Mendizábal Aizpuru, José Antonio

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https://academica-e.unavarra.es/handle/2454/49568

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Mendizábal Aizpuru

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José Antonio

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Agronomía, Biotecnología y Alimentación

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IS-FOOD. Research Institute on Innovation & Sustainable Development in Food Chain

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0000-0003-1316-4293

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88374

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231

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Subject: Adipocytes ×

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Now showing 1 - 3 of 3
  • Thumbnail Image
    PublicationOpen Access
    Size and number variation of adipocytes during the growth of Rasa Aragonesa lambs
    (CIHEAM, 1995) Purroy Unanua, Antonio; Mendizábal Aizpuru, José Antonio; Soret Lafraya, Beatriz; Horcada, Alberto; Lizaso, G.; Mendizábal Múgica, Francisco Javier; Arana Navarro, Ana; Producción Agraria; Nekazaritza Ekoizpena
    The size and number of adipocytes of different fat depots was studied in 45 male lambs of the Rasa Aragonesa breed, distributed in three groups of 15 lambs (G12, G24, G36), slaughtered respectively at 11.7 ± 0.67,24.5 ± 0.57 and 35.8 ± 1.74 kg live weight (LW) and at an age of 32 ± 5, 89 ± 8 and 123 ± 8 days. G12 lambs were slaughtered on the day of weaning, G24 and G36 lambs were weaned respectively at 16.2 ± 1.32 and 18.3 ± 2.46 kg LW and were fed from then onwards on concentrated fodder and barley straw ad libitum until they were slaughtered. The results obtained show that there is a significant increase in the amount of fat deposited in three internal (omental, mesenteric and kidney knob and channel) fat depots as the LW at slaughter increases (P<0.01). A similar phenomenon occurs in the size of the adipocytes, hypertrophy being more evident between 24 and 36 kg (P<0.01) than between 12 and 24 kg, except in the intermuscular fat depot, where the differences were between the two most extreme weight(P <0.01). The number of adipocytes in the omental and mesenteric fat depots increased significantly during the period of the study (P<0.01) while no variation occurred in the kidney knob and channel fat depot during the same period.
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    PublicationOpen Access
    Adipose tissue modification through feeding strategies and their implication on adipogenesis and adipose tissue metabolism in ruminants
    (MDPI, 2020) Urrutia Vera, Olaia; Mendizábal Aizpuru, José Antonio; Alfonso Ruiz, Leopoldo; Soret Lafraya, Beatriz; Insausti Barrenetxea, Kizkitza; Arana Navarro, Ana; Agronomia, Bioteknologia eta Elikadura; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD; Agronomía, Biotecnología y Alimentación; Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
    Dietary recommendations by health authorities have been advising of the importance of diminishing saturated fatty acids (SFA) consumption and replacing them by polyunsaturated fatty acids (PUFA), particularly omega-3. Therefore, there have been efforts to enhance food fatty acid profiles, helping them to meet human nutritional recommendations. Ruminant meat is the major dietary conjugated linoleic acid (CLA) source, but it also contains SFA at relatively high proportions, deriving from ruminal biohydrogenation of PUFA. Additionally, lipid metabolism in ruminants may differ from other species. Recent research has aimed to modify the fatty acid profile of meat, and other animal products. This review summarizes dietary strategies based on the n-3 PUFA supplementation of ruminant diets and their effects on meat fatty acid composition. Additionally, the role of n-3 PUFA in adipose tissue (AT) development and in the expression of key genes involved in adipogenesis and lipid metabolism is discussed. It has been demonstrated that linseed supplementation leads to an increase in alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA), but not in docosahexaenoic acid (DHA), whilst fish oil and algae increase DHA content. Dietary PUFA can alter AT adiposity and modulate lipid metabolism genes expression, although further research is required to clarify the underlying mechanism.
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    PublicationOpen Access
    Variación de la actividad lipogénica en cabras de raza Blanca Celtibérica según su estado corporal
    (Sociedad Española de Ovinotecnia y Caprinotecnia, 2001) Mendizábal Aizpuru, José Antonio; Delfa, R.; Eguinoa Ancho, Paola; Arana Navarro, Ana; González, C.; Alzón, M.; Purroy Unanua, Antonio; Producción Agraria; Nekazaritza Ekoizpena
    En 22 cabras adultas, secas y vacías, de raza Blanca Celtibérica con notas de condición corporal esternal comprendidas entre 1,5 y 4,5, se ha estudiado la variación de la cantidad de grasa, del tamaño y número de adipocitos, y de la actividad de las enzimas lipogénicas Glicerol 3P deshidrogenasa (G3PDH) y Sintetasa de ácidos grasos (FAS) en los depósitos grasos omental (OM), mesentérico (MES), pelvicorrenal (PVR), subcutáneo (SC) e intermuscular (IM) con la nota de condición corporal. Los resultados obtenidos muestran que el depósito graso SC es el que sufre un proceso de acumulación-movilización más intenso, seguido del OM, PVR, MES e IM, en este orden. El tamaño de los adipocitos varió en el mismo sentido que la cantidad de grasa, no observándose, en general, modificaciones en el número de adipocitos al variar la nota de condición corporal. Por último, la actividad de las enzimas G3PDH y FAS no se vió influenciada por la nCC.