Open Access
Fiber-based label-free D-dimer detection for early diagnosis of venous thromboembolism
(SPIE, 2020) Zubiate Orzanco, Pablo; Urrutia Azcona, Aitor; Ruiz Zamarreño, Carlos; Fernández Irigoyen, Joaquín; Giannetti, Ambra; Baldini, Francesco; Díaz Lucas, Silvia; Matías Maestro, Ignacio; Arregui San Martín, Francisco Javier; Santamaría Martínez, Enrique; Del Villar, Ignacio; Chiavaioli, Francesco; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Institute of Smart Cities - ISC; Ingeniería Eléctrica, Electrónica y de Comunicación
D-dimer is a useful diagnostic biomarker for deep vein thrombosis or pulmonary embolism, collectively referred to as venous thromboembolism (VTE). The ability to detect in real-time the amount of D-dimer with a fast and reliable method is a key step to anticipate the appearance of these diseases. The combination of fiber-optic-based platforms for biosensing with the nanotechnologies is opening up the chance for the development of in situ, portable, lightweight, versatile, reliable and high-performance optical sensing devices towards lab-on-fiber technology. The generation of lossy mode resonances (LMRs) by means of the deposition of nm-thick absorbing metal-oxide films on special geometric-modified fibers allows measuring precisely and accurately surface refractive index changes, which are due to the binding interaction between a biological recognition element and the analyte under investigation. This approach enhances the light-matter interaction in a strong way, thus turning out to be more sensitive compared to other optical technology platforms, such as fiber gratings or surface plasmon resonance. Here, the results of a highly specific and sensitive biosensor for the detection of D-dimer based on LMR in fiber-optics are presented by monitoring in real-time the shift of the LMR related to the biomolecule interactions thanks to a conventional wavelength-interrogation system and an ad-hoc developed microfluidics. A detection limit of 100 ng/mL, a value 5-fold below the clinical cutoff value, has been attained for D-dimer spiked in human serum. The comparison of the results achieved with proteomics-based methodologies, which allows for the identification of betaand gamma-chains of fibrinogen, demonstrates the ability of our platform to specifically (>90%) recognize D-dimer.
Open Access
Initiative to increment the number of women in STEM degrees: women, science and technology chair of the Public University of Navarre
(IEEE, 2020) Aranguren Garacochea, Patricia; San Martín Biurrun, Idoia; Catalán Ros, Leyre; Martínez Ramírez, Alicia; Jurío Munárriz, Aránzazu; Díaz Lucas, Silvia; Pérez Artieda, Miren Gurutze; Gómez Fernández, Marisol; Barrenechea Tartas, Edurne; Estadística, Informática y Matemáticas; Ingeniería; Ingeniería Eléctrica, Electrónica y de Comunicación; Estatistika, Informatika eta Matematika; Ingeniaritza; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Gobierno de Navarra / Nafarroako Gobernua; Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
The Public University of Navarre joined with Navarre Government has created the Women, Science and Technology Chair. This chair arises due to the plummeting tendency of the percentage of women in STEM degrees with the aim of reversing this trend. The programme of activities is defined throughout this contribution by six activities: a Theatre Play, a Poster Award on Final Degree/Masters Project, The 1st Week of Women, Science and Technology, the Promotion of Technical Degrees in schools and high-schools, a Workshop about Gender Stereotypes and the Fostering of Women among Science and Environment. Each activity gained great success and the preset goals were highly accomplished, especially, the 1st Week of Women, Science and Technology activity. The latter achieved a great success both in participation and in repercussion, contributing to visualize the role of women in science and technology.
Open Access
46-km-long Raman amplified hybrid double-bus network with point and distributed Brillouin sensors
(IEEE, 2012) Fernández Vallejo, Montserrat; Olier Aguado, David; Zornoza Indart, Ander; Pérez Herrera, Rosa Ana; Díaz Lucas, Silvia; Elosúa Aguado, César; Bariáin Aisa, Cándido; Loayssa Lara, Alayn; López-Amo Sáinz, Manuel; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta Elektronikoa
We experimentally demonstrate a 46-km hybrid network that combine point and distributed Brillouin sensors. The proposed sensor network multiplexes low-cost intensity point sensors based on fiber-optic tapers, which are able to measure vibrations in the 0.01 to 50 Hz frequency range. The sensor network with a double-bus is a low noise configuration, which offers a higher optical signal to noise ratio and dynamic range than a single-bus. Thus, the number of sensors to be multiplexed could increase or we could reach further distances. The system also deploys remote distributed Raman amplification to extend the sensing range.
