Person:
Veramendi Charola, Jon

Profile Picture

Email Address

person.page.identifierURI

https://academica-e.unavarra.es/handle/2454/50148

Birth Date

Research Projects

Organizational Units

Job Title

Last Name

Veramendi Charola

First Name

Jon

person.page.departamento

Agronomía, Biotecnología y Alimentación

person.page.instituteName

IMAB. Research Institute for Multidisciplinary Applied Biology

ORCID

0000-0002-3214-213X

person.page.upna

539

Name

Filters

2001 - 20082
Reset filters

Settings

Author: Veramendi Charola, Jon × Start date: 2001 × End date: 2008 ×

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    PublicationOpen Access
    Potato genetic resources in Spain
    (International Plant Genetic Resources Institute, 2001) Ritter, E.; Ruiz de Galarreta, José Ignacio; Carrasco, A.; Ruiz De Arcaute Rivero, Roberto; Veramendi Charola, Jon; Mingo Castel, Ángel; IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua
    Plant genetic resources activities in Spain are globally organized by the Instituto Nacional de Investigación Agraria (INIA) and in particular by one of its institutes, Centro de Recursos Fitogenéticos (CRF). Collections of beans, maize, cereals and many other crops are maintained, evaluated and characterized in the station at Alcala de Henares near Madrid. However, the situation is different for potato. Germplasm collections of potato are maintained in collaborating institutes or private companies. The largest collection with 604 accessions is held at NEIKER (former CIMA, Centro de Investigación y Mejora Agraria), which has been traditionally, as the Station for potato improvement (Estación de la Mejora de la Patata), the cradle of seed potatoes in Spain. Other remarkable collections are maintained at the Public University of Navarra (UPNA), the Instituto de Agrobiotecnología y Recursos Naturales (116 accessions) and the public enterprise APPACALE (213 accessions), which produces seed potatoes and also performs potato breeding in Spain.
  • Thumbnail Image
    PublicationOpen Access
    Human papillomavirus L1 protein expressed in tobacco chloroplasts self-assembles into virus-like particles that are highly immunogenic
    (Wiley, 2008) Fernández San Millán, Alicia; Martín Ortigosa, Susana; Hervás Stubbs, Sandra; Corral-Martínez, Patricia; Seguí-Simarro, José M.; Gaétan, Julien; Coursaget, Pierre; Veramendi Charola, Jon; IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua
    Cervical cancer is the second most prevalent cancer in women worldwide. It is linked to infection with human papillomavirus (HPV). As the virus cannot be propagated in culture, vaccines based on virus‐like particles have been developed and recently marketed. However, their high costs constitute an important drawback for widespread use in developing countries, where the incidence of cervical cancer is highest. In a search for alternative production systems, the major structural protein of the HPV‐16 capsid, L1, was expressed in tobacco chloroplasts. A very high yield of production was achieved in mature plants (~3 mg L1/g fresh weight; equivalent to 24% of total soluble protein). This is the highest expression level of HPV L1 protein reported in plants. A single mature plant synthesized ~240 mg of L1. The chloroplast‐derived L1 protein displayed conformation‐specific epitopes and assembled into virus‐like particles, visible by transmission electron microscopy. Furthermore, leaf protein extracts from L1 transgenic plants were highly immunogenic in mice after intraperitoneal injection, and neutralizing antibodies were detected. Taken together, these results predict a promising future for the development of a plant‐based vaccine against HPV.