Person: Alcántara Alcántara, Juan Manuel
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Alcántara Alcántara
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Juan Manuel
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Ciencias de la Salud
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0000-0002-8842-374X
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812411
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Publication Open Access Reliability of resting metabolic rate measurements in young adults: impact of methods for data analysis(Elsevier, 2018) Sánchez Delgado, Guillermo; Alcántara Alcántara, Juan Manuel; Ortiz Álvarez, Lourdes; Xu, Huiwen; Martínez Téllez, Borja; Labayen Goñi, Idoia; Ruiz, Jonatan R.; Ciencias de la Salud; Osasun ZientziakBackground and aims: a high inter-day reliability is a key factor to analyze the magnitude of change in resting metabolic rate (RMR) after an intervention, and the impact of using different methods for data analysis is not known. The aims of this study were: i) to analyze the impact of methods for data analysis on RMR and respiratory exchange ratio (RER) estimation; ii) to analyze the impact of methods for data analysis on inter-day RMR and RER reliability; iii) to compare inter-day RMR and RER reliability across methods for data analysis in participants who achieved steady state (SS) vs. participants who did not achieve SS. Methods: Seventeen young healthy adults completed two 30-min indirect calorimetry (IC) measures on two consecutive mornings, using two metabolic carts each day. Two methods for data analysis were used: i) Selection of a predefined time interval (TI) every 5 min (1-5 min, 6-10 min, 11-15 min, 16-20 min, 21-25 min, 26-30 min); and TI representing the whole measurement period (0-30 min, 5-30 min, 5-25 min); and ii) Methods based on the selection of the most stable period (SSt methods) (3 min SSt, 4 min SSt, 5 min SSt, 10 min SSt). Additionally, participants were classified as those achieving SS (CV < 10% for VO2, VCO2 and VE, and CV < 5% for RER) and those who did not. Results: RMR and RER measurements were lower when following SSt methods than when following TI methods (all P < 0.01). Although no significant differences were found between different lengths of SSt, 5 min SSt presented the lowest RMR. There were no differences on the inter-day reliability across methods for data analysis (TI and SSt) (all P > 0.2), and there was no systematic bias when comparing RMR and RER day 1 and day 2 measurements (all P > 0.1). Inter-day reliability was similar in individuals who achieved the SS and individuals who did not achieve it. The results were consistent independently of the metabolic cart used. Conclusions: The 5 min SSt approach should be the method of choice for analyzing IC measures with metabolic carts. However, achieving SS should not be an inclusion criterion in an IC study with young healthy adults.Publication Open Access Associations between intra-assessment resting metabolic rate variability and health-related factors(MDPI, 2022) Alcántara Alcántara, Juan Manuel; Osuna Prieto, Francisco J.; Plaza Florido, Abel; Ciencias de la Salud; Osasun Zientziak; Institute on Innovation and Sustainable Development in Food Chain - ISFOODIn humans, the variation in resting metabolic rate (RMR) might be associated with health-related factors, as suggested by previous studies. This study explored whether the intra-assessment RMR variability (expressed as a coefficient of variation (CV; %)) is similar in men and women and if it is similarly associated with diverse health-related factors. The RMR of 107 young, and relatively healthy adults, was assessed using indirect calorimetry. Then, the CV for volumes of oxygen consumption (VO2) and carbon dioxide production (VCO2), respiratory exchange ratio (RER), and resting energy expenditure (REE) were computed as indicators of intra-assessment RMR variability. Body composition, cardiorespiratory fitness (peak VO2 uptake), circulating cardiometabolic risk factors, and heart rate and its variability (HR and HRV) were assessed. Men presented higher CVs for VO2, VCO2, and REE (all p <= 0.001) compared to women. Furthermore, in men, the intra-assessment RER variability was associated with vagal-related HRV parameters and with mean HR (standardized beta = -0.36, -0.38, and 0.41, respectively; all p < 0.04). In contrast, no associations were observed in women. In conclusion, men exhibited higher variability (CVs for VO2, VCO2, and REE) compared to women. The CV for RER could be a potential marker of cardiometabolic risk in young men.Publication Open Access Reproducibility of the energy metabolism response to an oral glucose tolerance test: influence of a postcalorimetric correction procedure(Springer, 2022) Alcántara Alcántara, Juan Manuel; Sánchez Delgado, Guillermo; Jurado Fasoli, Lucas; Galgani, Jose E.; Labayen Goñi, Idoia; Ruiz, Jonatan R.; Institute on Innovation and Sustainable Development in Food Chain - ISFOODPurpose Metabolic fexibility (MetF), which is a surrogate of metabolic health, can be assessed by the change in the respiratory exchange ratio (RER) in response to an oral glucose tolerance test (OGTT). We aimed to determine the day-to-day reproducibility of the energy expenditure (EE) and RER response to an OGTT, and whether a simulation-based postcalorimetric correction of metabolic cart readouts improves day-to-day reproducibility. Methods The EE was assessed (12 young adults, 6 women, 27±2 years old) using an Omnical metabolic cart (Maastricht Instruments, Maastricht, The Netherlands) after an overnight fast (12 h) and after a 75-g oral glucose dose on 2 separate days (48 h). On both days, we assessed EE in 7 periods (one 30-min baseline and six 15-min postprandial). The ICcE was performed immediately after each recording period, and capillary glucose concentration (using a digital glucometer) was determined. Results We observed a high day-to-day reproducibility for the assessed RER (coefcients of variation [CV]<4%) and EE (CVs<9%) in the 7 diferent periods. In contrast, the RER and EE areas under the curve showed a low day-to-day reproducibility (CV=22% and 56%, respectively). Contrary to our expectations, the postcalorimetric correction procedure did not infuence the day-to-day reproducibility of the energy metabolism response, possibly because the Omnical’s accuracy was~100%. Conclusion Our study demonstrates that the energy metabolism response to an OGTT is poorly reproducible (CVs>20%) even using a very accurate metabolic cart. Furthermore, the postcalorimetric correction procedure did not infuence the day-to-day reproducibility. Trial registration NCT04320433; March 25, 2020.