Open Access
Nutritional modulation of the gut-brain axis: a comprehensive review of dietary interventions in depression and anxiety management
(MDPI, 2024-10-14) Merino del Portillo, Mariana ; Clemente Suárez, Vicente Javier; Ruisoto Palomera, Pablo; Jiménez, Manuel; Ramos Campo, Domingo Jesús; Beltrán Velasco, Ana Isabel; Martínez-Guardado, Ismael; Rubio-Zarapuz, Alejandro ; Navarro Jiménez, Eduardo; Tornero Aguilera, José Francisco; Ciencias de la Salud; Osasun Zientziak
Mental health is an increasing topic of focus since more than 500 million people in the world suffer from depression and anxiety. In this multifactorial disorder, parameters such as inflammation, the state of the microbiota and, therefore, the patient’s nutrition are receiving more attention. In addition, food products are the source of many essential ingredients involved in the regulation of mental processes, including amino acids, neurotransmitters, vitamins, and others. For this reason, this narrative review was carried out with the aim of analyzing the role of nutrition in depression and anxiety disorders. To reach the review aim, a critical review was conducted utilizing both primary sources, such as scientific publications and secondary sources, such as bibliographic indexes, web pages, and databases. The search was conducted in PsychINFO, MedLine (Pubmed), Cochrane (Wiley), Embase, and CinAhl. The results show a direct relationship between what we eat and the state of our nervous system. The gut–brain axis is a complex system in which the intestinal microbiota communicates directly with our nervous system and provides it with neurotransmitters for its proper functioning. An imbalance in our microbiota due to poor nutrition will cause an inflammatory response that, if sustained over time and together with other factors, can lead to disorders such as anxiety and depression. Changes in the functions of the microbiota–gut–brain axis have been linked to several mental disorders. It is believed that the modulation of the microbiome composition may be an effective strategy for a new treatment of these disorders. Modifications in nutritional behaviors and the use of ergogenic components are presented as important non-pharmacological interventions in anxiety and depression prevention and treatment. It is desirable that the choice of nutritional and probiotic treatment in individual patients be based on the results of appropriate biochemical and microbiological tests.
Open Access
The impact of the covid-19 pandemic on mental disorders. A critical review
(MDPI, 2021) Clemente Suárez, Vicente Javier; Martínez-González, Marina Begoña; Benítez Agudelo, Juan Camilo; Navarro Jiménez, Eduardo; Beltrán Velasco, Ana Isabel; Ruisoto Palomera, Pablo; Díaz Arroyo, Esperanza; Laborde Cárdenas, Carmen Cecilia; Tornero Aguilera, José Francisco; Ciencias de la Salud; Osasun Zientziak
The COVID-19 pandemic has impacted the lives of the worldwide population. Citizens suffer the social, economic, physiological, and psychological effects of this pandemic. Primary sources, scientific articles, and secondary bibliographic indexes, databases, and web pages were used for a consensus critical review. The method was a narrative review of the available literature to summarize the existing literature addressing mental health concerns and stressors related to the COVID-19 pandemic. The main search engines used in the present research were PubMed, SciELO, and Google Scholar. We found the pandemic has had a direct impact on psychopathologies such as anxiety, increasing its ratios, and depression. Other syndromes such as burnout and post-traumatic stress disorder have increased with the pandemic, showing a larger incidence among medical personnel. Moreover, eating disorders and violence have also increased. Public authorities must prepare healthcare systems for increasing incidences of mental pathologies. Mental health apps are one of the tools that can be used to reach the general population.
Open Access
Transdiagnostic model of psychological factors and sex differences in depression in a large sample of Ecuador
(Asociación Española de Psicología Conductual, 2022) Ruisoto Palomera, Pablo; López Guerra, Victor Manuel; López Núñez, Carla; Paladines Costa, María Belén; Sánchez Puertas, Rafael; Pineda Cabrera, Nairoby Jackeline; Ciencias de la Salud; Osasun Zientziak
Background/Objective: depression represents a leading cause of disability and a major contributor to the overall global burden of disease with women systematically reporting a higher prevalence than men. This study aimed to examine the predictive value and relation of three transdiagnostic psychological factors (perceived stress, psychological inflexibility and loneliness) on depression and its sex differences for the general population in a large sample of Ecuador. Method: a non-probabilistic and non-clinical sample of 16.074 people from across Ecuador were online surveyed using a cross-sectional design. The structural equation model was based on scores from standardized questionnaires as measures of depression, psychological perceived stress, psychological inflexibility, and loneliness. Results: women reported significantly higher levels of depression, mediated by differences in perceived stress, psychological inflexibility and loneliness. Perceived stress was the most important predictor of depression and mediated the effect of loneliness on depression. Complementarily, psychological inflexibility partially mediated the effect of perceived stress and loneliness on depression. The overall model accounted for the 78% of the total variance in depression. Conclusions: results of this study provide a novel and robust transdiagnostic model of sex differences on depression and insights on how to design effective programs for preventing depression targeting modifiable transdiagnostic risk factors.

Ruisoto Palomera, Pablo

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