Open Access
All fiber interferometer for ice detection
(Optica Publishing Group, 2018) Arozarena Arana, Jesús Antonio; Socorro Leránoz, Abián Bentor; Del Villar, Ignacio; Díaz Lucas, Silvia; Matías Maestro, Ignacio; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta Elektronikoa; Institute of Smart Cities - ISC
This work presents an etched single-mode - multimode - single-mode structure that detects the solid-to-liquid change of state of the water due to an increased refractive index sensitivity within the 1.308 - 1.321 RIU range
Open Access
Single-mode-multimode-single-mode fiber (SMS): exploring environmental sensing capabilities
(IEEE, 2024-08-16) Díaz Lucas, Silvia; Armendáriz Ballesteros, Mikel; Matías Maestro, Ignacio; Ingeniería Eléctrica, Electrónica y de Comunicación; Ingeniaritza Elektrikoa, Elektronikoa eta Telekomunikazio Ingeniaritza; Institute of Smart Cities - ISC
In this paper, we study the environmental sensing capabilities of a Single-Mode-Multimode-Single-Mode (SMS) fiber in a simple low-cost configuration. SMS fibers exhibit sensitivity to temperature, humidity, refractive index and strain, making them suitable for numerous applications in telecommunications, environmental monitoring, and more. Experimental results demonstrate that the sensor achieves a maximum temperature sensitivity of 4.53 nm/°C. Additionally, SMS fibers can also work as humidity sensors by absorbing or releasing moisture, leading to variations in the refractive index. Monitoring these changes allows for precise humidity measurements, with a sensitivity of 0.1548 nm/%RH. Moreover, SMS fibers show a refractive index sensitivity of 39.65 nm/RIU and strain sensitivities as high as 1.062 nm/¿¿, indicating good performance.
Open Access
Sensitivity enhancement in low cutoff wavelength long-period fiber gratings by cladding diameter reduction
(MDPI, 2017) Del Villar, Ignacio; Partridge, Matthew; Rodríguez Rodríguez, Wenceslao Eduardo; Fuentes Lorenzo, Omar; Socorro Leránoz, Abián Bentor; Díaz Lucas, Silvia; Corres Sanz, Jesús María; James, Stephen; Tatam, Ralph; Ingeniaritza Elektrikoa eta Elektronikoa; Institute of Smart Cities - ISC; Ingeniería Eléctrica y Electrónica; Gobierno de Navarra / Nafarroako Gobernua: 2017/PI044
The diameter of long-period fiber gratings (LPFGs) fabricated in optical fibers with a low cutoff wavelength was be reduced by hydrofluoric acid etching, enhancing the sensitivity to refractive index by more than a factor of 3, to 2611 nm/refractive index unit in the range from 1.333 to 1.4278. The grating period selected for the LPFGs allowed access to the dispersion turning point at wavelengths close to the visible range of the optical spectrum, where optical equipment is less expensive. As an example of an application, a pH sensor based on the deposition of a polymeric coating was analyzed in two situations: with an LPFG without diameter reduction and with an LPFG with diameter reduction. Again, a sensitivity increase of a factor of near 3 was obtained, demonstrating the ability of this method to enhance the sensitivity of thin-film-coated LPFG chemical sensors.
