(BMJ, 2023) Tamayo Rodríguez, Ibai; Librero, Julián; Galbete Jiménez, Arkaitz; Cambra Contin, Koldo; Enguita Germán, Mónica; Forga, Lluís; Goñi, María José; Lecea, Óscar; Gorricho Mendívil, Javier; Olazarán Santesteban, Álvaro; Arnedo Ajona, Laura; Moreno Iribas, Conchi; Lafita, Javier; Ibáñez Beroiz, Berta; Ciencias de la Salud; Osasun Zientziak; Estadística, Informática y Matemáticas; Estatistika, Informatika eta Matematika; Gestión de Empresas; Enpresen Kudeaketa
Purpose The CArdiovascular Risk in patients with
DIAbetes in Navarra (CARDIANA cohort) cohort was
established to assess the effects of sociodemographic and
clinical variables on the risk of cardiovascular events in
patients with type 1 (T1D) or type 2 (T2D) diabetes, with
a special focus on socioeconomic factors, and to validate
and develop cardiovascular risk models for these patients.
Participants The CARDIANA cohort included all patients
with T1D and T2D diabetes registered in the Public Health
Service of Navarra with prevalent disease on 1 January
2012. It consisted of 1067 patients with T1D (ages 2–88
years) and 33842 patients with T2D (ages 20–105 years),
whose data were retrospectively extracted from the Health
and Administrative System Databases.
Findings to date The follow-up period for wave 1 was
from 1 January 2012 to 31 December 2016. During these
5 years, 9 patients (0.8%; 95%CI (0.4% to 1.6%)) in the
T1D cohort developed a cardiovascular disease event,
whereas for the T2D cohort, 2602 (7.7%; 95%CI (7.4% to
8.0%)) had an event. For the T2D cohort, physical activity
was associated with a reduced risk of cardiovascular
events, with adjusted estimated ORs equal to 0.84 (95%
CI 0.66 to 1.07) for the partially active group and 0.71
(95% CI 0.56 to 0.91) for the active group, compared with
patients in the non-active group.
Future plans The CARDIANA cohort is currently being
used to assess the effect of sociodemographic risk
factors on CV risk at 5 years and to externally validate
cardiovascular predictive models. A second wave is
being conducted in late 2022 and early 2023, to extend
the follow-up other 5 years, from 1 January 2016 to 31
December 2021. Periodic data extractions are planned
every 5 years.
