Villaño Valencia, Débora

Profile Picture

Email Address

person.page.identifierURI

https://academica-e.unavarra.es/handle/2454/50168

Birth Date

Job Title

Last Name

Villaño Valencia

First Name

Débora

person.page.departamento

Agronomía, Biotecnología y Alimentación

person.page.instituteName

IS-FOOD. Research Institute on Innovation & Sustainable Development in Food Chain

ORCID

0000-0002-8162-8857

person.page.observainves

751211

person.page.upna

812286

Name

Filters

20231
Reset filters

Settings

Has files: true × Subject: Black garlic ×

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    PublicationOpen Access
    Effect of black garlic consumption on endothelial function and lipid profile: a before-and-after study in hypercholesterolemic and non-hypercholesterolemic subjects
    (MDPI, 2023) Villaño Valencia, Débora; Marhuenda, Javier; Arcusa, Raúl; Moreno-Rojas, José Manuel; Cerdá, Begoña; Pereira-Caro, Gema; Zafrilla, Pilar; Agronomía, Biotecnología y Alimentación; Agronomia, Bioteknologia eta Elikadura; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
    Background: Black garlic is obtained from raw garlic (Allium sativum L.), by a fermentation process, under humidity and heat treatment, showing a high concentration of organosulfur compounds, which have been related to benefits in the prevention or delay of cardiovascular diseases (CVDs). The objective of the research was to evaluate whether long-term consumption of black garlic improves endothelial function and lipid profile in subjects with hypercholesterolemia. Methods: Single center, controlled clinical trial with two branches: Hypercholesterolemia vs. Healthy condition. Sixty-two subjects of both sexes were distributed in two groups, the hypercholesterolemia group (n = 31) (total cholesterol (TC) range 200-300 mg/dL and low-density lipoprotein (LDL)-cholesterol range 135-175 mg/dL) and the healthy group (n = 31). The intervention consisted of the ingestion of 4 cloves of black garlic (12 g) daily for 12 weeks. Results: significant increases in Apolipoprotein (Apo)A1 occurred in both groups: Hypercholesterolemia (& UDelta; 11.8 mg/dL p < 0.001) vs Healthy (& UDelta; 11.1 mg/dL p < 0.001). Besides, significant reductions for endothelial adhesion molecules monocyte chemoattractant protein-1 (MCP-1) (& UDelta; -121.5 pg/mL p = 0.007 vs. & UDelta; -56.3 pg/mL p = 0.015), intracellular adhesion molecule-1 (ICAM-1) (& UDelta; -39.3 ng/mL p < 0.001 vs. & UDelta; 63.5 ng/mL p < 0.001), and vascular cyto-adhesion molecule-1 (VCAM-1) (& UDelta; -144.4 ng/mL p < 0.001 vs. & UDelta; -83.4 ng/mL p = 0.061) were observed, for hypercholesterolemic and healthy subjects, respectively. Conclusions: These data show that black garlic consumption could improve some parameters related to endothelial function and lipid profile, which may have a favorable impact on the risk of CVDs, although more long-term studies are necessary to confirm.