Open Access
Vector-based pattern recognition algorithm for interferometric fiber sensor-signals analysis
(IEEE, 2025-01-15) Valentín-Coronado, Luis M.; Martínez Manuel, Rodolfo; Esquivel-Hernández, Jonathan; Díaz Lucas, Silvia; Martínez-Guerrero, María de Los Ángeles; Armendáriz Armenteros, Miguel Ángel; LaRochelle, Sophie; Institute of Smart Cities - ISC
A vector-based pattern recognition algorithm (V-PRA) for interferometric fiber sensor (IFS) signals is introduced. The proposed V-PRA transforms sensed interferometric signals into vectors to identify them by calculating the angular similarity with reference database vectors. This process accurately recognizes sensing patterns and assigns corresponding physical parameter values. The algorithm’s performance was tested in various IFS systems, including Fabry-Perot interferometers for refractive index measurement, multimode IFS for bending and strain monitoring, and multicore IFS for temperature monitoring. Experimental results confirm the effectiveness of the V-PRA as a specialized tool for IFSs.
Open Access
Optical system based on multiplexed FBGs to monitor hand movements
(IEEE, 2021) Socorro Leránoz, Abián Bentor; Díaz Lucas, Silvia; Castillo, Silvia; Dreyer, Uilian José; Martelli, Cicero; Cardozo da Silva, Jean Carlos; Uzqueda Esteban, Itziar; Gómez Fernández, Marisol; Ruiz Zamarreño, Carlos; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Estatistika, Informatika eta Matematika; Institute of Smart Cities - ISC; Institute for Advanced Materials and Mathematics - INAMAT2; Ingeniería Eléctrica, Electrónica y de Comunicación; Estadística, Informática y Matemáticas; Gobierno de Navarra / Nafarroako Gobernua
This contribution reports the development and characterization of an optical system based on parallel Fiber Bragg Gratings (FBGs) to monitor the movements of the wrist and fingers of a hand. The system consisted of a reflective configuration made of FBGs detecting the movements of the fingers and one more located on the wrist as a reference. All FBGs were multiplexed in order to collect the basic movements of the hand. Fibers were embedded in polydimethylsiloxane for protection and to give flexibility to the optical detection setup. Measurements of strain, angle and torsion were performed during the experiments, obtaining sensitivities up to 1.29 pm/ \mu \varepsilon in strain and 64.23 pm/° in angle. Also, a study on the influence of a single sensor on the performance of the whole system was analyzed for a complete study of this proof of concept. The obtained results present a simple system that can be used to monitor the positions of the hand or for the rehabilitation of patients suffering from neuromotor or post-stroke diseases.
Open Access
Multimode – coreless – multimode fiber-based sensors: theoretical and experimental study
(IEEE, 2019) San Fabián García, Noé; Socorro Leránoz, Abián Bentor; Del Villar, Ignacio; Díaz Lucas, Silvia; Matías Maestro, Ignacio; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Institute of Smart Cities - ISC; Ingeniería Eléctrica, Electrónica y de Comunicación
This paper presents a complete study on the spectral behavior of a multimode-coreless-multimode fiber-optic structure, as well as its application as a refractometer and a liquid level sensor. The combination of two standard multimode fibers fused to a coreless fiber segment allows generating narrow interferometric bands in the optical spectrum, whose sensitivity can be improved by an adequate selection of the dimensions of the device (the coreless segment length and the diameter of the sensing area). A second way to improve the performance of the device is to deposit a thin film of SnO2, which allows increasing the sensitivity up to 314 nm/RIU. This widens the number of applications where this structure can be used. As an example, a liquid level sensor with 0.73 nm/mm sensitivity is presented.
Open Access
Resilient amplified double ring optical networks to multiplex optical fibre sensors
(IEEE / OSA, 2009) Fernández Vallejo, Montserrat; Pérez Herrera, Rosa Ana; Elosúa Aguado, César; Díaz Lucas, Silvia; Urquhart, Paul; Bariáin Aisa, Cándido; López-Amo Sáinz, Manuel; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta Elektronikoa
We report the experimental demonstration of two configurations of an amplified optical fibre double ring network for the multiplexing of sensors. The networks are designed to be inherently resilient to fibre failures because they enable simultaneous interrogation of all the optical fibre sensors using both rings. The first design demonstrates the feasibility of the so called 'dedicated protection' and the second one 'shared protection' for fibre optic intensity sensors. Raman amplification is used to overcome the losses of the couplers used in the rings, providing power transparency. The first network uses Raman amplification in both constituent rings but in the second one Raman pumping is activated only when a fibre failure occurs. We demonstrate how the topology allows the received powers from the sensors to be equalized.