Galarreta Rodríguez, Itziar
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Galarreta Rodríguez
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Itziar
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Ciencias
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InaMat2. Instituto de Investigación en Materiales Avanzados y Matemáticas
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Publication Open Access Fe3O4-SiO2 mesoporous core/shell nanoparticles for magnetic field-induced ibuprofen-controlled release(American Chemical Society, 2022-12-23) García Rodríguez, Lucía; Garayo Urabayen, Eneko; López Ortega, Alberto; Galarreta Rodríguez, Itziar; Cervera Gabalda, Laura María; Cruz Quesada, Guillermo; Cornejo Ibergallartu, Alfonso; Garrido Segovia, Julián José; Gómez Polo, Cristina; Pérez de Landazábal Berganzo, José Ignacio; Ciencias; Zientziak; Institute for Advanced Materials and Mathematics - INAMAT2; Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa, PJUPNA2020; Gobierno de Navarra / Nafarroako GobernuaHybrid magnetic nanoparticles made up of an iron oxide, Fe3O4, core and a mesoporous SiO2 shell with high magnetization and a large surface area were proposed as an efficient drug delivery platform. The core/shell structure was synthesized by two seed-mediated growth steps combining solvothermal and sol—gel approaches and using organic molecules as a porous scaffolding template. The system presents a mean particle diameter of 30(5) nm (9 nm magnetic core diameter and 10 nm silica shell thickness) with superparamagnetic behavior, saturation magnetization of 32 emu/g, and a significant AC magnetic-field-induced heating response (SAR = 63 W/gFe3O4, measured at an amplitude of 400 Oe and a frequency of 307 kHz). Using ibuprofen as a model drug, the specific surface area (231 m2/g) of the porous structure exhibits a high molecule loading capacity (10 wt %), and controlled drug release efficiency (67%) can be achieved using the external AC magnetic field for short time periods (5 min), showing faster and higher drug desorption compared to that of similar stimulus-responsive iron oxide-based nanocarriers. In addition, it is demonstrated that the magnetic field-induced drug release shows higher efficiency compared to that of the sustained release at fixed temperatures (47 and 53% for 37 and 42 °C, respectively), considering that the maximum temperature reached during the exposure to the magnetic field is well below (31 °C). Therefore, it can be hypothesized that short periods of exposure to the oscillating field induce much greater heating within the nanoparticles than in the external solution.Publication Open Access Nanoscale engineering of cobalt-gallium co-doped ferrites: a strategy to enhance high-frequency theranostic magnetic materials(American Chemical Society, 2025-07-01) Galarreta Rodríguez, Itziar; Liguori, Deborah; Garayo Urabayen, Eneko; Muzzi, Beatrice; Cervera Gabalda, Laura María; Rubio Zuazo, Juan; Gomide, Guilherme; Depeyrot, Jérõm; López Ortega, Alberto; Ciencias; Zientziak; Institute for Advanced Materials and Mathematics - INAMAT2; Universidad Publica de Navarra / Nafarroako Unibertsitate PublikoaThe nanoscale engineering of doped iron oxide magnetic nanoparticles has attracted significant interest in recent years for high-frequency theragnostic applications, where simultaneous diagnosis and therapy are required. In particular, their ability to generate localized heating under alternating magnetic fields makes them ideal candidates for magnetic hyperthermia, a noninvasive cancer treatment technique. However, understanding the complex interplay between multiple dopant cations and their impact on dynamic magnetic behavior remains a significant challenge. In this work, we present a comprehensive study on how two differently marked cations (Co2+ and Ga3+) can modify both the magnetic properties of these nanoparticles and their efficiency in heat generation under alternating magnetic fields. To this end, a series of nanoparticles with the formula CoxGa0.15Fe2.85-xO4 (0 < x < 0.3) was prepared via thermal decomposition, enabling the production of monodisperse nanocrystals with high crystallinity and precise stoichiometric control. Their exhaustive structural and magnetic characterization confirmed site-selective incorporation of Ga3+ into tetrahedral sites and Co2+ into octahedral sites. Increasing the cobalt content within the gallium-doped framework leads to enhanced magnetocrystalline anisotropy and higher saturation magnetization, both crucial parameters for efficient heat dissipation in magnetic hyperthermia. The study further demonstrates that the dynamic magnetic response of these nanostructures is strongly influenced by the interplay between doping composition, anisotropy, and the amplitude of the applied magnetic field. These findings highlight the effectiveness of nanoscale codoping strategies in fine-tuning magnetic behavior and optimizing the performance of spinel ferrite nanoparticles for advanced biomedical and technological applications, particularly high-frequency magnetic hyperthermia.