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Marzo Pérez, Florencio

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Marzo Pérez

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Florencio

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Ciencias del Medio Natural

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0000-0001-6428-9382

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18

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2006 - 200912020 - 20221
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Author: Barrenetxe, Jaione × End date: 2024 ×

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Now showing 1 - 2 of 2
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    PublicationOpen Access
    Effect of dietary quercetin and sphingomyelin on intestinal nutrient absorption and animal growth
    (Cambridge University Press, 2006) Barrenetxe, Jaione; Aranguren Garacochea, Patricia; Grijalba, A.; Martínez-Peñuela, J. M.; Marzo Pérez, Florencio; Urdaneta, Elena; Ciencias del Medio Natural; Natura Ingurunearen Zientziak
    Research on cancer and other conditions has shown flavonoids and sphingolipids to be food components capable of exerting chemoprotective action. Nevertheless, little is known about their effects on healthy individuals and their potential usefulness as therapeutic agents. The present study examined the possible action of a dietary flavonoid, quercetin, and a sphingolipid, sphingomyelin, as functional foods in healthy animals. In particular, the effect on animal growth of supplementing a conventional diet with one or other of these substances (0·5% quercetin and 0·05% sphingomyelin) was considered. Possible action affecting intestinal physiology was also analysed by measuring the uptake of sugar and dipeptide, mediated by the Na+-dependent sugar transporter SGLT1 and the dipeptide Na+/H+ exchanger PEPT1 respectively, and the activity of related intestinal enzymes such as sucrase, maltase and aminopeptidase N. Both substances seemed to modify small intestinal activity in healthy mice, altering intestinal enzymatic activity and nutrient uptake. These effects observed in the small intestine did not impair normal development of the animals, as no differences in serum biochemical parameters or in organ and body weights were found. The findings should help in elucidating the mechanisms of action of these food components with a view to their possible use in the prevention of certain pathological conditions.
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    PublicationOpen Access
    Effect of a diet supplemented with sphingomyelin and probiotics on colon cancer development in mice
    (Springer, 2022) Marzo Pérez, Florencio; Jauregui, Patricia; Barrenetxe, Jaione; Martínez-Peñuela, Ana; Ibáñez Moya, Francisco C.; Milagro, F. I.; Ciencias; Zientziak; Agronomía, Biotecnología y Alimentación; Agronomia, Bioteknologia eta Elikadura; Gobierno de Navarra / Nafarroako Gobernua
    Previous studies have reported that dietary sphingomyelin could inhibit early stages of colon cancer. Lactic acid–producing bacteria have also been associated with an amelioration of cancer symptoms. However, little is known about the potential beneficial effects of the combined administration of both sphingomyelin and lactic acid–producing bacteria. This article analyzes the effect of a diet supplemented with a combination of the probiotics Lacticaseibacillus casei and Bifidobacterium bifidum (108 CFU/ml) and sphingomyelin (0.05%) on mice with 1,2-dimethylhydrazine (DMH)-induced colon cancer. Thirty-six BALB/c mice were divided into 3 groups: one healthy group (group C) and two groups with DMH-induced cancer, one fed a standard diet (group D) and the other fed a diet supplemented with sphingomyelin and probiotics (DS). The number of aberrant crypt foci, marker of colon cancer development, was lower in the DS. The dietary supplementation with the synbiotic reversed the cancer-induced impairment of galactose uptake in enterocyte brush–border–membrane vesicles. These results confirm the beneficial effects of the synbiotic on the intestinal physiology of colon cancer mice and contribute to the understanding of the possible mechanisms involved.