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Martínez Labari, Cristina

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Martínez Labari

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Cristina

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Ciencias de la Salud

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0009-0007-7055-7604

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811181

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Author: Ibáñez Santos, Javier ×

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    PublicationOpen Access
    The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training
    (Oxford University Press, 2009) Fernández-Real, Jose Manuel; Izquierdo Redín, Mikel; Ortega, Francisco B.; Gorostiaga Ayestarán, Esteban; Gómez-Ambrosi, Javier; Moreno-Navarrete, Jose María; Frühbeck, Gema; Martínez Labari, Cristina; Idoate, Fernando; Salvador, Javier; Forga, Lluís; Ricart, Wifredo; Ibáñez Santos, Javier; Ciencias de la Salud; Osasun Zientziak
    Context: Bone has recently been described as exhibiting properties of an endocrine organ by producing osteocalcin that increases insulin sensitivity and secretion in animal models. Objective and Design: We aimed to evaluate circulating osteocalcin in association with insulin sensitivity and insulin secretion in three different studies in nondiabetic subjects: one cross-sectional study in 149 men (using minimal model), and two longitudinal studies in two independent groups (one formed by 26 women, and the other by 9 men and 11 women), after a mean of 7.3 and 16.8% weight loss, and after a mean of 8.7% weight loss plus regular exercise. Results: In the cross-sectional study, circulating osteocalcin was associated with insulin sensitivity, mainly in lean subjects, and with insulin secretion (only in lean subjects). A mean of 16.8%, but not 7.3% weight loss, led to significant increases in circulating osteocalcin. However, a mean of 8.7% weight loss plus regular exercise led to the more pronounced effects on the serum osteocalcin concentration, which increased in parallel to reduced visceral fat mass, unchanged thigh muscle mass, and increased leg strength and force. The postintervention serum levels of osteocalcin were associated with both insulin sensitivity (r = 0.49; P = 0.03) and fasting triglycerides (r = −0.54; P = 0.01). The change in visceral fat was the parameter that best predicted the change in serum osteocalcin, once age, body mass index, and insulin sensitivity changes were controlled for (P = 0.002). Conclusion: Circulating osteocalcin could mediate the role of bone as an endocrine organ in humans.
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    PublicationOpen Access
    Circulating soluble transferrin receptor concentration decreases after exercise-induced improvement of insulin sensitivity in obese individuals
    (Springer Nature, 2009) Fernández-Real, Jose Manuel; Izquierdo Redín, Mikel; Moreno-Navarrete, Jose María; Gorostiaga Ayestarán, Esteban; Ortega, Francisco B.; Martínez Labari, Cristina; Idoate, Fernando; Ricart, Wifredo; Ibáñez Santos, Javier; Ciencias de la Salud; Osasun Zientziak
    Background: Circulating soluble transferrin receptor (sTfR) has been recently found to be associated negatively with insulin sensitivity. Objective: To evaluate circulating sTfR concentration after changing insulin sensitivity in obese individuals. Design: Circulating sTfR concentration was evaluated after diet-induced weight loss in obese women (diet (D) group, n=8); after diet-induced weight loss plus resistance training (D+RT group, n=11); and after follow-up without weight loss (control (C) group, n=7). Results: After 16 weeks, insulin sensitivity (HOMA (Homeostasis Model Assessment) value) significantly improved in parallel to weight loss (−7.3%) and reduced total fat mass (evaluated using magnetic resonance imaging) in the D group. Thigh muscle mass decreased significantly (P=0.03). Serum sTfR concentration did not change significantly. In the D+RT group, weight loss (−8.7%) and improvement of insulin sensitivity were of similar magnitude. Thigh muscle mass was preserved (P=0.8). Serum sTfR concentration decreased significantly (P=0.001). Interestingly, higher the thigh muscle volume after weight loss, higher the decrease in circulating sTfR concentration. We also found that higher the increases in leg force at week 16, higher the decrease in circulating sTfR concentration in all individuals as a whole. No significant changes were observed in insulin sensitivity, sTfR concentration or thigh muscle mass in the C group. Conclusion: These findings suggest a long-term regulation of serum sTfR concentration by exercise-induced improvement of insulin ensitivity in obese individuals.