worldwide, novel therapies are urgently needed. Plant-derived extracts have gained considerable interest in the last years due to their strong anticancer effect mediated by their unique bioactive compounds. Specifically, rosehips from Rosa canina have been successfully tested against several cancer models, including colon cancer. Moreover, gold derivatives are a promising alternative to the current platinum-based drugs commonly used in CRC chemotherapy due to their lack of affinity for DNA. Herein we have investigated the antitumor potential of a drug combination made of acidic polyphenols extracted from R. canina and the gold complex (Au(C≡C-2-NC5H4) (PTA)) in Caco-2 cell line as a model of CRC. The combination triggered strong apoptosis mediated by a blockage of the autophagic flux, which might be a consequence of a reactive oxygen species (ROS) increase and mitochondrial dysfunctionality. Our results suggest that the clinical application of plant polyphenols might enhance the anticancer effect of metallodrugs and reduce drug exposure time and therefore its side effects.