Santano Rivero, Desiree
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Santano Rivero
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Desiree
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Ingeniería Eléctrica, Electrónica y de Comunicación
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Publication Open Access Direct functionalization of TiO2/PSS sensing layer for an LMR-based optical fiber reusable biosensor(IEEE, 2023) Santano Rivero, Desiree; Socorro Leránoz, Abián Bentor; Del Villar, Ignacio; Ingeniería Eléctrica, Electrónica y de Comunicación; Institute of Smart Cities - ISC; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa, PJUPNA2033Functionalization plays a crucial role in the development of biosensors. In this study, bioreceptors were directly immobilized onto the surface of a sensing layer after physical activation, avoiding the need for longer and more complex functionalization systems. This direct immobilization was applied to an optical sensing platform based on lossy mode resonances (LMRs) generated by a thin-film of titanium (IV) dioxide/poly(sodium 4-styrenesulfonate) (TiO 2 /PSS). To generate the LMR, a 200-micron bare optical fiber was coated with TiO 2 /PSS using the layer-by-layer self-assembly technique. The PSS of the sensing layer was then physically activated using either UV-ozone or plasma to immobilize anti-rabbit IgG bioreceptors. This enabled specific and label-free detection of rabbit IgG concentrations ranging from 0.002 to 2 mg/ml. The results presented in this work include real-time detection of rabbit IgG, a comparison between the two activation techniques (UV-ozone and plasma), and an analysis of the biosensor’s reusability over four consecutive cycles, which demonstrates the promising potential of the TiO 2 /PSS sensing layer for biosensing applications.Publication Open Access Regenerable LMR-based fiber optic immunosensor with a SnO2 metallic oxide thin film for label-free detection(Elsevier, 2025-02-02) Santano Rivero, Desiree; Zubiate Orzanco, Pablo; Socorro Leránoz, Abián Bentor; Del Villar, Ignacio; Ingeniería Eléctrica, Electrónica y de Comunicación; Ingeniaritza Elektrikoa, Elektronikoa eta Telekomunikazio Ingeniaritza; Institute of Smart Cities - ISC; Universidad Pública de Navarra / Nafarroako Unibertsitate PublikoaThis paper introduces the fabrication and characterization of a regenerable LMR-based, label-free optical fiber immunosensor. This innovative biosensor proposal was developed by functionalizing a SnO2 metallic oxide thin film deposited on a D-shaped optical fiber using a silanization protocol. The system successfully detected IgG - anti-IgG complexes in real-time in a range of concentrations from 0.5 to 10 ¿g/ml and achieved a limit of detection (LoD) of 0.12 μg/ml of anti-IgG. The biosensor was extensively tested to assess its capacity for regeneration, confirming that it can be reused repeatedly, reducing the overall cost and waste typically associated with disposable sensors. This regenerability has significant implications for a range of applications, providing a more sustainable and flexible approach to biosensing technology.Publication Open Access Trends in the design of wavelength-based optical fibre biosensors (2008–2018)(Elsevier, 2019) Socorro Leránoz, Abián Bentor; Santano Rivero, Desiree; Del Villar, Ignacio; Matías Maestro, Ignacio; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Institute of Smart Cities - ISC; Ingeniería Eléctrica, Electrónica y de Comunicación; Gobierno de Navarra / Nafarroako GobernuaDuring the last decades, both governments and companies have been committed to the continuous checking of biological parameters, which can prevent extra costs to administrations. A very efficient way to address this issue is by designing biosensors. This contribution reviews the advances made using optical fibre technology, which have lately agglutinated much of the scientific interest related to the development of biosensors. However, the wide number of publications describing the use of optical fibre for detecting biomarkers has probably blurred the main goal: obtaining portable, simple, easy-to-handle and cost-effective biosensors. With this purpose, this contribution presents some optical fibre structures which have been analysed in terms of several optical parameters of interest from a photonics point of view: sensitivity, quality factor, full width at half minimum, limit of detection and figure of merit. This has made it possible to classify the most advanced optical fibre sensing techniques and, hence, their suitability when developing biosensing applications.