(American Society for Biochemistry and Molecular Biology, 2012-02-06) Teijido Hermida, Óscar; Ujwal, Rachna; Hillerdal, Carl-Olof; Kullman, Lisen; Rostovtseva, Tatiana K.; Abramson, Jeff; Ciencias de la Salud; Osasun Zientziak
Our study was focused entirely on the properties of
VDAC from the mitochondrial outer membrane; therefore, discussion
of possible VDAC N-terminal exposure on the plasma membrane
surface is totally irrelevant to this work. Our experiments did
not aim to test the position of the VDAC1Nterminus in the channel¿s
closed conformation. We cannot rule out the possibility that, when
closed, the first amino acids of the VDAC N terminus could be
exposed at the channel entrance, but these speculations are beyond
our present study.
